Biological and mechanical characterization of commercial and experimental periodontal surgical dressings

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  • Luciana Domingues Conceição, Universidade Federal de Pelotas, Brasilien
  • Carlos Enrique Cuevas-Suárez, Universidad Autonoma del Estado de Hidalgo, Mexico
  • Evandro Piva, Universidade Federal de Pelotas, Brasilien
  • Rafael Guerra Lund, Universidade Federal de Pelotas, Brasilien
  • Fabio Renato Manzolli Leite

The objective of this study was to evaluate the biocompatibility and mechanical properties of two commercially available and one experimental periodontal dressing materials. The cytotoxicity of Periobond ® , Barricaid ® and one experimental periodontal dressing based on Exothane ® 8 monomer was tested on 3T3/NIH mouse fibroblast. Genotoxicity was assessed by micronuclei formation, and cell alterations were analyzed using light microscopy. Both biological assays were performed using the eluate obtained from specimens after 24, 72, or 168 hours of incubation. Mechanical characterization was assessed through the ultimate tensile strength and the water sorption and solubility tests. The significance level of α = 0.05 was used for all statistical analyses. All the materials promoted a cell viability lower than 60% in all evaluated times. In general, the cell viability was significantly reduced after 72 and 168h of specimens' incubation. Considering the factor material, there were not statistical differences in the cell viability (p = 0.156). The genotoxicity was not statistically significant among the groups in the different periods of time (p > 0.05). Differences in the ultimate tensile strength values were not statistically significant different among the groups (p = 0.125). Periobond ® showed the higher water sorption values (p < 0.001). Regarding solubility, there were no statistical differences between the groups (p = 0.098). All the periodontal dressing materials evaluated in this study exerted a cytotoxic effect against mouse fibroblasts, and their toxicity became more evident over time. Among the materials evaluated, the experimental light-cure type has shown overall similar properties to the commercial references.

OriginalsprogEngelsk
Artikelnummere045
TidsskriftBrazilian Oral Research
Vol/bind35
Antal sider9
ISSN1806-8324
DOI
StatusUdgivet - 2021

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