Autophagy in major human diseases

Daniel J Klionsky; Giulia Petroni; Ravi K Amaravadi; Eric H Baehrecke; Andrea Ballabio; Patricia Boya; José Manuel Bravo-San Pedro; Ken Cadwell; Francesco Cecconi; Augustine M K Choi; Mary E Choi; Charleen T Chu; Patrice Codogno; Maria Isabel Colombo; Ana Maria Cuervo; Vojo Deretic; Ivan Dikic; Zvulun Elazar; Eeva-Liisa Eskelinen; Gian Maria Fimia; David A Gewirtz; Douglas R Green; Malene Hansen; Marja Jäättelä; Terje Johansen; Gábor Juhász; Vassiliki Karantza; Claudine Kraft; Guido Kroemer; Nicholas T Ktistakis; Sharad Kumar; Carlos Lopez-Otin; Kay F Macleod; Frank Madeo; Jennifer Martinez; Alicia Meléndez; Noboru Mizushima; Christian Münz; Josef M Penninger; Rushika M Perera; Mauro Piacentini; Fulvio Reggiori; David C Rubinsztein; Kevin M Ryan; Junichi Sadoshima; Laura Santambrogio; Luca Scorrano; Hans-Uwe Simon; Anna Katharina Simon; Anne Simonsen; Alexandra Stolz; Nektarios Tavernarakis; Sharon A Tooze; Tamotsu Yoshimori; Junying Yuan; Zhenyu Yue; Qing Zhong; Lorenzo Galluzzi; Federico Pietrocola

doi:10.15252/embj.2021108863

Autophagy in major human diseases

Daniel J Klionsky, Giulia Petroni, Ravi K Amaravadi, Eric H Baehrecke, Andrea Ballabio, Patricia Boya, José Manuel Bravo-San Pedro, Ken Cadwell, Francesco Cecconi, Augustine M K Choi, Mary E Choi, Charleen T Chu, Patrice Codogno, Maria Isabel Colombo, Ana Maria Cuervo, Vojo Deretic, Ivan Dikic, Zvulun Elazar, Eeva-Liisa Eskelinen, Gian Maria FimiaDavid A Gewirtz, Douglas R Green, Malene Hansen, Marja Jäättelä, Terje Johansen, Gábor Juhász, Vassiliki Karantza, Claudine Kraft, Guido Kroemer, Nicholas T Ktistakis, Sharad Kumar, Carlos Lopez-Otin, Kay F Macleod, Frank Madeo, Jennifer Martinez, Alicia Meléndez, Noboru Mizushima, Christian Münz, Josef M Penninger, Rushika M Perera, Mauro Piacentini, Fulvio Reggiori, David C Rubinsztein, Kevin M Ryan, Junichi Sadoshima, Laura Santambrogio, Luca Scorrano, Hans-Uwe Simon, Anna Katharina Simon, Anne Simonsen, Alexandra Stolz, Nektarios Tavernarakis, Sharon A Tooze, Tamotsu Yoshimori, Junying Yuan, Zhenyu Yue, Qing Zhong, Lorenzo Galluzzi, Federico Pietrocola

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Review › Forskning › peer review

879 Citationer (Scopus)

60 Downloads (Pure)

Abstract

Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.

Originalsprog	Engelsk
Artikelnummer	e108863
Tidsskrift	The EMBO Journal
Vol/bind	40
Nummer	19
Sider (fra-til)	e108863
ISSN	0261-4189
DOI	https://doi.org/10.15252/embj.2021108863
Status	Udgivet - 1 okt. 2021
Udgivet eksternt	Ja

Adgang til dokumentet

10.15252/embj.2021108863Licens: CC BY

The EMBO Journal - 2021 - Klionsky - Autophagy in major human diseasesForlagets udgivne version, 2,11 MBLicens: CC BY

Andre filer og links

Link to publication in Scopus

Citationsformater

Klionsky, D. J., Petroni, G., Amaravadi, R. K., Baehrecke, E. H., Ballabio, A., Boya, P., Bravo-San Pedro, J. M., Cadwell, K., Cecconi, F., Choi, A. M. K., Choi, M. E., Chu, C. T., Codogno, P., Colombo, M. I., Cuervo, A. M., Deretic, V., Dikic, I., Elazar, Z., Eskelinen, E.-L., ... Pietrocola, F. (2021). Autophagy in major human diseases. The EMBO Journal, 40(19), e108863. Artikel e108863. https://doi.org/10.15252/embj.2021108863

@article{584ae1bc318f406f9bdbf1efbfb22279,

title = "Autophagy in major human diseases",

abstract = "Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.",

keywords = "Animals, Autophagy/drug effects, Biomarkers, Disease Susceptibility, Gene Expression Regulation, Genetic Predisposition to Disease, Homeostasis, Host-Pathogen Interactions, Humans, Organ Specificity, Signal Transduction, neurodegeneration, metabolic syndromes, inflammation, cancer, aging",

author = "Klionsky, {Daniel J} and Giulia Petroni and Amaravadi, {Ravi K} and Baehrecke, {Eric H} and Andrea Ballabio and Patricia Boya and {Bravo-San Pedro}, {Jos{\'e} Manuel} and Ken Cadwell and Francesco Cecconi and Choi, {Augustine M K} and Choi, {Mary E} and Chu, {Charleen T} and Patrice Codogno and Colombo, {Maria Isabel} and Cuervo, {Ana Maria} and Vojo Deretic and Ivan Dikic and Zvulun Elazar and Eeva-Liisa Eskelinen and Fimia, {Gian Maria} and Gewirtz, {David A} and Green, {Douglas R} and Malene Hansen and Marja J{\"a}{\"a}ttel{\"a} and Terje Johansen and G{\'a}bor Juh{\'a}sz and Vassiliki Karantza and Claudine Kraft and Guido Kroemer and Ktistakis, {Nicholas T} and Sharad Kumar and Carlos Lopez-Otin and Macleod, {Kay F} and Frank Madeo and Jennifer Martinez and Alicia Mel{\'e}ndez and Noboru Mizushima and Christian M{\"u}nz and Penninger, {Josef M} and Perera, {Rushika M} and Mauro Piacentini and Fulvio Reggiori and Rubinsztein, {David C} and Ryan, {Kevin M} and Junichi Sadoshima and Laura Santambrogio and Luca Scorrano and Hans-Uwe Simon and Simon, {Anna Katharina} and Anne Simonsen and Alexandra Stolz and Nektarios Tavernarakis and Tooze, {Sharon A} and Tamotsu Yoshimori and Junying Yuan and Zhenyu Yue and Qing Zhong and Lorenzo Galluzzi and Federico Pietrocola",

note = "{\textcopyright} 2021 The Authors. Published under the terms of the CC BY 4.0 license.",

year = "2021",

month = oct,

day = "1",

doi = "10.15252/embj.2021108863",

language = "English",

volume = "40",

pages = "e108863",

journal = "The EMBO Journal",

issn = "0261-4189",

publisher = "EMBO Press",

number = "19",

}

Klionsky, DJ, Petroni, G, Amaravadi, RK, Baehrecke, EH, Ballabio, A, Boya, P, Bravo-San Pedro, JM, Cadwell, K, Cecconi, F, Choi, AMK, Choi, ME, Chu, CT, Codogno, P, Colombo, MI, Cuervo, AM, Deretic, V, Dikic, I, Elazar, Z, Eskelinen, E-L, Fimia, GM, Gewirtz, DA, Green, DR, Hansen, M, Jäättelä, M, Johansen, T, Juhász, G, Karantza, V, Kraft, C, Kroemer, G, Ktistakis, NT, Kumar, S, Lopez-Otin, C, Macleod, KF, Madeo, F, Martinez, J, Meléndez, A, Mizushima, N, Münz, C, Penninger, JM, Perera, RM, Piacentini, M, Reggiori, F, Rubinsztein, DC, Ryan, KM, Sadoshima, J, Santambrogio, L, Scorrano, L, Simon, H-U, Simon, AK, Simonsen, A, Stolz, A, Tavernarakis, N, Tooze, SA, Yoshimori, T, Yuan, J, Yue, Z, Zhong, Q, Galluzzi, L & Pietrocola, F 2021, 'Autophagy in major human diseases', The EMBO Journal, bind 40, nr. 19, e108863, s. e108863. https://doi.org/10.15252/embj.2021108863

TY - JOUR

T1 - Autophagy in major human diseases

AU - Klionsky, Daniel J

AU - Petroni, Giulia

AU - Amaravadi, Ravi K

AU - Baehrecke, Eric H

AU - Ballabio, Andrea

AU - Boya, Patricia

AU - Bravo-San Pedro, José Manuel

AU - Cadwell, Ken

AU - Cecconi, Francesco

AU - Choi, Augustine M K

AU - Choi, Mary E

AU - Chu, Charleen T

AU - Codogno, Patrice

AU - Colombo, Maria Isabel

AU - Cuervo, Ana Maria

AU - Deretic, Vojo

AU - Dikic, Ivan

AU - Elazar, Zvulun

AU - Eskelinen, Eeva-Liisa

AU - Fimia, Gian Maria

AU - Gewirtz, David A

AU - Green, Douglas R

AU - Hansen, Malene

AU - Jäättelä, Marja

AU - Johansen, Terje

AU - Juhász, Gábor

AU - Karantza, Vassiliki

AU - Kraft, Claudine

AU - Kroemer, Guido

AU - Ktistakis, Nicholas T

AU - Kumar, Sharad

AU - Lopez-Otin, Carlos

AU - Macleod, Kay F

AU - Madeo, Frank

AU - Martinez, Jennifer

AU - Meléndez, Alicia

AU - Mizushima, Noboru

AU - Münz, Christian

AU - Penninger, Josef M

AU - Perera, Rushika M

AU - Piacentini, Mauro

AU - Reggiori, Fulvio

AU - Rubinsztein, David C

AU - Ryan, Kevin M

AU - Sadoshima, Junichi

AU - Santambrogio, Laura

AU - Scorrano, Luca

AU - Simon, Hans-Uwe

AU - Simon, Anna Katharina

AU - Simonsen, Anne

AU - Stolz, Alexandra

AU - Tavernarakis, Nektarios

AU - Tooze, Sharon A

AU - Yoshimori, Tamotsu

AU - Yuan, Junying

AU - Yue, Zhenyu

AU - Zhong, Qing

AU - Galluzzi, Lorenzo

AU - Pietrocola, Federico

PY - 2021/10/1

Y1 - 2021/10/1

N2 - Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.

AB - Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.

KW - Animals

KW - Autophagy/drug effects

KW - Biomarkers

KW - Disease Susceptibility

KW - Gene Expression Regulation

KW - Genetic Predisposition to Disease

KW - Homeostasis

KW - Host-Pathogen Interactions

KW - Humans

KW - Organ Specificity

KW - Signal Transduction

KW - neurodegeneration

KW - metabolic syndromes

KW - inflammation

KW - cancer

KW - aging

UR - http://www.scopus.com/inward/record.url?scp=85113807620&partnerID=8YFLogxK

U2 - 10.15252/embj.2021108863

DO - 10.15252/embj.2021108863

M3 - Review

C2 - 34459017

SN - 0261-4189

VL - 40

SP - e108863

JO - The EMBO Journal

JF - The EMBO Journal

IS - 19

M1 - e108863

ER -

Autophagy in major human diseases

Abstract

Adgang til dokumentet

Andre filer og links

Fingeraftryk

Citationsformater