Association of Cognitive Impairment with Combinations of Vitamin B12-Related Parameters

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  • Klinisk Biokemisk Afdeling, NBG
  • Molekylærbiologisk Institut
  • Klinisk Biokemisk Afdeling NBG
BACKGROUND: Low vitamin B(12) concentrations have been associated with higher risks of cognitive impairment, but whether these associations are causal is uncertain. The associations of cognitive impairment with combinations of vitamin B(12), holotranscobalamin, methylmalonic acid, and total homocysteine, and with the vitamin B(12) transport proteins transcobalamin and haptocorrin, have not been previously studied. METHODS: We performed a population-based cross-sectional study of 839 people 75 years old or older. We examined the association of cognitive function as measured by mini-mental state examination scores, with markers of vitamin B(12) status. Spearman correlations as well as multivariate-adjusted odds ratios and 95% CIs for cognitive impairment were calculated for extreme thirds of serum concentrations of vitamin B(12), holotranscobalamin, methylmalonic acid, total homocysteine, combination of these markers in a wellness score, heaptocorrin, and transcobalamin for all data and with B(12) analogs in a nested case-control study. RESULTS: Cognitive impairment was significantly associated with low vitamin B(12) [odds ratio 2.3 (95% CI 1.2-4.5)]; low holotranscobalamin [4.1 (2.0-8.7)], high methylmalonic acid [3.5 (1.8-7.1)], high homocysteine [4.8 (2.3-10.0)] and low wellness score [5.1 (2.61-10.46)]. After correction for relevant covariates, cognitive impairment remained significantly associated with high homocysteine [4.85 (2.24-10.53)] and with a low wellness score [5.60 (2.61-12.01)] but not with transcobalamin, haptocorrin, or analogs on haptocorrin. CONCLUSIONS: Cognitive impairment was associated with the combined effects of the 4 biomarkers of vitamin B(12) deficiency when included in a wellness score but was not associated with binding proteins or analogs on haptocorrin.
OriginalsprogEngelsk
TidsskriftClinical Chemistry (Chicago)
Vol/bind57
Nummer10
Antal sider8
ISSN1056-599X
DOI
StatusUdgivet - 11 aug. 2011

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