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Biogenesis and Function of Ago-Associated RNAs

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Biogenesis and Function of Ago-Associated RNAs. / Daugaard, Iben; Hansen, Thomas Birkballe.

I: Trends in Genetics, Bind 33, Nr. 3, 03.2017, s. 208-219.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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Daugaard, Iben ; Hansen, Thomas Birkballe. / Biogenesis and Function of Ago-Associated RNAs. I: Trends in Genetics. 2017 ; Bind 33, Nr. 3. s. 208-219.

Bibtex

@article{15de1e712e7d4fedbed9a0826becc96c,
title = "Biogenesis and Function of Ago-Associated RNAs",
abstract = "Numerous sophisticated high-throughput sequencing technologies have been developed over the past decade, and these have enabled the discovery of a diverse catalog of small non-coding (nc)RNA molecules that function as regulatory entities by associating with Argonaute (Ago) proteins. MicroRNAs (miRNAs) are currently the best-described class of post-transcriptional regulators that follow a specific biogenesis pathway characterized by Drosha/DGCR8 and Dicer processing. However, more exotic miRNA-like species that bypass particular steps of the canonical miRNA biogenesis pathway continue to emerge, with one of the most recent additions being the agotrons, which escape both Drosha/DGCR8- and Dicer-processing. We review here the current knowledge and most recent discoveries relating to alternative functions and biogenesis strategies for Ago-associated RNAs in mammals.",
keywords = "Journal Article, Review",
author = "Iben Daugaard and Hansen, {Thomas Birkballe}",
note = "Copyright {\circledC} 2017 Elsevier Ltd. All rights reserved.",
year = "2017",
month = "3",
doi = "10.1016/j.tig.2017.01.003",
language = "English",
volume = "33",
pages = "208--219",
journal = "Trends in Genetics",
issn = "0168-9525",
publisher = "Elsevier Ltd. * Trends Journals",
number = "3",

}

RIS

TY - JOUR

T1 - Biogenesis and Function of Ago-Associated RNAs

AU - Daugaard, Iben

AU - Hansen, Thomas Birkballe

N1 - Copyright © 2017 Elsevier Ltd. All rights reserved.

PY - 2017/3

Y1 - 2017/3

N2 - Numerous sophisticated high-throughput sequencing technologies have been developed over the past decade, and these have enabled the discovery of a diverse catalog of small non-coding (nc)RNA molecules that function as regulatory entities by associating with Argonaute (Ago) proteins. MicroRNAs (miRNAs) are currently the best-described class of post-transcriptional regulators that follow a specific biogenesis pathway characterized by Drosha/DGCR8 and Dicer processing. However, more exotic miRNA-like species that bypass particular steps of the canonical miRNA biogenesis pathway continue to emerge, with one of the most recent additions being the agotrons, which escape both Drosha/DGCR8- and Dicer-processing. We review here the current knowledge and most recent discoveries relating to alternative functions and biogenesis strategies for Ago-associated RNAs in mammals.

AB - Numerous sophisticated high-throughput sequencing technologies have been developed over the past decade, and these have enabled the discovery of a diverse catalog of small non-coding (nc)RNA molecules that function as regulatory entities by associating with Argonaute (Ago) proteins. MicroRNAs (miRNAs) are currently the best-described class of post-transcriptional regulators that follow a specific biogenesis pathway characterized by Drosha/DGCR8 and Dicer processing. However, more exotic miRNA-like species that bypass particular steps of the canonical miRNA biogenesis pathway continue to emerge, with one of the most recent additions being the agotrons, which escape both Drosha/DGCR8- and Dicer-processing. We review here the current knowledge and most recent discoveries relating to alternative functions and biogenesis strategies for Ago-associated RNAs in mammals.

KW - Journal Article

KW - Review

U2 - 10.1016/j.tig.2017.01.003

DO - 10.1016/j.tig.2017.01.003

M3 - Journal article

C2 - 28174021

VL - 33

SP - 208

EP - 219

JO - Trends in Genetics

JF - Trends in Genetics

SN - 0168-9525

IS - 3

ER -