Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition

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  • Sofia Christakoudi, MRC Centre for Transplantation, King's College London, Great Maze Pond, London SE1 9RT, United Kingdom., Storbritannien
  • Artemisia Kakourou, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece, Grækenland
  • Georgios Markozannes, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece, Grækenland
  • Ioanna Tzoulaki, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece, Grækenland
  • Elisabete Weiderpass, 1Nutritional Methodology and Biostatistics Group, International Agency for Research on Cancer (IARC), World Health Organization, 150 cours Albert Thomas, 69372 Lyon CEDEX 08, France., Frankrig
  • Paul Brennan, 1Nutritional Methodology and Biostatistics Group, International Agency for Research on Cancer (IARC), World Health Organization, 150 cours Albert Thomas, 69372 Lyon CEDEX 08, France., Frankrig
  • Marc Gunter, 1Nutritional Methodology and Biostatistics Group, International Agency for Research on Cancer (IARC), World Health Organization, 150 cours Albert Thomas, 69372 Lyon CEDEX 08, France.
  • ,
  • Christina C Dahm
  • Kim Overvad
  • Anja Olsen, Kræftens Bekæmpelse, Danmark
  • Anne Tjønneland, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark., Danmark
  • Marie-Christine Boutron-Ruault, Institut Gustave Roussy, Villejuif, France., Frankrig
  • Anne-Laure Madika, Université Lille, INSERM, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE-Risk Factors and Molecular Determinants of Aging-related Diseases, Lille, France., Frankrig
  • Gianluca Severi, Institut Gustave Roussy, Villejuif, France., Frankrig
  • Verena Katzke, German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, 69120 Heidelberg, Germany. V.Katzke@Dkfz-Heidelberg.de., Tyskland
  • Tilman Kühn, German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, 69120 Heidelberg, Germany. V.Katzke@Dkfz-Heidelberg.de., Tyskland
  • Manuela M Bergmann, German Institute of Human Nutrition, Potsdam-Rehbrücke (DIfE), Department of Epidemiology, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany., Tyskland
  • Heiner Boeing, German Institute of Human Nutrition, Potsdam-Rehbrücke (DIfE), Department of Epidemiology, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany., Tyskland
  • Anna Karakatsani, 2nd Pulmonary Medicine Department, School of Medicine, National and Kapodistrian University of Athens, "ATTIKON" University Hospital, Haidari, Greece., Grækenland
  • Georgia Martimianaki, Hellenic Health Foundation, Athens, Greece., Grækenland
  • Paschalis Thriskos, Hellenic Health Foundation, Athens, Greece., Grækenland
  • Giovanna Masala, Cancer Risk Factors and Life-Style Epidemiology Unit. Institute for Cancer Research, Prevention and Clinical Network - ISPRO, 50141, Florence, Italy., Italien
  • Sabina Sieri, Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy., Italien
  • Salvatore Panico, Dipartimento di Medicina Clinica e Chirurgia, Università degli Studi di Federico II University, Naples, Italy., Italien
  • Rosario Tumino, Cancer Registry and Histopathology Department, Civic-M.P.Arezzo Hospital, ASP, 97100 Ragusa, Italy. rtumino@tin.it., Italien
  • Fulvio Ricceri, Unit of Epidemiology, Regional Health Service ASL TO3, 10095 Grugliasco (Turin), Italy., Italien
  • Antonio Agudo, Unit of Nutrition and Cancer. Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain., Spanien
  • Daniel Redondo-Sánchez, CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain., Spanien
  • Sandra M Colorado-Yohar, Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia., Colombia
  • Olatz Mokoroa, Public Health Division of Gipuzkoa, Basque Government, Spain; Health Research Institute, Biodonostia, San Sebastián, Spain., Spanien
  • Olle Melander, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden., Sverige
  • Tanja Stocks, Department of Cardiothoracic Surgery, Skane University Hospital, Lund, Sweden; Clinical Sciences, Lund University, Lund, Sweden., Sverige
  • Christel Häggström, Department of Surgical Sciences, Thoracic Surgery, Uppsala University, Uppsala, Sweden., Sverige
  • Sophia Harlid, k Department of Radiation Sciences , Umeå University , Umeå , Sweden., Sverige
  • Bas Bueno-de-Mesquita, Former Academic Icon / visiting professor, Dept. of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Pantai Valley, 50603, Kuala Lumpur, Malaysia., Malaysia
  • Carla H van Gils, Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands., Holland
  • Roel C H Vermeulen, 1] School of Public Health, Imperial College, London, UK [2] Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands., Holland
  • Kay-Tee Khaw, University of Cambridge, School of Clinical Medicine, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0SP, United Kingdom., Storbritannien
  • Nicholas J Wareham, MRC Epidemiology Unit, Institute of Metabolic Science, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom., Storbritannien
  • Tammy Y N Tong, Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford, United Kingdom., Storbritannien
  • Heinz Freisling, 1Nutritional Methodology and Biostatistics Group, International Agency for Research on Cancer (IARC), World Health Organization, 150 cours Albert Thomas, 69372 Lyon CEDEX 08, France., Frankrig
  • Mattias Johansson, 1Nutritional Methodology and Biostatistics Group, International Agency for Research on Cancer (IARC), World Health Organization, 150 cours Albert Thomas, 69372 Lyon CEDEX 08, France., Frankrig
  • Hannah Lennon, 1Nutritional Methodology and Biostatistics Group, International Agency for Research on Cancer (IARC), World Health Organization, 150 cours Albert Thomas, 69372 Lyon CEDEX 08, France., Frankrig
  • Dagfinn Aune, Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, 0372 Oslo, Norway. d.aune@imperial.ac.uk., Storbritannien
  • Elio Riboli, Department of Epidemiology and Biostatistics, , The School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, London, W2 1PG London, United Kingdom., Storbritannien
  • Dimitrios Trichopoulos, 1] Hellenic Health Foundation, Athens, Greece [2] Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece., Grækenland
  • Antonia Trichopoulou, Hellenic Health Foundation, Athens, Greece., Grækenland
  • Konstantinos K Tsilidis, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece, Grækenland

Several studies have reported associations of hypertension with cancer, but not all results were conclusive. We examined the association of systolic (SBP) and diastolic (DBP) blood pressure with the development of incident cancer at all anatomical sites in the European Prospective Investigation into Cancer and Nutrition (EPIC). Hazard ratios (HRs) (95% confidence intervals) were estimated using multivariable Cox proportional hazards models, stratified by EPIC-participating center and age at recruitment, and adjusted for sex, education, smoking, body mass index, physical activity, diabetes and dietary (in women also reproductive) factors. The study included 307,318 men and women, with an average follow-up of 13.7 (standard deviation 4.4) years and 39,298 incident cancers. We confirmed the expected positive association with renal cell carcinoma: HR = 1.12 (1.08–1.17) per 10 mm Hg higher SBP and HR = 1.23 (1.14–1.32) for DBP. We additionally found positive associations for esophageal squamous cell carcinoma (SCC): HR = 1.16 (1.07–1.26) (SBP), HR = 1.31 (1.13–1.51) (DBP), weaker for head and neck cancers: HR = 1.08 (1.04–1.12) (SBP), HR = 1.09 (1.01–1.17) (DBP) and, similarly, for skin SCC, colon cancer, postmenopausal breast cancer and uterine adenocarcinoma (AC), but not for esophageal AC, lung SCC, lung AC or uterine endometroid cancer. We observed weak inverse associations of SBP with cervical SCC: HR = 0.91 (0.82–1.00) and lymphomas: HR = 0.97 (0.93–1.00). There were no consistent associations with cancers in other locations. Our results are largely compatible with published studies and support weak associations of blood pressure with cancers in specific locations and morphologies.

OriginalsprogEngelsk
TidsskriftInternational Journal of Cancer
Vol/bind146
Nummer10
Sider (fra-til)2680-2693
Antal sider14
ISSN0020-7136
DOI
StatusUdgivet - 15 maj 2020

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