TY - JOUR
T1 - Atopic dermatitis in childhood and pubertal development
T2 - A nationwide cohort study
AU - Kjersgaard, Camilla Lomholt
AU - Ernst, Andreas
AU - Clemmensen, Pernille Jul
AU - Harrits Lunddorf, Lea Lykke
AU - Arendt, Linn Håkonsen
AU - Brix, Nis
AU - Arah, Onyebuchi A
AU - Deleuran, Mette
AU - Ramlau-Hansen, Cecilia Høst
N1 - © 2024 by the American Academy of Dermatology, Inc. Published by Elsevier Inc.
PY - 2025/4
Y1 - 2025/4
N2 - Background: Atopic dermatitis (AD) might delay puberty, but research is lacking. Objective: To investigate the association between AD and puberty. Methods: A subcohort within the Danish National Birth Cohort includes children born between 2000 and 2003, with mothers reporting doctor-diagnosed AD at 6 months, 18 months, and 7 years old. The National Patient Registry identified hospital-diagnosed AD. From 11 years, the children give half-yearly information on pubertal development. We estimated the mean age difference in months at attaining Tanner stages 1 to 5 and the development of axillary hair, acne, first ejaculation, voice break, and age at menarche, using an interval-censored regression model. Results: In total, 15,534 children participated, 21.5% had self-reported doctor-diagnosed AD and 0.7% had hospital-diagnosed AD. For girls with self-reported doctor-diagnosed AD, the average age difference at reaching all pubertal milestones was 0.0 months (95% confidence interval [CI]: −0.8; 0.8), and for hospital-diagnosed AD, it was −0.3 months (95% CI: −5.4; 4.8). For boys, the average age difference was 0.1 months (95% CI: −0.6; 0.9) and −0.3 months (95% CI: −3.6; 3.0), respectively. Limitations: No information on treatment was available. Missing data on covariates (<5%) were not addressed. Conclusion: No association was found between AD and puberty in either girls or boys.
AB - Background: Atopic dermatitis (AD) might delay puberty, but research is lacking. Objective: To investigate the association between AD and puberty. Methods: A subcohort within the Danish National Birth Cohort includes children born between 2000 and 2003, with mothers reporting doctor-diagnosed AD at 6 months, 18 months, and 7 years old. The National Patient Registry identified hospital-diagnosed AD. From 11 years, the children give half-yearly information on pubertal development. We estimated the mean age difference in months at attaining Tanner stages 1 to 5 and the development of axillary hair, acne, first ejaculation, voice break, and age at menarche, using an interval-censored regression model. Results: In total, 15,534 children participated, 21.5% had self-reported doctor-diagnosed AD and 0.7% had hospital-diagnosed AD. For girls with self-reported doctor-diagnosed AD, the average age difference at reaching all pubertal milestones was 0.0 months (95% confidence interval [CI]: −0.8; 0.8), and for hospital-diagnosed AD, it was −0.3 months (95% CI: −5.4; 4.8). For boys, the average age difference was 0.1 months (95% CI: −0.6; 0.9) and −0.3 months (95% CI: −3.6; 3.0), respectively. Limitations: No information on treatment was available. Missing data on covariates (<5%) were not addressed. Conclusion: No association was found between AD and puberty in either girls or boys.
KW - Tanner stages
KW - atopic dermatitis
KW - atopy
KW - cohort study
KW - eczema
KW - epidemiology
KW - menarche
KW - pubertal development
KW - pubertal milestones
KW - puberty
UR - http://www.scopus.com/inward/record.url?scp=85215403377&partnerID=8YFLogxK
U2 - 10.1016/j.jdin.2024.09.018
DO - 10.1016/j.jdin.2024.09.018
M3 - Journal article
C2 - 39898017
SN - 2666-3287
VL - 19
SP - 21
EP - 31
JO - JAAD International
JF - JAAD International
ER -