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Behavioural relevance of spontaneous, transient brain network interactions in fMRI

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How spontaneously fluctuating functional magnetic resonance imaging (fMRI) signals in different brain regions relate to behaviour has been an open question for decades. Correlations in these signals, known as functional connectivity, can be averaged over several minutes of data to provide a stable representation of the functional network architecture for an individual. However, associations between these stable features and behavioural traits have been shown to be dominated by individual differences in anatomy. Here, using kernel learning tools, we propose methods to assess and compare the relation between time-varying functional connectivity, time-averaged functional connectivity, structural brain data, and non-imaging subject behavioural traits. We applied these methods to Human Connectome Project resting-state fMRI data to show that time-varying fMRI functional connectivity, detected at time-scales of a few seconds, has associations with some behavioural traits that are not dominated by anatomy. Despite time-averaged functional connectivity accounting for the largest proportion of variability in the fMRI signal between individuals, we found that some aspects of intelligence could only be explained by time-varying functional connectivity. The finding that time-varying fMRI functional connectivity has a unique relationship to population behavioural variability suggests that it might reflect transient neuronal communication fluctuating around a stable neural architecture.

OriginalsprogEngelsk
Artikelnummer117713
TidsskriftNeuroImage
Vol/bind229
ISSN1053-8119
DOI
StatusUdgivet - apr. 2021

Bibliografisk note

Funding Information:
DV is supported by a Novo Nordisk Emerging Investigator Award (NNF19OC-0054895) and by the European Research Council (ERC-StG-2019-850404). MWW's research is supported by the NIHR Oxford Health Biomedical Research Centre, by the Wellcome Trust ( 106183/Z/14/Z ), and the MRC UK MEG Partnership Grant ( MR/K005464/1 ). The Wellcome Centre for Integrative Neuroimaging is supported by core funding from the Wellcome Trust ( 203139/Z/16/Z ). AL is supported by the Horizon 2020 Programme CANDY (Grant No. 847818 ).

Publisher Copyright:
© 2021

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

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