Associations of Preconception Exposure to Air Pollution and Greenness with Offspring Asthma and Hay Fever

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  • Ingrid Nordeide Kuiper, Department of Occupational Medicine, Haukeland University Hospital, Bergen, Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norge
  • Iana Markevych, Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital of Ludwig Maximilians University, Comprehensive Pneumology Centre Munich, German Centre for Lung Research, Munich, Germany., Applied Memory Research Laboratory, Institute of Psychology, Jagiellonian University, Krakow, Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Tyskland
  • Simone Accordini, Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy., Italien
  • Randi J Bertelsen, Department of Clinical Science, University of Bergen, Oral Health Centre of Expertise in Western Norway, Bergen, Norge
  • Lennart Bråbäck, Section of Sustainable Medicine, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sverige
  • Jesper Heile Christensen
  • Bertil Forsberg, Section of Sustainable Medicine, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sverige
  • Thomas Halvorsen, Department of Clinical Science, University of Bergen, Norge
  • Joachim Heinrich, Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, Ludwig Maximilian University of Munich, Allergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne, Australia., Tyskland
  • Ole Hertel
  • Gerard Hoek, Utrecht University, Holland
  • Mathias Holm, Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital and Academy. Gothenburg, Sverige
  • Kees de Hoogh, Swiss Tropical and Public Health Institute (Swiss TPH), University of Basel, Basel, Switzerland, Schweiz
  • Christer Janson, Department of Medical Sciences, Respiratory-, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden., Sverige
  • Andrei Malinovschi, Uppsala University and Uppsala Clinical Research Center, Uppsala University, Sweden., Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden., Sverige
  • Alessandro Marcon, Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy., Italien
  • Torben Sigsgaard
  • Cecilie Svanes, Department of Occupational Medicine, Haukeland University Hospital, Bergen, Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norge
  • Ane Johannessen, Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norge

We investigated if greenness and air pollution exposure in parents' childhood affect offspring asthma and hay fever, and if effects were mediated through parental asthma, pregnancy greenness/pollution exposure, and offspring exposure. We analysed 1106 parents with 1949 offspring (mean age 35 and 6) from the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) generation study. Mean particulate matter (PM2.5 and PM10), nitrogen dioxide (NO2), black carbon (BC), ozone (O3) (µg/m3) and greenness (normalized difference vegetation index (NDVI)) were calculated for parents 0-18 years old and offspring 0-10 years old, and were categorised in tertiles. We performed logistic regression and mediation analyses for two-pollutant models (clustered by family and centre, stratified by parental lines, and adjusted for grandparental asthma and education). Maternal medium PM2.5 and PM10 exposure was associated with higher offspring asthma risk (odds ratio (OR) 2.23, 95%CI 1.32-3.78, OR 2.27, 95%CI 1.36-3.80), and paternal high BC exposure with lower asthma risk (OR 0.31, 95%CI 0.11-0.87). Hay fever risk increased for offspring of fathers with medium O3 exposure (OR 4.15, 95%CI 1.28-13.50) and mothers with high PM10 exposure (OR 2.66, 95%CI 1.19-5.91). The effect of maternal PM10 exposure on offspring asthma was direct, while for hay fever, it was mediated through exposures in pregnancy and offspring's own exposures. Paternal O3 exposure had a direct effect on offspring hay fever. To conclude, parental exposure to air pollution appears to influence the risk of asthma and allergies in future offspring.

OriginalsprogEngelsk
Artikelnummer5828
TidsskriftInternational Journal of Environmental Research and Public Health
Vol/bind17
Nummer16
Antal sider14
ISSN1661-7827
DOI
StatusUdgivet - 2020

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