Benzo(a)pyrene diol epoxides as intermediates in nucleic acid binding in vivo and in vitro

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • I.B. Weinstein, Danmark
  • A.M. Jeffrey, Danmark
  • K.W. Jennette, Danmark
  • S.H. Blobstein, Danmark
  • R.G. Harvey, Danmark
  • C. Harris, Danmark
  • Herman Autrup
  • H. Kasai, Danmark
  • K. Nakanishi, Danmark
  • Afdeling for Miljø- og Arbejdsmedicin
Evidence has been obtained that a specific isomer of a diol epoxide derivative of benzo(a)pyrene, (+/-)-7 beta,8alpha-dihydroxy-9alpha, 10alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene, is an intermediate in the binding of benzo(a)pyrene to RNA in cultured bovine bronchial mucosa. An adduct is formed between position 10 of this derivative and the 2-amino group of guanine.
OriginalsprogEngelsk
TidsskriftScience
Vol/bind193
Nummer4253
Sider (fra-til)1067-1069
Antal sider3
ISSN0036-8075
StatusUdgivet - 13 aug. 1976

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