Baseline and lifetime alcohol consumption and risk of skin cancer in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC)

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DOI

  • Yahya Mahamat-Saleh, Universite Paris-Saclay
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  • Marie Al-Rahmoun, Universite Paris-Saclay
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  • Gianluca Severi, Universite Paris-Saclay
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  • Reza Ghiasvand, University of Oslo
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  • Marit B Veierod, University of Oslo
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  • Saverio Caini, Institute for the Study and Prevention of Cancer
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  • Domenico Palli, Institute for the Study and Prevention of Cancer
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  • Edoardo Botteri, University of Oslo
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  • Carlotta Sacerdote, Piedmont Reference Centre for Epidemiology and Cancer Prevention (CPO Piemonte), Turin
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  • Fulvio Ricceri, Epidemiology Unit
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  • Marko Lukic, University Hospital of North Norway
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  • Maria J Sánchez, Escuela Andaluza de Salud Publica
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  • Valeria Pala, Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian, 1, 20133 Milano, Italy.
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  • Rosario Tumino, Hyblean Association for Epidemiological Research (AIRE-ONLUS)
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  • Paolo Chiodini, Dipartimento di Salute Mentale e Fisica e Medicina Preventiva
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  • Pilar Amiano, CIBER - Center for Biomedical Research Network
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  • Sandra Colorado-Yohar, CIBER - Center for Biomedical Research Network
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  • María-Dolores Chirlaque, CIBER - Center for Biomedical Research Network
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  • Eva Ardanaz, CIBER - Center for Biomedical Research Network
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  • Catalina Bonet, Catalan Institute of Oncology - ICO
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  • Verena Katzke, German Cancer Research Center
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  • Rudolf Kaaks, German Cancer Research Center
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  • Matthias B Schulze, German Institute of Human Nutrition Potsdam-Rehbruecke
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  • Kim Overvad
  • Christina C Dahm
  • Christian S Antoniussen
  • Anne Tjønneland, Kræftens Bekæmpelse
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  • Cecilie Kyrø, National Institute for Public Health and the Environment (RIVM)
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  • Bas Bueno-de-Mesquita, National Institute for Public Health and the Environment (RIVM)
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  • Jonas Manjer, Lund University
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  • Malin Jansson, Lund University, Malmö, Sweden; Umeå University, Umeå, Sweden.
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  • Anders Esberg, Lund University, Malmö, Sweden; Umeå University, Umeå, Sweden.
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  • Nagisa Mori, International Agency for Research on Cancer
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  • Pietro Ferrari, International Agency for Research on Cancer
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  • Elisabete Weiderpass, International Agency for Research on Cancer
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  • Marie-Christine Boutron-Ruault, Universite Paris-Saclay
  • ,
  • Marina Kvaskoff, Universite Paris-Saclay

Experimental evidence suggests that alcohol induces cutaneous carcinogenesis, yet epidemiological studies on the link between alcohol intake and skin cancer have been inconsistent. The European Prospective Investigation into Cancer and Nutrition (EPIC) is a prospective cohort initiated in 1992 in 10 European countries. Alcohol intake at baseline and average lifetime alcohol intake were assessed using validated country-specific dietary and lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated in Cox models. A total of 14 037 skin cancer cases (melanoma: n = 2457; basal-cell carcinoma (BCC): n = 8711; squamous-cell carcinoma (SCC): n = 1928; unknown: n = 941) were identified among 450 112 participants (average follow-up: 15 years). Baseline alcohol intake was positively associated with SCC (>15 vs 0.1-4.9 g/day: HR = 1.44, 95% CI = 1.17-1.77; Ptrend = .001), BCC (HR = 1.12, 95% CI = 1.01-1.23; Ptrend = .04), and melanoma risks in men (HR = 1.17, 95% CI = 0.95-1.44; Ptrend = .17), while associations were more modest in women (SCC: HR = 1.09, 95% CI = 0.90-1.30; Ptrend = .13; BCC: HR = 1.08, 95% CI = 1.00-1.17, Ptrend = .03; melanoma: HR = 0.93, 95% CI = 0.80-1.08, Ptrend = .13). Associations were similar for lifetime alcohol intake, with an attenuated linear trend. Lifetime liquor/spirit intake was positively associated with melanoma (fourth vs first quartile: HR = 1.47, 95% CI = 1.08-1.99; Ptrend = .0009) and BCC risks in men (HR = 1.17, 95% CI = 1.04-1.31; Ptrend = .14). Baseline and lifetime intakes of wine were associated with BCC risk (HR = 1.25 in men; HR = 1.11-1.12; in women). No statistically significant associations were found between beverage types and SCC risk. Intake of beer was not associated with skin cancer risk. Our study suggests positive relationships between alcohol intake and skin cancer risk, which may have important implications for the primary prevention of skin cancer.

OriginalsprogEngelsk
TidsskriftInternational Journal of Cancer
Vol/bind152
Nummer3
Sider (fra-til)348-362
Antal sider15
ISSN0020-7136
DOI
StatusUdgivet - feb. 2023

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