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Forlagets udgivne version
Numerous sophisticated high-throughput sequencing technologies have been developed over the past decade, and these have enabled the discovery of a diverse catalog of small non-coding (nc)RNA molecules that function as regulatory entities by associating with Argonaute (Ago) proteins. MicroRNAs (miRNAs) are currently the best-described class of post-transcriptional regulators that follow a specific biogenesis pathway characterized by Drosha/DGCR8 and Dicer processing. However, more exotic miRNA-like species that bypass particular steps of the canonical miRNA biogenesis pathway continue to emerge, with one of the most recent additions being the agotrons, which escape both Drosha/DGCR8- and Dicer-processing. We review here the current knowledge and most recent discoveries relating to alternative functions and biogenesis strategies for Ago-associated RNAs in mammals.
Originalsprog | Engelsk |
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Tidsskrift | Trends in Genetics |
Vol/bind | 33 |
Nummer | 3 |
Sider (fra-til) | 208-219 |
Antal sider | 12 |
ISSN | 0168-9525 |
DOI | |
Status | Udgivet - mar. 2017 |
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