Being overweight in childhood, puberty, or early adulthood: Changing asthma risk in the next generation?

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Being overweight in childhood, puberty, or early adulthood : Changing asthma risk in the next generation? / Johannessen, Ane; Lønnebotn, Marianne; Calciano, Lucia; Benediktsdóttir, Bryndis; Bertelsen, Randi Jacobsen; Bråbäck, Lennart; Dharmage, Shyamali; Franklin, Karl A; Gislason, Thorarinn; Holm, Mathias; Janson, Christer; Jarvis, Deborah; Jõgi, Rain; Kim, Jeong-Lim; Kirkeleit, Jorunn; Lodge, Caroline; Malinovschi, Andrei; Martinez-Moratalla, Jesus; Nilsen, Roy Miodini; Pereira-Vega, Antonio; Real, Francisco Gómez; Schlünssen, Vivi; Accordini, Simone; Svanes, Cecilie.

I: The Journal of allergy and clinical immunology, Bind 145, Nr. 3, 2020, s. 791-799.e4.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Johannessen, A, Lønnebotn, M, Calciano, L, Benediktsdóttir, B, Bertelsen, RJ, Bråbäck, L, Dharmage, S, Franklin, KA, Gislason, T, Holm, M, Janson, C, Jarvis, D, Jõgi, R, Kim, J-L, Kirkeleit, J, Lodge, C, Malinovschi, A, Martinez-Moratalla, J, Nilsen, RM, Pereira-Vega, A, Real, FG, Schlünssen, V, Accordini, S & Svanes, C 2020, 'Being overweight in childhood, puberty, or early adulthood: Changing asthma risk in the next generation?', The Journal of allergy and clinical immunology, bind 145, nr. 3, s. 791-799.e4. https://doi.org/10.1016/j.jaci.2019.08.030

APA

Johannessen, A., Lønnebotn, M., Calciano, L., Benediktsdóttir, B., Bertelsen, R. J., Bråbäck, L., Dharmage, S., Franklin, K. A., Gislason, T., Holm, M., Janson, C., Jarvis, D., Jõgi, R., Kim, J-L., Kirkeleit, J., Lodge, C., Malinovschi, A., Martinez-Moratalla, J., Nilsen, R. M., ... Svanes, C. (2020). Being overweight in childhood, puberty, or early adulthood: Changing asthma risk in the next generation? The Journal of allergy and clinical immunology, 145(3), 791-799.e4. https://doi.org/10.1016/j.jaci.2019.08.030

CBE

Johannessen A, Lønnebotn M, Calciano L, Benediktsdóttir B, Bertelsen RJ, Bråbäck L, Dharmage S, Franklin KA, Gislason T, Holm M, Janson C, Jarvis D, Jõgi R, Kim J-L, Kirkeleit J, Lodge C, Malinovschi A, Martinez-Moratalla J, Nilsen RM, Pereira-Vega A, Real FG, Schlünssen V, Accordini S, Svanes C. 2020. Being overweight in childhood, puberty, or early adulthood: Changing asthma risk in the next generation?. The Journal of allergy and clinical immunology. 145(3):791-799.e4. https://doi.org/10.1016/j.jaci.2019.08.030

MLA

Johannessen, Ane o.a.. "Being overweight in childhood, puberty, or early adulthood: Changing asthma risk in the next generation?". The Journal of allergy and clinical immunology. 2020, 145(3). 791-799.e4. https://doi.org/10.1016/j.jaci.2019.08.030

Vancouver

Johannessen A, Lønnebotn M, Calciano L, Benediktsdóttir B, Bertelsen RJ, Bråbäck L o.a. Being overweight in childhood, puberty, or early adulthood: Changing asthma risk in the next generation? The Journal of allergy and clinical immunology. 2020;145(3):791-799.e4. https://doi.org/10.1016/j.jaci.2019.08.030

Author

Johannessen, Ane ; Lønnebotn, Marianne ; Calciano, Lucia ; Benediktsdóttir, Bryndis ; Bertelsen, Randi Jacobsen ; Bråbäck, Lennart ; Dharmage, Shyamali ; Franklin, Karl A ; Gislason, Thorarinn ; Holm, Mathias ; Janson, Christer ; Jarvis, Deborah ; Jõgi, Rain ; Kim, Jeong-Lim ; Kirkeleit, Jorunn ; Lodge, Caroline ; Malinovschi, Andrei ; Martinez-Moratalla, Jesus ; Nilsen, Roy Miodini ; Pereira-Vega, Antonio ; Real, Francisco Gómez ; Schlünssen, Vivi ; Accordini, Simone ; Svanes, Cecilie. / Being overweight in childhood, puberty, or early adulthood : Changing asthma risk in the next generation?. I: The Journal of allergy and clinical immunology. 2020 ; Bind 145, Nr. 3. s. 791-799.e4.

Bibtex

@article{ca848ec42a92416c9bc7e972d155c2b2,
title = "Being overweight in childhood, puberty, or early adulthood: Changing asthma risk in the next generation?",
abstract = "BACKGROUND: Overweight status and asthma have increased during the last decades. Being overweight is a known risk factor for asthma, but it is not known whether it might also increase asthma risk in the next generation.OBJECTIVE: We aimed to examine whether parents being overweight in childhood, adolescence, or adulthood is associated with asthma in their offspring.METHODS: We included 6347 adult offspring (age, 18-52 years) investigated in the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) multigeneration study of 2044 fathers and 2549 mothers (age, 37-66 years) investigated in the European Community Respiratory Health Survey (ECRHS) study. Associations of parental overweight status at age 8 years, puberty, and age 30 years with offspring's childhood overweight status (potential mediator) and offspring's asthma with or without nasal allergies (outcomes) was analyzed by using 2-level logistic regression and 2-level multinomial logistic regression, respectively. Counterfactual-based mediation analysis was performed to establish whether observed associations were direct or indirect effects mediated through the offspring's own overweight status.RESULTS: We found statistically significant associations between both fathers' and mothers' childhood overweight status and offspring's childhood overweight status (odds ratio, 2.23 [95% CI, 1.45-3.42] and 2.45 [95% CI, 1.86-3.22], respectively). We also found a statistically significant effect of fathers' onset of being overweight in puberty on offspring's asthma without nasal allergies (relative risk ratio, 2.31 [95% CI, 1.23-4.33]). This effect was direct and not mediated through the offspring's own overweight status. No effect on offspring's asthma with nasal allergies was found.CONCLUSION: Our findings suggest that metabolic factors long before conception can increase asthma risk and that male puberty is a time window of particular importance for offspring's health.",
keywords = "Ageing Lungs in European Cohorts (ALEC) Study, epidemiology, multilevel mediation model, offspring, parental risk factors",
author = "Ane Johannessen and Marianne L{\o}nnebotn and Lucia Calciano and Bryndis Benediktsd{\'o}ttir and Bertelsen, {Randi Jacobsen} and Lennart Br{\aa}b{\"a}ck and Shyamali Dharmage and Franklin, {Karl A} and Thorarinn Gislason and Mathias Holm and Christer Janson and Deborah Jarvis and Rain J{\~o}gi and Jeong-Lim Kim and Jorunn Kirkeleit and Caroline Lodge and Andrei Malinovschi and Jesus Martinez-Moratalla and Nilsen, {Roy Miodini} and Antonio Pereira-Vega and Real, {Francisco G{\'o}mez} and Vivi Schl{\"u}nssen and Simone Accordini and Cecilie Svanes",
note = "Copyright {\textcopyright} 2019 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2020",
doi = "10.1016/j.jaci.2019.08.030",
language = "English",
volume = "145",
pages = "791--799.e4",
journal = "Journal of Allergy and Clinical Immunology",
issn = "0091-6749",
publisher = "Mosby, Inc",
number = "3",

}

RIS

TY - JOUR

T1 - Being overweight in childhood, puberty, or early adulthood

T2 - Changing asthma risk in the next generation?

AU - Johannessen, Ane

AU - Lønnebotn, Marianne

AU - Calciano, Lucia

AU - Benediktsdóttir, Bryndis

AU - Bertelsen, Randi Jacobsen

AU - Bråbäck, Lennart

AU - Dharmage, Shyamali

AU - Franklin, Karl A

AU - Gislason, Thorarinn

AU - Holm, Mathias

AU - Janson, Christer

AU - Jarvis, Deborah

AU - Jõgi, Rain

AU - Kim, Jeong-Lim

AU - Kirkeleit, Jorunn

AU - Lodge, Caroline

AU - Malinovschi, Andrei

AU - Martinez-Moratalla, Jesus

AU - Nilsen, Roy Miodini

AU - Pereira-Vega, Antonio

AU - Real, Francisco Gómez

AU - Schlünssen, Vivi

AU - Accordini, Simone

AU - Svanes, Cecilie

N1 - Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2020

Y1 - 2020

N2 - BACKGROUND: Overweight status and asthma have increased during the last decades. Being overweight is a known risk factor for asthma, but it is not known whether it might also increase asthma risk in the next generation.OBJECTIVE: We aimed to examine whether parents being overweight in childhood, adolescence, or adulthood is associated with asthma in their offspring.METHODS: We included 6347 adult offspring (age, 18-52 years) investigated in the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) multigeneration study of 2044 fathers and 2549 mothers (age, 37-66 years) investigated in the European Community Respiratory Health Survey (ECRHS) study. Associations of parental overweight status at age 8 years, puberty, and age 30 years with offspring's childhood overweight status (potential mediator) and offspring's asthma with or without nasal allergies (outcomes) was analyzed by using 2-level logistic regression and 2-level multinomial logistic regression, respectively. Counterfactual-based mediation analysis was performed to establish whether observed associations were direct or indirect effects mediated through the offspring's own overweight status.RESULTS: We found statistically significant associations between both fathers' and mothers' childhood overweight status and offspring's childhood overweight status (odds ratio, 2.23 [95% CI, 1.45-3.42] and 2.45 [95% CI, 1.86-3.22], respectively). We also found a statistically significant effect of fathers' onset of being overweight in puberty on offspring's asthma without nasal allergies (relative risk ratio, 2.31 [95% CI, 1.23-4.33]). This effect was direct and not mediated through the offspring's own overweight status. No effect on offspring's asthma with nasal allergies was found.CONCLUSION: Our findings suggest that metabolic factors long before conception can increase asthma risk and that male puberty is a time window of particular importance for offspring's health.

AB - BACKGROUND: Overweight status and asthma have increased during the last decades. Being overweight is a known risk factor for asthma, but it is not known whether it might also increase asthma risk in the next generation.OBJECTIVE: We aimed to examine whether parents being overweight in childhood, adolescence, or adulthood is associated with asthma in their offspring.METHODS: We included 6347 adult offspring (age, 18-52 years) investigated in the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) multigeneration study of 2044 fathers and 2549 mothers (age, 37-66 years) investigated in the European Community Respiratory Health Survey (ECRHS) study. Associations of parental overweight status at age 8 years, puberty, and age 30 years with offspring's childhood overweight status (potential mediator) and offspring's asthma with or without nasal allergies (outcomes) was analyzed by using 2-level logistic regression and 2-level multinomial logistic regression, respectively. Counterfactual-based mediation analysis was performed to establish whether observed associations were direct or indirect effects mediated through the offspring's own overweight status.RESULTS: We found statistically significant associations between both fathers' and mothers' childhood overweight status and offspring's childhood overweight status (odds ratio, 2.23 [95% CI, 1.45-3.42] and 2.45 [95% CI, 1.86-3.22], respectively). We also found a statistically significant effect of fathers' onset of being overweight in puberty on offspring's asthma without nasal allergies (relative risk ratio, 2.31 [95% CI, 1.23-4.33]). This effect was direct and not mediated through the offspring's own overweight status. No effect on offspring's asthma with nasal allergies was found.CONCLUSION: Our findings suggest that metabolic factors long before conception can increase asthma risk and that male puberty is a time window of particular importance for offspring's health.

KW - Ageing Lungs in European Cohorts (ALEC) Study

KW - epidemiology

KW - multilevel mediation model

KW - offspring

KW - parental risk factors

U2 - 10.1016/j.jaci.2019.08.030

DO - 10.1016/j.jaci.2019.08.030

M3 - Journal article

C2 - 31505189

VL - 145

SP - 791-799.e4

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

IS - 3

ER -