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Best practice standards for circular RNA research
Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
DOI
- https://doi.org/10.1038/s41592-022-01487-2
Forlagets udgivne version
- Anne Færch Nielsen
- Albrecht Bindereif, Justus Liebig University Giessen ,
- Irene Bozzoni, University of Rome La Sapienza ,
- Mor Hanan, Hebrew University of Jerusalem ,
- Thomas Birkballe Hansen ,
- Manuel Irimia, ICFO-Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology, Universitat Pompeu Fabra, ICREA ,
- Sebastian Kadener, Brandeis University ,
- Lasse Sommer Kristensen
- Ivano Legnini, Helmholtz-Gemeinschaft Deutscher Forschungszentren ,
- Mariangela Morlando, University of Perugia ,
- Morten Tobias Jarlstad Olesen
- R Jeroen Pasterkamp, Utrecht University ,
- Stephan Preibisch, Helmholtz-Gemeinschaft Deutscher Forschungszentren ,
- Nikolaus Rajewsky, Helmholtz-Gemeinschaft Deutscher Forschungszentren ,
- Christin Sünkel, Helmholtz-Gemeinschaft Deutscher Forschungszentren ,
- Jørgen Kjems
Circular RNAs (circRNAs) are formed in all domains of life and via different mechanisms. There has been an explosion in the number of circRNA papers in recent years; however, as a relatively young field, circRNA biology has an urgent need for common experimental standards for isolating, analyzing, expressing and depleting circRNAs. Here we propose a set of guidelines for circRNA studies based on the authors’ experience. This Perspective will specifically address the major class of circRNAs in Eukarya that are generated by a spliceosome-catalyzed back-splicing event. We hope that the implementation of best practice principles for circRNA research will help move the field forward and allow a better functional understanding of this fascinating group of RNAs.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Nature Methods |
| Vol/bind | 19 |
| Nummer | 10 |
| Sider (fra-til) | 1208-1220 |
| Antal sider | 13 |
| ISSN | 1548-7091 |
| DOI | |
| Status | Udgivet - okt. 2022 |
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