Association of plasma biomarkers of fruit and vegetable intake with incident type 2 diabetes: EPIC-InterAct case-cohort study in eight European countries

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

  • Ju-Sheng Zheng, University of Cambridge, School of Clinical Medicine., Westlake University, Storbritannien
  • Stephen J Sharp, University of Cambridge, School of Clinical Medicine., Storbritannien
  • Fumiaki Imamura, University of Cambridge, School of Clinical Medicine., Storbritannien
  • Rajiv Chowdhury, University of Cambridge, Storbritannien
  • Thomas E Gundersen, Vitas AS, Oslo, Norway., Norge
  • Marinka Steur, University of Cambridge, School of Clinical Medicine., Storbritannien
  • Ivonne Sluijs, Utrecht University, Holland
  • Yvonne T van der Schouw, Utrecht University, Holland
  • Antonio Agudo, Catalan Institute of Oncology, Barcelona, Spanien
  • Dagfinn Aune, Bjørknes University College, Oslo University Hospital, Imperial College, London, Storbritannien
  • Aurelio Barricarte, Navarra Public Health Institute, Spanien
  • Heiner Boeing, German Institute of Human Nutrition Potsdam-Rehbruecke, Tyskland
  • María-Dolores Chirlaque, University Murcia, CIBERESP, Consortium for Biomedical Research in Epidemiology and Public Health, Spanien
  • Miren Dorronsoro, Public Health Division of Gipuzkoa, San Sebastian, Spain., Spanien
  • Heinz Freisling, International Agency for Research on Cancer Lyon, France., Frankrig
  • Douae El-Fatouhi, University Paris-Saclay, University Paris-Sud, Villejuif, Frankrig
  • Paul W Franks, Department of Nephrology in Lund, Clinical Sciences Lund, Skåne University Hospital and Lund University, Lund, Sweden., Lund University, Sverige
  • Guy Fagherazzi, University Paris-Saclay, University Paris-Sud, Villejuif, Luxembourg Institute of Health (LIH), Department of Population Health, Strassen, Frankrig
  • Sara Grioni, Epidemiology and Prevention Unit, Milan, Italy., Italien
  • Marc J Gunter, International Agency for Research on Cancer
  • ,
  • Cecilie Kyrø, Danish Cancer Society Research Centre, Copenhagen, Denmark., Danmark
  • Verena Katzke, Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany., Tyskland
  • Tilman Kühn, Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany., Tyskland
  • Kay-Tee Khaw, University of Cambridge, Storbritannien
  • Nasser Laouali, University Paris-Saclay, University Paris-Sud, Villejuif, Frankrig
  • Giovanna Masala, Prevention and Clinical Networking, Italien
  • Peter M Nilsson, Lund University, Sverige
  • Kim Overvad
  • Salvatore Panico, Federico II University, Naples, Italy., Italien
  • Keren Papier, University of Oxford, Storbritannien
  • J Ramón Quirós, Public Health Directorate, Asturias, Spain., Spanien
  • Olov Rolandsson, Umeå University, Sverige
  • Daniel Redondo-Sánchez, Andalusian School of Public Health, Granada, Spain., Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Biosanitary Research Institute of Granada (Granada.ibs), Granada, Spain., Spanien
  • Fulvio Ricceri, Unit of Epidemiology, Regional Health Service ASL TO3, Grugliasco (TO), Turin, Italy., University of Turin, Italien
  • Matthias B Schulze, German Institute of Human Nutrition Potsdam-Rehbruecke, German Centre for Diabetes Research, Neuherberg, University of Potsdam, Tyskland
  • Annemieke M W Spijkerman, Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands., Holland
  • Anne Tjønneland, Danish Cancer Society Research Centre, Copenhagen, Denmark., Danmark
  • Tammy Y N Tong, University of Oxford, Storbritannien
  • Rosario Tumino, Cancer Registry and Histopathology Department, Azienda Sanitaria Provinciale (ASP) Ragusa, Italy., Italien
  • Elisabete Weiderpass, International Agency for Research on Cancer Lyon, France., Frankrig
  • John Danesh, Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK., University of Cambridge, Addenbrooke's Hospital, Storbritannien
  • Adam S Butterworth, University of Cambridge, Storbritannien
  • Elio Riboli, Imperial College London, Storbritannien
  • Nita G Forouhi, University of Cambridge, School of Clinical Medicine., Storbritannien
  • Nicholas J Wareham, University of Cambridge, School of Clinical Medicine., Storbritannien

OBJECTIVE: To investigate the association of plasma vitamin C and carotenoids, as indicators of fruit and vegetable intake, with the risk of type 2 diabetes.

DESIGN: Prospective case-cohort study.

SETTING: Populations from eight European countries.

PARTICIPANTS: 9754 participants with incident type 2 diabetes, and a subcohort of 13 662 individuals from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort of 340 234 participants: EPIC-InterAct case-cohort study.

MAIN OUTCOME MEASURE: Incident type 2 diabetes.

RESULTS: In a multivariable adjusted model, higher plasma vitamin C was associated with a lower risk of developing type 2 diabetes (hazard ratio per standard deviation 0.82, 95% confidence interval 0.76 to 0.89). A similar inverse association was shown for total carotenoids (hazard ratio per standard deviation 0.75, 0.68 to 0.82). A composite biomarker score (split into five equal groups), comprising vitamin C and individual carotenoids, was inversely associated with type 2 diabetes with hazard ratios 0.77, 0.66, 0.59, and 0.50 for groups 2-5 compared with group 1 (the lowest group). Self-reported median fruit and vegetable intake was 274 g/day, 396 g/day, and 508 g/day for participants in categories defined by groups 1, 3, and 5 of the composite biomarker score, respectively. One standard deviation difference in the composite biomarker score, equivalent to a 66 (95% confidence interval 61 to 71) g/day difference in total fruit and vegetable intake, was associated with a hazard ratio of 0.75 (0.67 to 0.83). This would be equivalent to an absolute risk reduction of 0.95 per 1000 person years of follow up if achieved across an entire population with the characteristics of the eight European countries included in this analysis.

CONCLUSIONS: These findings indicate an inverse association between plasma vitamin C, carotenoids, and their composite biomarker score, and incident type 2 diabetes in different European countries. These biomarkers are objective indicators of fruit and vegetable consumption, and suggest that diets rich in even modestly higher fruit and vegetable consumption could help to prevent development of type 2 diabetes.

OriginalsprogEngelsk
Artikelnummerm2194
TidsskriftB M J
Vol/bind370
Antal sider14
ISSN0959-8146
DOI
StatusUdgivet - jul. 2020

Bibliografisk note

© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. No commercial re-use. See rights and permissions. Published by BMJ.

Se relationer på Aarhus Universitet Citationsformater

ID: 192361455