Abstract
Macroautophagy, or simply autophagy, is a degradative pathway that delivers cytoplasmic components, including cytosol and organelles, to the lysosome in double-membrane vesicles called autophagosomes. This process is initiated at the pre-autophagosomal structure or phagophore assembly site and involves a number of highly conserved autophagy-related proteins. These support the generation and conversion of an open membranous cistern known as the phagophore or isolation membrane into a closed autophagosome. Within this review, we will focus on recent insights into the molecular events following the sealing/completion of an autophagosome, which lead to its maturation and subsequent fusion with endosomes/lysosomes.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Journal of Molecular Biology |
| Vol/bind | 429 |
| Nummer | 4 |
| Sider (fra-til) | 486-496 |
| Antal sider | 11 |
| ISSN | 0022-2836 |
| DOI | |
| Status | Udgivet - 17 feb. 2017 |
| Udgivet eksternt | Ja |