Bacillus Calmette-Guérin vaccination, thymic size, and thymic output in healthy newborns

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Bacillus Calmette-Guérin vaccination, thymic size, and thymic output in healthy newborns. / Birk, Nina Marie; Nissen, Thomas Nørrelykke; Zingmark, Vera; Kjærgaard, Jesper; Thøstesen, Lisbeth Marianne; Kofoed, Poul-Erik; Stensballe, Lone Graff; Andersen, Andreas; Nielsen, Susanne Dam; Benn, Christine Stabell; Pryds, Ole; Jeppesen, Dorthe Lisbeth.

I: Pediatric Research, Bind 81, Nr. 6, 06.2017, s. 873-880.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Birk, NM, Nissen, TN, Zingmark, V, Kjærgaard, J, Thøstesen, LM, Kofoed, P-E, Stensballe, LG, Andersen, A, Nielsen, SD, Benn, CS, Pryds, O & Jeppesen, DL 2017, 'Bacillus Calmette-Guérin vaccination, thymic size, and thymic output in healthy newborns', Pediatric Research, bind 81, nr. 6, s. 873-880. https://doi.org/10.1038/pr.2017.27

APA

Birk, N. M., Nissen, T. N., Zingmark, V., Kjærgaard, J., Thøstesen, L. M., Kofoed, P-E., ... Jeppesen, D. L. (2017). Bacillus Calmette-Guérin vaccination, thymic size, and thymic output in healthy newborns. Pediatric Research, 81(6), 873-880. https://doi.org/10.1038/pr.2017.27

CBE

Birk NM, Nissen TN, Zingmark V, Kjærgaard J, Thøstesen LM, Kofoed P-E, Stensballe LG, Andersen A, Nielsen SD, Benn CS, Pryds O, Jeppesen DL. 2017. Bacillus Calmette-Guérin vaccination, thymic size, and thymic output in healthy newborns. Pediatric Research. 81(6):873-880. https://doi.org/10.1038/pr.2017.27

MLA

Vancouver

Birk NM, Nissen TN, Zingmark V, Kjærgaard J, Thøstesen LM, Kofoed P-E o.a. Bacillus Calmette-Guérin vaccination, thymic size, and thymic output in healthy newborns. Pediatric Research. 2017 jun;81(6):873-880. https://doi.org/10.1038/pr.2017.27

Author

Birk, Nina Marie ; Nissen, Thomas Nørrelykke ; Zingmark, Vera ; Kjærgaard, Jesper ; Thøstesen, Lisbeth Marianne ; Kofoed, Poul-Erik ; Stensballe, Lone Graff ; Andersen, Andreas ; Nielsen, Susanne Dam ; Benn, Christine Stabell ; Pryds, Ole ; Jeppesen, Dorthe Lisbeth. / Bacillus Calmette-Guérin vaccination, thymic size, and thymic output in healthy newborns. I: Pediatric Research. 2017 ; Bind 81, Nr. 6. s. 873-880.

Bibtex

@article{d644cce0c6a1408fbc6c6ce9fb572570,
title = "Bacillus Calmette-Gu{\'e}rin vaccination, thymic size, and thymic output in healthy newborns",
abstract = "BACKGROUND: The Bacillus Calmette-Gu{\'e}rin vaccine (BCG) has been associated with beneficial nonspecific effects on infant health. We aimed to examine the effect of BCG at birth on thymic size and the associations between thymic output, circulating lymphocytes, risk of infection, and thymic size.METHODS: In infants randomized to BCG or no BCG, thymic index (TI), and thymic/weight index (TWI) were measured by ultrasound at birth and at the age of 3 mo. T cell subpopulations including CD4+ T cells, CD8+ T cells, and recent thymic emigrants (RTEs) were assessed by flow cytometry. Infections up to age 3 mo were parent-reported.RESULTS: BCG vaccination did not affect thymic size at age 3 mo, measured as TI. At birth, the number of lymphocytes, CD4+ T cells, CD8+ T cells, and RTEs were positively associated with TI and TWI. Furthermore, a reduced risk of infections up to age 3 mo was associated with a large thymic size at birth.CONCLUSION: We found no effect of BCG vaccination on thymic size. The positive association between thymic output, lymphocytes, reduced risk of infections, and TI/TWI suggests that assessment of TI/TWI by ultrasound may be a predictor of the immunological capacity in the newborn.",
keywords = "B-Lymphocyte Subsets, BCG Vaccine/administration & dosage, Female, Flow Cytometry, Humans, Infant, Newborn, Male, T-Lymphocyte Subsets, Thymus Gland/anatomy & histology",
author = "Birk, {Nina Marie} and Nissen, {Thomas N{\o}rrelykke} and Vera Zingmark and Jesper Kj{\ae}rgaard and Th{\o}stesen, {Lisbeth Marianne} and Poul-Erik Kofoed and Stensballe, {Lone Graff} and Andreas Andersen and Nielsen, {Susanne Dam} and Benn, {Christine Stabell} and Ole Pryds and Jeppesen, {Dorthe Lisbeth}",
year = "2017",
month = "6",
doi = "10.1038/pr.2017.27",
language = "English",
volume = "81",
pages = "873--880",
journal = "Pediatric Research",
issn = "0031-3998",
publisher = "Nature Publishing Group",
number = "6",

}

RIS

TY - JOUR

T1 - Bacillus Calmette-Guérin vaccination, thymic size, and thymic output in healthy newborns

AU - Birk, Nina Marie

AU - Nissen, Thomas Nørrelykke

AU - Zingmark, Vera

AU - Kjærgaard, Jesper

AU - Thøstesen, Lisbeth Marianne

AU - Kofoed, Poul-Erik

AU - Stensballe, Lone Graff

AU - Andersen, Andreas

AU - Nielsen, Susanne Dam

AU - Benn, Christine Stabell

AU - Pryds, Ole

AU - Jeppesen, Dorthe Lisbeth

PY - 2017/6

Y1 - 2017/6

N2 - BACKGROUND: The Bacillus Calmette-Guérin vaccine (BCG) has been associated with beneficial nonspecific effects on infant health. We aimed to examine the effect of BCG at birth on thymic size and the associations between thymic output, circulating lymphocytes, risk of infection, and thymic size.METHODS: In infants randomized to BCG or no BCG, thymic index (TI), and thymic/weight index (TWI) were measured by ultrasound at birth and at the age of 3 mo. T cell subpopulations including CD4+ T cells, CD8+ T cells, and recent thymic emigrants (RTEs) were assessed by flow cytometry. Infections up to age 3 mo were parent-reported.RESULTS: BCG vaccination did not affect thymic size at age 3 mo, measured as TI. At birth, the number of lymphocytes, CD4+ T cells, CD8+ T cells, and RTEs were positively associated with TI and TWI. Furthermore, a reduced risk of infections up to age 3 mo was associated with a large thymic size at birth.CONCLUSION: We found no effect of BCG vaccination on thymic size. The positive association between thymic output, lymphocytes, reduced risk of infections, and TI/TWI suggests that assessment of TI/TWI by ultrasound may be a predictor of the immunological capacity in the newborn.

AB - BACKGROUND: The Bacillus Calmette-Guérin vaccine (BCG) has been associated with beneficial nonspecific effects on infant health. We aimed to examine the effect of BCG at birth on thymic size and the associations between thymic output, circulating lymphocytes, risk of infection, and thymic size.METHODS: In infants randomized to BCG or no BCG, thymic index (TI), and thymic/weight index (TWI) were measured by ultrasound at birth and at the age of 3 mo. T cell subpopulations including CD4+ T cells, CD8+ T cells, and recent thymic emigrants (RTEs) were assessed by flow cytometry. Infections up to age 3 mo were parent-reported.RESULTS: BCG vaccination did not affect thymic size at age 3 mo, measured as TI. At birth, the number of lymphocytes, CD4+ T cells, CD8+ T cells, and RTEs were positively associated with TI and TWI. Furthermore, a reduced risk of infections up to age 3 mo was associated with a large thymic size at birth.CONCLUSION: We found no effect of BCG vaccination on thymic size. The positive association between thymic output, lymphocytes, reduced risk of infections, and TI/TWI suggests that assessment of TI/TWI by ultrasound may be a predictor of the immunological capacity in the newborn.

KW - B-Lymphocyte Subsets

KW - BCG Vaccine/administration & dosage

KW - Female

KW - Flow Cytometry

KW - Humans

KW - Infant, Newborn

KW - Male

KW - T-Lymphocyte Subsets

KW - Thymus Gland/anatomy & histology

U2 - 10.1038/pr.2017.27

DO - 10.1038/pr.2017.27

M3 - Journal article

C2 - 28157835

VL - 81

SP - 873

EP - 880

JO - Pediatric Research

JF - Pediatric Research

SN - 0031-3998

IS - 6

ER -