Association of lectin pathway proteins with intra-abdominal Candida infection in high-risk surgical intensive-care unit patients. A prospective cohort study within the fungal infection network of Switzerland

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  • Michael Osthoff, Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; Department of Biomedicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland. Electronic address: michael.osthoff@usb.ch.
  • ,
  • Agnieszka Wojtowicz, Infectious Diseases Service, Department of Medicine, Lausanne University Hospital (CHUV), Rue du Bugnon 21, 1011 Lausanne, Switzerland.
  • ,
  • Frederic Tissot, Infectious Diseases Service, Department of Medicine, Lausanne University Hospital (CHUV), Rue du Bugnon 21, 1011 Lausanne, Switzerland.
  • ,
  • Clara Jørgensen
  • Steffen Thiel
  • Stephan Zimmerli, Department of Infectious Diseases, University Hospital, Inselspital, Freiburgstrasse 4, 3010 Bern, Switzerland.
  • ,
  • Oscar Marchetti, Infectious Diseases Service, Department of Medicine, Lausanne University Hospital (CHUV), Rue du Bugnon 21, 1011 Lausanne, Switzerland.
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  • Nina Khanna, Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; Department of Biomedicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.
  • ,
  • Pierre-Yves Bochud, Infectious Diseases Service, Department of Medicine, Lausanne University Hospital (CHUV), Rue du Bugnon 21, 1011 Lausanne, Switzerland.
  • ,
  • Marten Trendelenburg, Department of Biomedicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; Clinic for Internal Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.
  • ,
  • Fungal Infection Network of Switzerland (FUNGINOS)

OBJECTIVES: Human studies on the role of mannose-binding lectin (MBL) in patients with invasive candidiasis have yielded conflicting results. We investigated the influence of MBL and other lectin pathway proteins on Candida colonization and intra-abdominal candidiasis (IAC) in a cohort of high-risk patients.

METHODS: Prospective observational cohort study of 89 high-risk intensive-care unit (ICU) patients. Levels of lectin pathway proteins at study entry and six MBL2 single-nucleotide polymorphisms were analyzed by sandwich-type immunoassays and genotyping, respectively, and correlated with development of heavy Candida colonization (corrected colonization index (CCI) ≥0.4) and occurrence of IAC during a 4-week period.

RESULTS: Within 4 weeks after inclusion a CCI ≥0.4 and IAC was observed in 47% and 38% of patients respectively. Neither serum levels of MBL, ficolin-1, -2, -3, MASP-2 or collectin liver 1 nor MBL2 genotypes were associated with a CCI ≥0.4. Similarly, none of the analyzed proteins was found to be associated with IAC with the exception of lower MBL levels (HR 0.74, p = 0.02) at study entry. However, there was no association of MBL deficiency (<0.5 μg/ml), MBL2 haplo- or genotypes with IAC.

CONCLUSION: Lectin pathway protein levels and MBL2 genotype investigated in this study were not associated with heavy Candida colonization or IAC in a cohort of high-risk ICU patients.

OriginalsprogEngelsk
TidsskriftJournal of Infection
Vol/bind72
Nummer3
Sider (fra-til)377-85
Antal sider9
ISSN0163-4453
DOI
StatusUdgivet - mar. 2016

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