Autophagy as an innate immunity response against pathogens: a Tango dance

TY - JOUR

T1 - Autophagy as an innate immunity response against pathogens

T2 - a Tango dance

AU - Aguilera, Milton O

AU - Delgui, Laura R

AU - Reggiori, Fulvio

AU - Romano, Patricia S

AU - Colombo, María I

N1 - This article is protected by copyright. All rights reserved.

PY - 2024/1

Y1 - 2024/1

N2 - Intracellular infections as well as changes in the cell nutritional environment are main events that trigger cellular stress responses. One crucial cell response to stress conditions is autophagy. During the last 30 years, several scenarios involving autophagy induction or inhibition over the course of an intracellular invasion by pathogens have been uncovered. In this review, we will present how this knowledge was gained by studying different microorganisms. We intend to discuss how the cell, via autophagy, tries to repel these attacks with the objective of destroying the intruder, but also how some pathogens have developed strategies to subvert this. These two fates can be compared with a Tango, a dance originated in Buenos Aires, Argentina, in which the partner dancers are in close connection. One of them is the leader, embracing and involving the partner, but the follower may respond escaping from the leader. This joint dance is indeed highly synchronized and controlled, perfectly reflecting the interaction between autophagy and microorganism.

AB - Intracellular infections as well as changes in the cell nutritional environment are main events that trigger cellular stress responses. One crucial cell response to stress conditions is autophagy. During the last 30 years, several scenarios involving autophagy induction or inhibition over the course of an intracellular invasion by pathogens have been uncovered. In this review, we will present how this knowledge was gained by studying different microorganisms. We intend to discuss how the cell, via autophagy, tries to repel these attacks with the objective of destroying the intruder, but also how some pathogens have developed strategies to subvert this. These two fates can be compared with a Tango, a dance originated in Buenos Aires, Argentina, in which the partner dancers are in close connection. One of them is the leader, embracing and involving the partner, but the follower may respond escaping from the leader. This joint dance is indeed highly synchronized and controlled, perfectly reflecting the interaction between autophagy and microorganism.

KW - ATG

KW - LAP

KW - LC3

KW - autophagy

KW - intracellular microorganisms

KW - invading bacteria

KW - parasites

KW - viruses

KW - Dancing

KW - Immunity, Innate

KW - Autophagy

U2 - 10.1002/1873-3468.14788

DO - 10.1002/1873-3468.14788

M3 - Review

C2 - 38101809

SN - 0014-5793

VL - 598

SP - 140

EP - 166

JO - FEBS Letters

JF - FEBS Letters

IS - 1

ER -