Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

  • Anna Sokołowska, Polish Academy of Sciences
  • ,
  • Anna S Świerzko, Polish Academy of Sciences
  • ,
  • Gabriela Gajek, Polish Academy of Sciences
  • ,
  • Aleksandra Gołos, Institute of Hematology and Transfusion Medicine
  • ,
  • Mateusz Michalski, Polish Academy of Sciences
  • ,
  • Mateusz Nowicki, Department of Hematology, Copernicus Memorial Hospital in Łódź Comprehensive Cancer Center and Traumatology, Łódź, Poland.
  • ,
  • Agnieszka Szala-Poździej, Polish Academy of Sciences
  • ,
  • Anna Wolska-Washer, Medical University of Lódz
  • ,
  • Olga Brzezińska, Medical University of Lódz
  • ,
  • Agnieszka Wierzbowska, Medical University of Lódz
  • ,
  • Krzysztof Jamroziak, Institute of Hematology and Transfusion Medicine
  • ,
  • Marek L Kowalski, Medical University of Lódz
  • ,
  • Steffen Thiel
  • Misao Matsushita, Tokai University
  • ,
  • Jens C Jensenius
  • Maciej Cedzyński, Polish Academy of Sciences

We investigated clinical associations of ficolins and mannose-binding lectin (MBL) in 157 patients suffering from acute myeloid leukaemia (AML). Concentrations of ficolin-1, ficolin-2, ficolin-3 and MBL (before chemotherapy) in serum were determined as were selected polymorphisms of the corresponding genes (FCN1, FCN2, FCN3 and MBL2). The control group (C) consisted of 267 healthy unrelated individuals. Median level of ficolin-1 in patients was lower (p < 0.000001) while median levels of ficolin-2, ficolin-3 and MBL were higher (p < 0.000001, p < 0.000001 and p = 0.0016, respectively) compared with controls. These findings were generally associated with AML itself, however the highest MBL levels predicted higher risk of severe hospital infections (accompanied with bacteremia and/or fungaemia) (p = 0.012) while the lowest ficolin-1 concentrations tended to be associated with prolonged (> 7 days) fever (p = 0.026). Genotyping indicated an association of G/G homozygosity (corresponding to FCN1 gene - 542 G > A polymorphism) with malignancy [p = 0.004, OR = 2.95, 95% CI (1.41-6.16)]. Based on ROC analysis, ficolin-1, -2 and -3 may be considered candidate supplementary biomarkers of AML. Their high potential to differentiate between patients from non-malignant controls but also from persons suffering from other haematological cancers (multiple myeloma and lymphoma) was demonstrated.

OriginalsprogEngelsk
Artikelnummer10561
TidsskriftScientific Reports
Vol/bind10
ISSN2045-2322
DOI
StatusUdgivet - jun. 2020

Se relationer på Aarhus Universitet Citationsformater

ID: 191525344