Body mass index and weight change are associated with adult lung function trajectories: The prospective ECRHS study

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  • Gabriela P. Peralta, Barcelona Institute for Global Health, Pompeu Fabra University, Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP)
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  • Alessandro Marcon, University of Verona
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  • Anne Elie Carsin, Barcelona Institute for Global Health, Pompeu Fabra University, Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP)
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  • Michael J. Abramson, Monash University
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  • Simone Accordini, University of Verona
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  • André F.S. Amaral, National Heart and Lung Institute
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  • Josep M. Antó, Barcelona Institute for Global Health, Pompeu Fabra University, Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP)
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  • Gayan Bowatte, University of Melbourne, Institute of Fundamental Studies Kandy
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  • Peter Burney, National Heart and Lung Institute
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  • Angelo Corsico, IRCCS Policlinico S. Matteo Foundation
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  • Pascal Demoly, Hopital Arnaud de Villeneuve, Institut National de la Recherche Agronomique
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  • Shyamali Dharmage, University of Melbourne
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  • Bertil Forsberg, Clinical Sciences, Umea universitet, Klinisk vetenskap.
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  • Elaine Fuertes, National Heart and Lung Institute
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  • Vanessa Garcia-Larsen, Johns Hopkins Bloomberg School of Public Health
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  • Thorarinn Gíslason, Landspitali University Hospital, University of Iceland
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  • José Antonio Gullón, Hospital San Agustin
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  • Joachim Heinrich, University of Melbourne, Ludwig Maximilian University of Munich, German Center for Lung Research (DZL)
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  • Mathias Holm, Gøteborg Transplantationscenter, Sahlgrenska Universitetssjukhuset
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  • Deborah L. Jarvis, National Heart and Lung Institute, Imperial College London
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  • Christer Janson, Uppsala Universitet
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  • Rain Jogi, Tartu University Hospital
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  • Ane Johannessen, University of Bergen, Department of Occupational Medicine, Haukeland University Hospital, NO-5021 Bergen, Norway. tor.aasen@helse-bergen.no.
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  • Bénédicte Leynaert, Universite Paris-Saclay
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  • Jesús Martínez Moratalla Rovira, University of Castilla-La Mancha
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  • Dennis Nowak, Ludwig Maximilian University of Munich, German Center for Lung Research (DZL)
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  • Nicole Probst-Hensch, Swiss Tropical and Public Health Institute (Swiss TPH), University of Basel
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  • Chantal Raherison, Universite Bordeaux
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  • José Luis Sánchez-Ramos, University of Huevla
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  • Torben Sigsgaard
  • Valérie Siroux, CNRS
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  • Giulia Squillacioti, Università degli Studi di Torino
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  • Isabel Urrutia, Galdakao Hospital
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  • Joost Weyler, University of Antwerp
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  • Jan Paul Zock, Barcelona Institute for Global Health, Pompeu Fabra University, Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP)
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  • Judith Garcia-Aymerich, Barcelona Institute for Global Health, Pompeu Fabra University, Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP)

Background: Previous studies have reported an association between weight increase and excess lung function decline in young adults followed for short periods. We aimed to estimate lung function trajectories during adulthood from 20-year weight change profiles using data from the population-based European Community Respiratory Health Survey (ECRHS). Methods: We included 3673 participants recruited at age 20-44 years with repeated measurements of weight and lung function (forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1)) in three study waves (1991-93, 1999-2003, 2010-14) until they were 39-67 years of age. We classified subjects into weight change profiles according to baseline body mass index (BMI) categories and weight change over 20 years. We estimated trajectories of lung function over time as a function of weight change profiles using population-averaged generalised estimating equations. Results: In individuals with normal BMI, overweight and obesity at baseline, moderate (0.25-1 kg/year) and high weight gain (>1 kg/year) during follow-up were associated with accelerated FVC and FEV1 declines. Compared with participants with baseline normal BMI and stable weight (±0.25 kg/year), obese individuals with high weight gain during follow-up had-1011 mL (95% CI-1.259 to-763) lower estimated FVC at 65 years despite similar estimated FVC levels at 25 years. Obese individuals at baseline who lost weight (<-0.25 kg/year) exhibited an attenuation of FVC and FEV1 declines. We found no association between weight change profiles and FEV1/FVC decline. Conclusion: Moderate and high weight gain over 20 years was associated with accelerated lung function decline, while weight loss was related to its attenuation. Control of weight gain is important for maintaining good lung function in adult life.

OriginalsprogEngelsk
TidsskriftThorax
Vol/bind75
Nummer4
Sider (fra-til)313-320
Antal sider8
ISSN0040-6376
DOI
StatusUdgivet - 2020

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