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Atopic dermatitis and risk of atrial fibrillation or flutter: a 35-year follow-up study

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Atopic dermatitis and risk of atrial fibrillation or flutter : a 35-year follow-up study. / Schmidt, Sigrun A J; Olsen, Morten; Schmidt, Morten; Vestergaard, Christian; Langan, Sinéad M; Deleuran, Mette S; Riis, Jette L.

I: Journal of the American Academy of Dermatology, Bind 83, Nr. 6, 12.2020, s. 1616-1624.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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Schmidt, Sigrun A J ; Olsen, Morten ; Schmidt, Morten ; Vestergaard, Christian ; Langan, Sinéad M ; Deleuran, Mette S ; Riis, Jette L. / Atopic dermatitis and risk of atrial fibrillation or flutter : a 35-year follow-up study. I: Journal of the American Academy of Dermatology. 2020 ; Bind 83, Nr. 6. s. 1616-1624.

Bibtex

@article{53e572a771c240bdb02aa28fb52939ed,
title = "Atopic dermatitis and risk of atrial fibrillation or flutter: a 35-year follow-up study",
abstract = "BACKGROUND: Atopic dermatitis is characterized by chronic inflammation, which is a risk factor for atrial fibrillation.OBJECTIVE: To examine the association between hospital-diagnosed atopic dermatitis and atrial fibrillation.METHODS: Using linked population-based Danish registries, we identified persons with an inpatient or outpatient hospital diagnosis of atopic dermatitis during 1977-2013 and a comparison cohort individually matched to the atopic dermatitis cohort. We followed cohorts until death, emigration, atrial fibrillation diagnosis, or end of study (January 1, 2013). We compared 35-year risk of atrial fibrillation and estimated hazard ratios with 95% confidence intervals using Cox regression, adjusting for birth year and sex. We validated 100 atopic dermatitis diagnoses from a dermatologic department through medical record review.RESULTS: We included 13,126 persons with atopic dermatitis and 124,211 comparators and followed them for a median of 19.3 years. The 35-year risk of atrial fibrillation was 0.81% and 0.67%, respectively. The positive predictive value of atopic dermatitis diagnoses was 99%. The hazard ratio was 1.2 (95% confidence interval 1.0-1.6) and remained increased after adjusting for various atrial fibrillation risk factors.LIMITATIONS: Analyses were limited to persons with moderate-to-severe atopic dermatitis, and we had no lifestyle data.CONCLUSION: Patients with hospital-diagnosed atopic dermatitis have a 20% increased long-term risk of atrial fibrillation, but the absolute risk remains low.",
author = "Schmidt, {Sigrun A J} and Morten Olsen and Morten Schmidt and Christian Vestergaard and Langan, {Sin{\'e}ad M} and Deleuran, {Mette S} and Riis, {Jette L}",
year = "2020",
month = dec,
doi = "10.1016/j.jaad.2019.08.039",
language = "English",
volume = "83",
pages = "1616--1624",
journal = "American Academy of Dermatology. Journal",
issn = "0190-9622",
publisher = "Mosby, Inc",
number = "6",

}

RIS

TY - JOUR

T1 - Atopic dermatitis and risk of atrial fibrillation or flutter

T2 - a 35-year follow-up study

AU - Schmidt, Sigrun A J

AU - Olsen, Morten

AU - Schmidt, Morten

AU - Vestergaard, Christian

AU - Langan, Sinéad M

AU - Deleuran, Mette S

AU - Riis, Jette L

PY - 2020/12

Y1 - 2020/12

N2 - BACKGROUND: Atopic dermatitis is characterized by chronic inflammation, which is a risk factor for atrial fibrillation.OBJECTIVE: To examine the association between hospital-diagnosed atopic dermatitis and atrial fibrillation.METHODS: Using linked population-based Danish registries, we identified persons with an inpatient or outpatient hospital diagnosis of atopic dermatitis during 1977-2013 and a comparison cohort individually matched to the atopic dermatitis cohort. We followed cohorts until death, emigration, atrial fibrillation diagnosis, or end of study (January 1, 2013). We compared 35-year risk of atrial fibrillation and estimated hazard ratios with 95% confidence intervals using Cox regression, adjusting for birth year and sex. We validated 100 atopic dermatitis diagnoses from a dermatologic department through medical record review.RESULTS: We included 13,126 persons with atopic dermatitis and 124,211 comparators and followed them for a median of 19.3 years. The 35-year risk of atrial fibrillation was 0.81% and 0.67%, respectively. The positive predictive value of atopic dermatitis diagnoses was 99%. The hazard ratio was 1.2 (95% confidence interval 1.0-1.6) and remained increased after adjusting for various atrial fibrillation risk factors.LIMITATIONS: Analyses were limited to persons with moderate-to-severe atopic dermatitis, and we had no lifestyle data.CONCLUSION: Patients with hospital-diagnosed atopic dermatitis have a 20% increased long-term risk of atrial fibrillation, but the absolute risk remains low.

AB - BACKGROUND: Atopic dermatitis is characterized by chronic inflammation, which is a risk factor for atrial fibrillation.OBJECTIVE: To examine the association between hospital-diagnosed atopic dermatitis and atrial fibrillation.METHODS: Using linked population-based Danish registries, we identified persons with an inpatient or outpatient hospital diagnosis of atopic dermatitis during 1977-2013 and a comparison cohort individually matched to the atopic dermatitis cohort. We followed cohorts until death, emigration, atrial fibrillation diagnosis, or end of study (January 1, 2013). We compared 35-year risk of atrial fibrillation and estimated hazard ratios with 95% confidence intervals using Cox regression, adjusting for birth year and sex. We validated 100 atopic dermatitis diagnoses from a dermatologic department through medical record review.RESULTS: We included 13,126 persons with atopic dermatitis and 124,211 comparators and followed them for a median of 19.3 years. The 35-year risk of atrial fibrillation was 0.81% and 0.67%, respectively. The positive predictive value of atopic dermatitis diagnoses was 99%. The hazard ratio was 1.2 (95% confidence interval 1.0-1.6) and remained increased after adjusting for various atrial fibrillation risk factors.LIMITATIONS: Analyses were limited to persons with moderate-to-severe atopic dermatitis, and we had no lifestyle data.CONCLUSION: Patients with hospital-diagnosed atopic dermatitis have a 20% increased long-term risk of atrial fibrillation, but the absolute risk remains low.

U2 - 10.1016/j.jaad.2019.08.039

DO - 10.1016/j.jaad.2019.08.039

M3 - Journal article

C2 - 31442537

VL - 83

SP - 1616

EP - 1624

JO - American Academy of Dermatology. Journal

JF - American Academy of Dermatology. Journal

SN - 0190-9622

IS - 6

ER -