Being overweight in childhood, puberty, or early adulthood: Changing asthma risk in the next generation?

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  • Ane Johannessen, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway. Electronic address: Marianne.Lonnebotn@uib.no., Norge
  • Marianne Lønnebotn, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway. Electronic address: Marianne.Lonnebotn@uib.no., Norge
  • Lucia Calciano, Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy., Italien
  • Bryndis Benediktsdóttir, Department of Respiratory Medicine and Sleep, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland ; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland., Island
  • Randi Jacobsen Bertelsen, Department of Clinical Science, University of Bergen, Bergen, Norway; Department of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway., Norge
  • Lennart Bråbäck, Department of Public Health and Clinical Medicine/Occupational & Environmental Medicine, Umeå University, Umeå, Sweden., Sverige
  • Shyamali Dharmage, Allergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne, Australia., Australien
  • Karl A Franklin, Department of Surgical and perioperative Sciences/Surgery, Umeå University, Umeå, Sweden., Sverige
  • Thorarinn Gislason, Department of Respiratory Medicine and Sleep, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland ; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland., Island
  • Mathias Holm, Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden; Section of Occupational and Environmental Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Sverige
  • Christer Janson, Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden., Sverige
  • Deborah Jarvis, Faculty of Medicine, National Heart and Lung Institute, Imperial College, London, United Kingdom., Storbritannien
  • Rain Jõgi, Lung Clinic, Tartu University Hospital, Tartu, Estonia., Estland
  • Jeong-Lim Kim, University of Gothenburg, Sverige
  • Jorunn Kirkeleit, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway Norwegian Institute of Public Health, Oslo, Norway., Norge
  • Caroline Lodge, Department of Population Health, University of Melbourne, Melbourne, Australia., Australien
  • Andrei Malinovschi, Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden; Section of Clinical Chemistry, Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Sverige
  • Jesus Martinez-Moratalla, Servicio de Neurología del Complejo Hospitalario Universitario de Albacete (CHUA), Servicio de Salud de Castilla-La Mancha (SESCAM), Albacete, Spain., Spanien
  • Roy Miodini Nilsen, Department of Nursing, Bergen University College, Bergen, Norway., Norge
  • Antonio Pereira-Vega, Pneumology Section, Hospital Juan Ramón Jiménez, Huelva, Spain., Spanien
  • Francisco Gómez Real, Department of Clinical Science, University of Bergen and Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway., Norge
  • Vivi Schlünssen
  • Simone Accordini, Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy., Italien
  • Cecilie Svanes, Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway; Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway., Norge

BACKGROUND: Overweight status and asthma have increased during the last decades. Being overweight is a known risk factor for asthma, but it is not known whether it might also increase asthma risk in the next generation.

OBJECTIVE: We aimed to examine whether parents being overweight in childhood, adolescence, or adulthood is associated with asthma in their offspring.

METHODS: We included 6347 adult offspring (age, 18-52 years) investigated in the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) multigeneration study of 2044 fathers and 2549 mothers (age, 37-66 years) investigated in the European Community Respiratory Health Survey (ECRHS) study. Associations of parental overweight status at age 8 years, puberty, and age 30 years with offspring's childhood overweight status (potential mediator) and offspring's asthma with or without nasal allergies (outcomes) was analyzed by using 2-level logistic regression and 2-level multinomial logistic regression, respectively. Counterfactual-based mediation analysis was performed to establish whether observed associations were direct or indirect effects mediated through the offspring's own overweight status.

RESULTS: We found statistically significant associations between both fathers' and mothers' childhood overweight status and offspring's childhood overweight status (odds ratio, 2.23 [95% CI, 1.45-3.42] and 2.45 [95% CI, 1.86-3.22], respectively). We also found a statistically significant effect of fathers' onset of being overweight in puberty on offspring's asthma without nasal allergies (relative risk ratio, 2.31 [95% CI, 1.23-4.33]). This effect was direct and not mediated through the offspring's own overweight status. No effect on offspring's asthma with nasal allergies was found.

CONCLUSION: Our findings suggest that metabolic factors long before conception can increase asthma risk and that male puberty is a time window of particular importance for offspring's health.

OriginalsprogEngelsk
TidsskriftThe Journal of allergy and clinical immunology
Vol/bind145
Nummer3
Sider (fra-til)791-799.e4
Antal sider13
ISSN0091-6749
DOI
StatusUdgivet - 2020

Bibliografisk note

Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

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