Associations between patient-reported outcomes and radiation dose in patients treated with radiation therapy for primary brain tumours

L Haldbo-Classen; A Amidi; L M Wu; S Lukacova; G Oettingen; Y Lassen-Ramshad; R Zachariae; J F Kallehauge; M Høyer

doi:10.1016/j.ctro.2021.09.006

Associations between patient-reported outcomes and radiation dose in patients treated with radiation therapy for primary brain tumours

L Haldbo-Classen^*, A Amidi, L M Wu, S Lukacova, G Oettingen, Y Lassen-Ramshad, R Zachariae, J F Kallehauge, M Høyer

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Abstract

Aim: This study aimed to explore associations between radiation dose and patient-reported outcomes in patients with a primary non-glioblastoma brain tumour treated with radiation therapy (RT), with a focus on health-related quality-of-life (HRQoL) and self-reported cognitive function. Methods: In this cross-sectional study, 78 patients who had received RT for a non-glioblastoma primary brain tumour, underwent neuropsychological testing and completed questionnaires on HRQoL, cognitive function, fatigue, depression, anxiety and perceived stress. The study explores the association between HRQoL scores, self-reported cognitive function and radiation doses to total brain, brainstem, hippocampus, thalamus, temporal lobes and frontal lobes. In addition, we examined correlations between neuropsychological test scores and self-reported cognitive function. Results: The median time between RT and testing was 4.6 years (range 1–9 years). Patients who had received high mean radiation doses to the total brain had low HRQoL scores (Cohen's d = 0.50, p = 0.04), brainstem (d = 0.65, p = 0.01) and hippocampus (d = 0.66, p = 0.01). High mean doses to the total brain were also associated with low scores on self-reported cognitive functioning (Cohen's d = 0.64, p = 0.02), brainstem (d = 0.55, p = 0.03), hippocampus (d = 0.76, p < 0.01), temporal lobes (d = 0.70, p < 0.01) and thalamus (d = 0.64, p = 0.01). Self-reported cognitive function correlated well with neuropsychological test scores (correlation range 0.27–0.54.) Conclusions: High radiation doses to specific brain structures may be associated with impaired HRQoL and self-reported cognitive function with potentially negative implications to patients’ daily lives. Patient-reported outcomes of treatment-related side-effects and their associations with radiation doses to the brain and its sub-structures may provide important information on radiation tolerance to the brain and sub-structures.

Originalsprog	Engelsk
Tidsskrift	Clinical and Translational Radiation Oncology
Vol/bind	31
Sider (fra-til)	86-92
Antal sider	7
ISSN	2405-6308
DOI	https://doi.org/10.1016/j.ctro.2021.09.006
Status	Udgivet - nov. 2021

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10.1016/j.ctro.2021.09.006Licens: CC BY-NC-ND

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Haldbo-Classen, L., Amidi, A., Wu, L. M., Lukacova, S., Oettingen, G., Lassen-Ramshad, Y., Zachariae, R., Kallehauge, J. F., & Høyer, M. (2021). Associations between patient-reported outcomes and radiation dose in patients treated with radiation therapy for primary brain tumours. Clinical and Translational Radiation Oncology, 31, 86-92. https://doi.org/10.1016/j.ctro.2021.09.006

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title = "Associations between patient-reported outcomes and radiation dose in patients treated with radiation therapy for primary brain tumours",

abstract = "Aim: This study aimed to explore associations between radiation dose and patient-reported outcomes in patients with a primary non-glioblastoma brain tumour treated with radiation therapy (RT), with a focus on health-related quality-of-life (HRQoL) and self-reported cognitive function. Methods: In this cross-sectional study, 78 patients who had received RT for a non-glioblastoma primary brain tumour, underwent neuropsychological testing and completed questionnaires on HRQoL, cognitive function, fatigue, depression, anxiety and perceived stress. The study explores the association between HRQoL scores, self-reported cognitive function and radiation doses to total brain, brainstem, hippocampus, thalamus, temporal lobes and frontal lobes. In addition, we examined correlations between neuropsychological test scores and self-reported cognitive function. Results: The median time between RT and testing was 4.6 years (range 1–9 years). Patients who had received high mean radiation doses to the total brain had low HRQoL scores (Cohen's d = 0.50, p = 0.04), brainstem (d = 0.65, p = 0.01) and hippocampus (d = 0.66, p = 0.01). High mean doses to the total brain were also associated with low scores on self-reported cognitive functioning (Cohen's d = 0.64, p = 0.02), brainstem (d = 0.55, p = 0.03), hippocampus (d = 0.76, p < 0.01), temporal lobes (d = 0.70, p < 0.01) and thalamus (d = 0.64, p = 0.01). Self-reported cognitive function correlated well with neuropsychological test scores (correlation range 0.27–0.54.) Conclusions: High radiation doses to specific brain structures may be associated with impaired HRQoL and self-reported cognitive function with potentially negative implications to patients{\textquoteright} daily lives. Patient-reported outcomes of treatment-related side-effects and their associations with radiation doses to the brain and its sub-structures may provide important information on radiation tolerance to the brain and sub-structures.",

keywords = "Brain tumor, Cognition, Patient-reported outcomes, Quality of life, Radiation therapy",

author = "L Haldbo-Classen and A Amidi and Wu, {L M} and S Lukacova and G Oettingen and Y Lassen-Ramshad and R Zachariae and Kallehauge, {J F} and M H{\o}yer",

year = "2021",

month = nov,

doi = "10.1016/j.ctro.2021.09.006",

language = "English",

volume = "31",

pages = "86--92",

journal = "Clinical and Translational Radiation Oncology",

issn = "2405-6308",

publisher = "Elsevier",

}

Haldbo-Classen, L , Amidi, A , Wu, LM , Lukacova, S , Oettingen, G, Lassen-Ramshad, Y, Zachariae, R , Kallehauge, JF & Høyer, M 2021, 'Associations between patient-reported outcomes and radiation dose in patients treated with radiation therapy for primary brain tumours', Clinical and Translational Radiation Oncology, bind 31, s. 86-92. https://doi.org/10.1016/j.ctro.2021.09.006

Associations between patient-reported outcomes and radiation dose in patients treated with radiation therapy for primary brain tumours. / Haldbo-Classen, L ; Amidi, A ; Wu, L M et al.
I: Clinical and Translational Radiation Oncology, Bind 31, 11.2021, s. 86-92.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - Associations between patient-reported outcomes and radiation dose in patients treated with radiation therapy for primary brain tumours

AU - Haldbo-Classen, L

AU - Amidi, A

AU - Wu, L M

AU - Lukacova, S

AU - Oettingen, G

AU - Lassen-Ramshad, Y

AU - Zachariae, R

AU - Kallehauge, J F

AU - Høyer, M

PY - 2021/11

Y1 - 2021/11

N2 - Aim: This study aimed to explore associations between radiation dose and patient-reported outcomes in patients with a primary non-glioblastoma brain tumour treated with radiation therapy (RT), with a focus on health-related quality-of-life (HRQoL) and self-reported cognitive function. Methods: In this cross-sectional study, 78 patients who had received RT for a non-glioblastoma primary brain tumour, underwent neuropsychological testing and completed questionnaires on HRQoL, cognitive function, fatigue, depression, anxiety and perceived stress. The study explores the association between HRQoL scores, self-reported cognitive function and radiation doses to total brain, brainstem, hippocampus, thalamus, temporal lobes and frontal lobes. In addition, we examined correlations between neuropsychological test scores and self-reported cognitive function. Results: The median time between RT and testing was 4.6 years (range 1–9 years). Patients who had received high mean radiation doses to the total brain had low HRQoL scores (Cohen's d = 0.50, p = 0.04), brainstem (d = 0.65, p = 0.01) and hippocampus (d = 0.66, p = 0.01). High mean doses to the total brain were also associated with low scores on self-reported cognitive functioning (Cohen's d = 0.64, p = 0.02), brainstem (d = 0.55, p = 0.03), hippocampus (d = 0.76, p < 0.01), temporal lobes (d = 0.70, p < 0.01) and thalamus (d = 0.64, p = 0.01). Self-reported cognitive function correlated well with neuropsychological test scores (correlation range 0.27–0.54.) Conclusions: High radiation doses to specific brain structures may be associated with impaired HRQoL and self-reported cognitive function with potentially negative implications to patients’ daily lives. Patient-reported outcomes of treatment-related side-effects and their associations with radiation doses to the brain and its sub-structures may provide important information on radiation tolerance to the brain and sub-structures.

AB - Aim: This study aimed to explore associations between radiation dose and patient-reported outcomes in patients with a primary non-glioblastoma brain tumour treated with radiation therapy (RT), with a focus on health-related quality-of-life (HRQoL) and self-reported cognitive function. Methods: In this cross-sectional study, 78 patients who had received RT for a non-glioblastoma primary brain tumour, underwent neuropsychological testing and completed questionnaires on HRQoL, cognitive function, fatigue, depression, anxiety and perceived stress. The study explores the association between HRQoL scores, self-reported cognitive function and radiation doses to total brain, brainstem, hippocampus, thalamus, temporal lobes and frontal lobes. In addition, we examined correlations between neuropsychological test scores and self-reported cognitive function. Results: The median time between RT and testing was 4.6 years (range 1–9 years). Patients who had received high mean radiation doses to the total brain had low HRQoL scores (Cohen's d = 0.50, p = 0.04), brainstem (d = 0.65, p = 0.01) and hippocampus (d = 0.66, p = 0.01). High mean doses to the total brain were also associated with low scores on self-reported cognitive functioning (Cohen's d = 0.64, p = 0.02), brainstem (d = 0.55, p = 0.03), hippocampus (d = 0.76, p < 0.01), temporal lobes (d = 0.70, p < 0.01) and thalamus (d = 0.64, p = 0.01). Self-reported cognitive function correlated well with neuropsychological test scores (correlation range 0.27–0.54.) Conclusions: High radiation doses to specific brain structures may be associated with impaired HRQoL and self-reported cognitive function with potentially negative implications to patients’ daily lives. Patient-reported outcomes of treatment-related side-effects and their associations with radiation doses to the brain and its sub-structures may provide important information on radiation tolerance to the brain and sub-structures.

KW - Brain tumor

KW - Cognition

KW - Patient-reported outcomes

KW - Quality of life

KW - Radiation therapy

UR - http://www.scopus.com/inward/record.url?scp=85122824260&partnerID=8YFLogxK

U2 - 10.1016/j.ctro.2021.09.006

DO - 10.1016/j.ctro.2021.09.006

M3 - Journal article

C2 - 34693039

SN - 2405-6308

VL - 31

SP - 86

EP - 92

JO - Clinical and Translational Radiation Oncology

JF - Clinical and Translational Radiation Oncology

ER -

Associations between patient-reported outcomes and radiation dose in patients treated with radiation therapy for primary brain tumours

Abstract

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