Aarhus University Seal / Aarhus Universitets segl

Biogenesis and Function of Ago-Associated RNAs

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

Numerous sophisticated high-throughput sequencing technologies have been developed over the past decade, and these have enabled the discovery of a diverse catalog of small non-coding (nc)RNA molecules that function as regulatory entities by associating with Argonaute (Ago) proteins. MicroRNAs (miRNAs) are currently the best-described class of post-transcriptional regulators that follow a specific biogenesis pathway characterized by Drosha/DGCR8 and Dicer processing. However, more exotic miRNA-like species that bypass particular steps of the canonical miRNA biogenesis pathway continue to emerge, with one of the most recent additions being the agotrons, which escape both Drosha/DGCR8- and Dicer-processing. We review here the current knowledge and most recent discoveries relating to alternative functions and biogenesis strategies for Ago-associated RNAs in mammals.

OriginalsprogEngelsk
TidsskriftTrends in Genetics
Vol/bind33
Nummer3
Sider (fra-til)208-219
Antal sider12
ISSN0168-9525
DOI
StatusUdgivet - mar. 2017

Se relationer på Aarhus Universitet Citationsformater

ID: 110460110