β-Blockers Improve Presinusoidal Portal Hypertension

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β-Blockers Improve Presinusoidal Portal Hypertension. / Sørensen, Michael; Larsen, Lars P; Villadsen, Gerda E; Aagaard, Niels K; Grønbæk, Henning; Keiding, Susanne; Vilstrup, Hendrik.

I: Digestive Diseases and Sciences, Bind 63, Nr. 11, 11.2018, s. 3153-3157.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{12738a04668d45048ba6fa9d94aff0f8,
title = "β-Blockers Improve Presinusoidal Portal Hypertension",
abstract = "BACKGROUND: Presinusoidal portal hypertension is a clinically important cause of gastric and gastroesophageal varices. Whereas β-blockers have an established prophylactic role against bleeding from esophageal and gastric varices in portal hypertension due to cirrhosis, the effect on presinusoidal portal hypertension is unknown.AIMS: To evaluate the hemodynamic effect of β-blockers in non-cirrhotic patients with presinusoidal portal hypertension.METHODS: We measured the blood pressure gradient from spleen pulp to free hepatic vein in 12 patients with presinusoidal portal hypertension by combined hepatic vein catheterization and spleen pulp puncture while on and off β-blocker treatment (random sequence).RESULTS: The β-blockers reduced the gradient from a mean off-treatment value of 32 mm Hg to a on-treatment value of 26 mm Hg (P < 0.05) with a reduction of at least 20% in five patients (42%).CONCLUSIONS: β-blocker treatment caused a clinically significant reduction in the pressure gradient from spleen pulp to the free hepatic vein. This finding supports the recommendation for prophylactic β-blockage in patients with presinusoidal portal hypertension.",
author = "Michael S{\o}rensen and Larsen, {Lars P} and Villadsen, {Gerda E} and Aagaard, {Niels K} and Henning Gr{\o}nb{\ae}k and Susanne Keiding and Hendrik Vilstrup",
year = "2018",
month = nov,
doi = "10.1007/s10620-018-5186-1",
language = "English",
volume = "63",
pages = "3153--3157",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Springer New York LLC",
number = "11",

}

RIS

TY - JOUR

T1 - β-Blockers Improve Presinusoidal Portal Hypertension

AU - Sørensen, Michael

AU - Larsen, Lars P

AU - Villadsen, Gerda E

AU - Aagaard, Niels K

AU - Grønbæk, Henning

AU - Keiding, Susanne

AU - Vilstrup, Hendrik

PY - 2018/11

Y1 - 2018/11

N2 - BACKGROUND: Presinusoidal portal hypertension is a clinically important cause of gastric and gastroesophageal varices. Whereas β-blockers have an established prophylactic role against bleeding from esophageal and gastric varices in portal hypertension due to cirrhosis, the effect on presinusoidal portal hypertension is unknown.AIMS: To evaluate the hemodynamic effect of β-blockers in non-cirrhotic patients with presinusoidal portal hypertension.METHODS: We measured the blood pressure gradient from spleen pulp to free hepatic vein in 12 patients with presinusoidal portal hypertension by combined hepatic vein catheterization and spleen pulp puncture while on and off β-blocker treatment (random sequence).RESULTS: The β-blockers reduced the gradient from a mean off-treatment value of 32 mm Hg to a on-treatment value of 26 mm Hg (P < 0.05) with a reduction of at least 20% in five patients (42%).CONCLUSIONS: β-blocker treatment caused a clinically significant reduction in the pressure gradient from spleen pulp to the free hepatic vein. This finding supports the recommendation for prophylactic β-blockage in patients with presinusoidal portal hypertension.

AB - BACKGROUND: Presinusoidal portal hypertension is a clinically important cause of gastric and gastroesophageal varices. Whereas β-blockers have an established prophylactic role against bleeding from esophageal and gastric varices in portal hypertension due to cirrhosis, the effect on presinusoidal portal hypertension is unknown.AIMS: To evaluate the hemodynamic effect of β-blockers in non-cirrhotic patients with presinusoidal portal hypertension.METHODS: We measured the blood pressure gradient from spleen pulp to free hepatic vein in 12 patients with presinusoidal portal hypertension by combined hepatic vein catheterization and spleen pulp puncture while on and off β-blocker treatment (random sequence).RESULTS: The β-blockers reduced the gradient from a mean off-treatment value of 32 mm Hg to a on-treatment value of 26 mm Hg (P < 0.05) with a reduction of at least 20% in five patients (42%).CONCLUSIONS: β-blocker treatment caused a clinically significant reduction in the pressure gradient from spleen pulp to the free hepatic vein. This finding supports the recommendation for prophylactic β-blockage in patients with presinusoidal portal hypertension.

U2 - 10.1007/s10620-018-5186-1

DO - 10.1007/s10620-018-5186-1

M3 - Journal article

C2 - 30003386

VL - 63

SP - 3153

EP - 3157

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

IS - 11

ER -