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Benzoxazinoids in human diet: an anti-cancer agent?

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DOI

Benzoxazinoids (BXs) are phytochemicals present in selected cereal crops and medicinal plants. Effects of BXs in plants as plant defense and allelopathic agents has been widely studied [1, 2], while the knowledge into effects in mammals are limited. Potential therapeutic effects of BXs in humans [3], and presence of BXs in prostate cancer tissue in prostate cancer patients fed with a diet of rye, which is rich in BXs, [4], motivated us towards exploring the effects of BXs in prostate cancer cells. The effects of these compounds were studied in experiment exposing prostate cancer cell lines LNCap, DU145, PC3, and C4, and primary prostate cancer cells to selected BXs. Agluconic forms of BXs, which were reported to be the most active form of the compounds, were tested. BXs, DIBOA (2, 4-dihydroxy-1,4-benzoxazin-3-one) and DIMBOA (2, 4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one) caused a decrease in cell viability across all the cell lines tested. The IC50 of the compounds ranged from 40 to 200 μM across different cell lines. The results are encouraging and further experiments will be carried out using RNA sequencing. The ultimate goal is to understand the mechanism behind the potential anti-cancer effect of BXs and to elucidate whether they can be therapeutic agents.
OriginalsprogEngelsk
TidsskriftPlanta Medica
Vol/bind85
Nummer18
Sider (fra-til)1516-1517
Antal sider2
ISSN0032-0943
DOI
StatusUdgivet - 4 sep. 2019
Begivenhed67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research - Innsbruck, Østrig
Varighed: 1 sep. 20195 sep. 2019
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0039-3399629

Konference

Konference67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research
LandØstrig
ByInnsbruck
Periode01/09/201905/09/2019
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