Bestrophin is important for the rhythmic but not the tonic contraction in rat mesenteric small arteries

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Bestrophin is important for the rhythmic but not the tonic contraction in rat mesenteric small arteries. / Broegger, Torbjoern; Jacobsen, Jens Christian Brings; Dam, Vibeke Secher; Boedtkjer, Donna M Briggs; Kold-Petersen, Henrik; Pedersen, Finn Skou; Aalkjaer, Christian; Matchkov, Vladimir V.

I: Advances in Cardiovascular Research, Bind 91, Nr. 4, 2011, s. 685-93.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{3117e855804340dfb83cd8c9968483a1,
title = "Bestrophin is important for the rhythmic but not the tonic contraction in rat mesenteric small arteries",
abstract = "We have previously characterized a cGMP-dependent Ca(2+)-activated Cl(-) current in vascular smooth muscle cells (SMCs) and have shown its dependence on bestrophin-3 expression. We hypothesize that this current is important for synchronization of SMCs in the vascular wall. In the present study, we aimed to test this hypothesis by transfecting rat mesenteric small arteries in vivo with siRNA specifically targeting bestrophin-3.",
keywords = "Animals, Arginine Vasopressin, Calcium, Chloride Channels, Male, Mesenteric Arteries, Norepinephrine, RNA, Messenger, RNA, Small Interfering, Rats, Rats, Wistar, Transfection, Vasoconstriction",
author = "Torbjoern Broegger and Jacobsen, {Jens Christian Brings} and Dam, {Vibeke Secher} and Boedtkjer, {Donna M Briggs} and Henrik Kold-Petersen and Pedersen, {Finn Skou} and Christian Aalkjaer and Matchkov, {Vladimir V}",
year = "2011",
doi = "10.1093/cvr/cvr111",
language = "English",
volume = "91",
pages = "685--93",
journal = "Advances in Cardiovascular Research",
issn = "2159-1717",
publisher = "Nova Science Publishers",
number = "4",

}

RIS

TY - JOUR

T1 - Bestrophin is important for the rhythmic but not the tonic contraction in rat mesenteric small arteries

AU - Broegger, Torbjoern

AU - Jacobsen, Jens Christian Brings

AU - Dam, Vibeke Secher

AU - Boedtkjer, Donna M Briggs

AU - Kold-Petersen, Henrik

AU - Pedersen, Finn Skou

AU - Aalkjaer, Christian

AU - Matchkov, Vladimir V

PY - 2011

Y1 - 2011

N2 - We have previously characterized a cGMP-dependent Ca(2+)-activated Cl(-) current in vascular smooth muscle cells (SMCs) and have shown its dependence on bestrophin-3 expression. We hypothesize that this current is important for synchronization of SMCs in the vascular wall. In the present study, we aimed to test this hypothesis by transfecting rat mesenteric small arteries in vivo with siRNA specifically targeting bestrophin-3.

AB - We have previously characterized a cGMP-dependent Ca(2+)-activated Cl(-) current in vascular smooth muscle cells (SMCs) and have shown its dependence on bestrophin-3 expression. We hypothesize that this current is important for synchronization of SMCs in the vascular wall. In the present study, we aimed to test this hypothesis by transfecting rat mesenteric small arteries in vivo with siRNA specifically targeting bestrophin-3.

KW - Animals

KW - Arginine Vasopressin

KW - Calcium

KW - Chloride Channels

KW - Male

KW - Mesenteric Arteries

KW - Norepinephrine

KW - RNA, Messenger

KW - RNA, Small Interfering

KW - Rats

KW - Rats, Wistar

KW - Transfection

KW - Vasoconstriction

U2 - 10.1093/cvr/cvr111

DO - 10.1093/cvr/cvr111

M3 - Journal article

C2 - 21498420

VL - 91

SP - 685

EP - 693

JO - Advances in Cardiovascular Research

JF - Advances in Cardiovascular Research

SN - 2159-1717

IS - 4

ER -