Bioresponsive nanoparticles for the intracellular delivery of RNAi therapeutics

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The process of RNA interference (RNAi) by which cellular gene expression is controlled through the specific action of small interfering RNA (siRNA) is set to revolutionalise disease treatment. A greater understanding of the RNA pathway has resulted in an expanding repertoire of potential RNAi-based drugs whose action is dependent on intracellular target interaction. This work describes the use of polymeric nanoparticles used to overcome intracellular barriers and facilitate interaction of RNAi triggers with the RNAi machinery. Focus will be given to bioresponsive nanoparticles based on copolypeptides and hyperbranched polymers for controlling the intracellular spatial and temporal efects of synthetic microRNA and siRNA.
OriginalsprogEngelsk
TitelNanotechnology for the Delivery of Therapeutic Nucleic Acids
Antal sider23
ForlagPan Stanford Publishing
Udgivelsesår31 mar. 2013
Sider129-151
KapitelB
ISBN (trykt)9789814411042
DOI
StatusUdgivet - 31 mar. 2013

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