Biochemistry and Function of the RNA Exosomes

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Biochemistry and Function of the RNA Exosomes. / Lubas, Michal Szymon; Chlebowski , Aleksander; Dziembowski , Andrzej; Jensen, Torben Heick.

The Enzymes: Eukaryotic RNases and their Partners in RNA Degradation and Biogenesis, Part A. red. / Guillaume F Chanfreau; Fuyuhiko Tamanoi. Bind 31 Elsevier, 2012. s. 1-30 (The Enzymes).

Publikation: Bidrag til bog/antologi/rapport/proceedingBidrag til bog/antologiForskningpeer review

Harvard

Lubas, MS, Chlebowski , A, Dziembowski , A & Jensen, TH 2012, Biochemistry and Function of the RNA Exosomes. i GF Chanfreau & F Tamanoi (red), The Enzymes: Eukaryotic RNases and their Partners in RNA Degradation and Biogenesis, Part A. bind 31, Elsevier, The Enzymes, s. 1-30. https://doi.org/10.1016/B978-0-12-404740-2.00001-X

APA

Lubas, M. S., Chlebowski , A., Dziembowski , A., & Jensen, T. H. (2012). Biochemistry and Function of the RNA Exosomes. I G. F. Chanfreau, & F. Tamanoi (red.), The Enzymes: Eukaryotic RNases and their Partners in RNA Degradation and Biogenesis, Part A (Bind 31, s. 1-30). Elsevier. The Enzymes https://doi.org/10.1016/B978-0-12-404740-2.00001-X

CBE

Lubas MS, Chlebowski A, Dziembowski A, Jensen TH. 2012. Biochemistry and Function of the RNA Exosomes. Chanfreau GF, Tamanoi F, red. I The Enzymes: Eukaryotic RNases and their Partners in RNA Degradation and Biogenesis, Part A. Elsevier. s. 1-30. (The Enzymes). https://doi.org/10.1016/B978-0-12-404740-2.00001-X

MLA

Lubas, Michal Szymon o.a.. "Biochemistry and Function of the RNA Exosomes". og Chanfreau, Guillaume F Tamanoi, Fuyuhiko (red.). The Enzymes: Eukaryotic RNases and their Partners in RNA Degradation and Biogenesis, Part A. Kapitel 1, Elsevier. (The Enzymes). 2012, 1-30. https://doi.org/10.1016/B978-0-12-404740-2.00001-X

Vancouver

Lubas MS, Chlebowski A, Dziembowski A, Jensen TH. Biochemistry and Function of the RNA Exosomes. I Chanfreau GF, Tamanoi F, red., The Enzymes: Eukaryotic RNases and their Partners in RNA Degradation and Biogenesis, Part A. Bind 31. Elsevier. 2012. s. 1-30. (The Enzymes). https://doi.org/10.1016/B978-0-12-404740-2.00001-X

Author

Lubas, Michal Szymon ; Chlebowski , Aleksander ; Dziembowski , Andrzej ; Jensen, Torben Heick. / Biochemistry and Function of the RNA Exosomes. The Enzymes: Eukaryotic RNases and their Partners in RNA Degradation and Biogenesis, Part A. red. / Guillaume F Chanfreau ; Fuyuhiko Tamanoi. Bind 31 Elsevier, 2012. s. 1-30 (The Enzymes).

Bibtex

@inbook{526395fb65664ef68f61c612261a7b38,
title = "Biochemistry and Function of the RNA Exosomes",
abstract = "Discovery of the evolutionary conserved RNA exosome was a milestone in RNA biology. First identified as an activity essential for the processing of ribosomal RNA, the exosome has since proved to be central for RNA processing and degradation in both the nucleus and the cytoplasm of eukaryotic cells. This multisubunit protein complex consists of a catalytically inert 9-subunit core endowed with associated ribonucleolytic activities and further assisted by compartment-specific cofactors required for its activation and substrate targeting. Although many features of exosome biology are known, fundamental aspects are still under investigation. In this chapter, we review current biochemical and functional knowledge of eukaryotic exosomes. After introducing some of their nuclear and cytoplasmic functions, we discuss the structural organization and evolutionary aspects of exosome complexes. Finally, we describe catalytic properties of the complex and its regulation by cofactor",
author = "Lubas, {Michal Szymon} and Aleksander Chlebowski and Andrzej Dziembowski and Jensen, {Torben Heick}",
year = "2012",
doi = "10.1016/B978-0-12-404740-2.00001-X",
language = "English",
isbn = "978-0-12-404740-2 ",
volume = "31",
series = "The Enzymes",
pages = "1--30",
editor = "Chanfreau, {Guillaume F} and Fuyuhiko Tamanoi",
booktitle = "The Enzymes",
publisher = "Elsevier",

}

RIS

TY - CHAP

T1 - Biochemistry and Function of the RNA Exosomes

AU - Lubas, Michal Szymon

AU - Chlebowski , Aleksander

AU - Dziembowski , Andrzej

AU - Jensen, Torben Heick

PY - 2012

Y1 - 2012

N2 - Discovery of the evolutionary conserved RNA exosome was a milestone in RNA biology. First identified as an activity essential for the processing of ribosomal RNA, the exosome has since proved to be central for RNA processing and degradation in both the nucleus and the cytoplasm of eukaryotic cells. This multisubunit protein complex consists of a catalytically inert 9-subunit core endowed with associated ribonucleolytic activities and further assisted by compartment-specific cofactors required for its activation and substrate targeting. Although many features of exosome biology are known, fundamental aspects are still under investigation. In this chapter, we review current biochemical and functional knowledge of eukaryotic exosomes. After introducing some of their nuclear and cytoplasmic functions, we discuss the structural organization and evolutionary aspects of exosome complexes. Finally, we describe catalytic properties of the complex and its regulation by cofactor

AB - Discovery of the evolutionary conserved RNA exosome was a milestone in RNA biology. First identified as an activity essential for the processing of ribosomal RNA, the exosome has since proved to be central for RNA processing and degradation in both the nucleus and the cytoplasm of eukaryotic cells. This multisubunit protein complex consists of a catalytically inert 9-subunit core endowed with associated ribonucleolytic activities and further assisted by compartment-specific cofactors required for its activation and substrate targeting. Although many features of exosome biology are known, fundamental aspects are still under investigation. In this chapter, we review current biochemical and functional knowledge of eukaryotic exosomes. After introducing some of their nuclear and cytoplasmic functions, we discuss the structural organization and evolutionary aspects of exosome complexes. Finally, we describe catalytic properties of the complex and its regulation by cofactor

U2 - 10.1016/B978-0-12-404740-2.00001-X

DO - 10.1016/B978-0-12-404740-2.00001-X

M3 - Book chapter

C2 - 27166438

SN - 978-0-12-404740-2

VL - 31

T3 - The Enzymes

SP - 1

EP - 30

BT - The Enzymes

A2 - Chanfreau, Guillaume F

A2 - Tamanoi, Fuyuhiko

PB - Elsevier

ER -