Binding of chemical carcinogens to macromolecules in cultured human colon.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisLetterForskningpeer review

DOI

  • Herman Autrup
  • C.C. Harris, USA
  • G.D. Stoner, USA
  • M.L. Jesudason, USA
  • B.F. Trump, USA
  • Afdeling for Miljø- og Arbejdsmedicin
Metabolic activation of different chemical classes of carcinogens was studied in cultured human colon epithelia. Human colon epithelia were maintained in explant culture up to 4 days. Binding of benzo(a)pyrene, dimethylnitrosamine, and 1,2-
dimethylhydrazine was found in both cell DNA and protein. 1,2-Dimethylhydrazine methylated DNA at both N·7 and 0-6 positions of guanin.
OriginalsprogEngelsk
TidsskriftNational Cancer Institute. Journal (Print)
Vol/bind59
Nummer2
Sider (fra-til)351-354
Antal sider4
ISSN0027-8874
DOI
StatusUdgivet - 1977

Se relationer på Aarhus Universitet Citationsformater

ID: 1211218