Association of beta-blockers and first-registered heart rhythm in out-of-hospital cardiac arrest: real-world data from population-based cohorts across two European countries

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Association of beta-blockers and first-registered heart rhythm in out-of-hospital cardiac arrest : real-world data from population-based cohorts across two European countries. / Barcella, Carlo A.; Eroglu, Talip E.; Hulleman, Michiel; Granfeldt, Asger; Souverein, Patrick C.; Mohr, Grimur H.; Koster, Rudolph W.; Wissenberg, Mads; de Boer, Anthonius; Torp-Pedersen, Christian; Folke, Fredrik; Blom, Marieke T.; Gislason, Gunnar H.; Tan, Hanno L.; ESCAPE-NET Investigators.

I: Europace, Bind 22, Nr. 8, 08.2020, s. 1206-1215.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Barcella, CA, Eroglu, TE, Hulleman, M, Granfeldt, A, Souverein, PC, Mohr, GH, Koster, RW, Wissenberg, M, de Boer, A, Torp-Pedersen, C, Folke, F, Blom, MT, Gislason, GH, Tan, HL & ESCAPE-NET Investigators 2020, 'Association of beta-blockers and first-registered heart rhythm in out-of-hospital cardiac arrest: real-world data from population-based cohorts across two European countries', Europace, bind 22, nr. 8, s. 1206-1215. https://doi.org/10.1093/europace/euaa124

APA

Barcella, C. A., Eroglu, T. E., Hulleman, M., Granfeldt, A., Souverein, P. C., Mohr, G. H., Koster, R. W., Wissenberg, M., de Boer, A., Torp-Pedersen, C., Folke, F., Blom, M. T., Gislason, G. H., Tan, H. L., & ESCAPE-NET Investigators (2020). Association of beta-blockers and first-registered heart rhythm in out-of-hospital cardiac arrest: real-world data from population-based cohorts across two European countries. Europace, 22(8), 1206-1215. https://doi.org/10.1093/europace/euaa124

CBE

Barcella CA, Eroglu TE, Hulleman M, Granfeldt A, Souverein PC, Mohr GH, Koster RW, Wissenberg M, de Boer A, Torp-Pedersen C, Folke F, Blom MT, Gislason GH, Tan HL, ESCAPE-NET Investigators. 2020. Association of beta-blockers and first-registered heart rhythm in out-of-hospital cardiac arrest: real-world data from population-based cohorts across two European countries. Europace. 22(8):1206-1215. https://doi.org/10.1093/europace/euaa124

MLA

Vancouver

Author

Barcella, Carlo A. ; Eroglu, Talip E. ; Hulleman, Michiel ; Granfeldt, Asger ; Souverein, Patrick C. ; Mohr, Grimur H. ; Koster, Rudolph W. ; Wissenberg, Mads ; de Boer, Anthonius ; Torp-Pedersen, Christian ; Folke, Fredrik ; Blom, Marieke T. ; Gislason, Gunnar H. ; Tan, Hanno L. ; ESCAPE-NET Investigators. / Association of beta-blockers and first-registered heart rhythm in out-of-hospital cardiac arrest : real-world data from population-based cohorts across two European countries. I: Europace. 2020 ; Bind 22, Nr. 8. s. 1206-1215.

Bibtex

@article{f0cb40348c724d68a2b9eddbbacd5992,
title = "Association of beta-blockers and first-registered heart rhythm in out-of-hospital cardiac arrest: real-world data from population-based cohorts across two European countries",
abstract = "AIMS: Conflicting results have been reported regarding the effect of beta-blockers on first-registered heart rhythm in out-of-hospital cardiac arrest (OHCA). We aimed to establish whether the use of beta-blockers influences first-registered rhythm in OHCA. METHODS AND RESULTS: We included patients with OHCA of presumed cardiac cause from two large independent OHCA-registries from Denmark and the Netherlands. Beta-blocker use was defined as exposure to either non-selective beta-blockers, β1-selective beta-blockers, or α-β-dual-receptor blockers within 90 days prior to OHCA. We calculated odds ratios (ORs) for the association of beta-blockers with first-registered heart rhythm using multivariable logistic regression. We identified 23 834 OHCA-patients in Denmark and 1584 in the Netherlands: 7022 (29.5%) and 519 (32.8%) were treated with beta-blockers, respectively. Use of non-selective beta-blockers, but not β1-selective blockers, was more often associated with non-shockable rhythm than no use of beta-blockers [Denmark: OR 1.93, 95% confidence interval (CI) 1.48-2.52; the Netherlands: OR 2.52, 95% CI 1.15-5.49]. Non-selective beta-blocker use was associated with higher proportion of pulseless electrical activity (PEA) than of shockable rhythm (OR 2.38, 95% CI 1.01-5.65); the association with asystole was of similar magnitude, although not statistically significant compared with shockable rhythm (OR 2.34, 95% CI 0.89-6.18; data on PEA and asystole were only available in the Netherlands). Use of α-β-dual-receptor blockers was significantly associated with non-shockable rhythm in Denmark (OR 1.21; 95% CI 1.03-1.42) and not significantly in the Netherlands (OR 1.37; 95% CI 0.61-3.07). CONCLUSION: Non-selective beta-blockers, but not β1-selective beta-blockers, are associated with non-shockable rhythm in OHCA.",
keywords = "Asystole, Beta-blockers, ESCAPE-NET, First-registered heart rhythm, Non-shockable heart rhythm, Out-of-hospital cardiac arrest, Pulseless electrical activity",
author = "Barcella, {Carlo A.} and Eroglu, {Talip E.} and Michiel Hulleman and Asger Granfeldt and Souverein, {Patrick C.} and Mohr, {Grimur H.} and Koster, {Rudolph W.} and Mads Wissenberg and {de Boer}, Anthonius and Christian Torp-Pedersen and Fredrik Folke and Blom, {Marieke T.} and Gislason, {Gunnar H.} and Tan, {Hanno L.} and {ESCAPE-NET Investigators}",
year = "2020",
month = aug,
doi = "10.1093/europace/euaa124",
language = "English",
volume = "22",
pages = "1206--1215",
journal = "Europace",
issn = "1099-5129",
publisher = "Oxford University Press",
number = "8",

}

RIS

TY - JOUR

T1 - Association of beta-blockers and first-registered heart rhythm in out-of-hospital cardiac arrest

T2 - real-world data from population-based cohorts across two European countries

AU - Barcella, Carlo A.

AU - Eroglu, Talip E.

AU - Hulleman, Michiel

AU - Granfeldt, Asger

AU - Souverein, Patrick C.

AU - Mohr, Grimur H.

AU - Koster, Rudolph W.

AU - Wissenberg, Mads

AU - de Boer, Anthonius

AU - Torp-Pedersen, Christian

AU - Folke, Fredrik

AU - Blom, Marieke T.

AU - Gislason, Gunnar H.

AU - Tan, Hanno L.

AU - ESCAPE-NET Investigators

PY - 2020/8

Y1 - 2020/8

N2 - AIMS: Conflicting results have been reported regarding the effect of beta-blockers on first-registered heart rhythm in out-of-hospital cardiac arrest (OHCA). We aimed to establish whether the use of beta-blockers influences first-registered rhythm in OHCA. METHODS AND RESULTS: We included patients with OHCA of presumed cardiac cause from two large independent OHCA-registries from Denmark and the Netherlands. Beta-blocker use was defined as exposure to either non-selective beta-blockers, β1-selective beta-blockers, or α-β-dual-receptor blockers within 90 days prior to OHCA. We calculated odds ratios (ORs) for the association of beta-blockers with first-registered heart rhythm using multivariable logistic regression. We identified 23 834 OHCA-patients in Denmark and 1584 in the Netherlands: 7022 (29.5%) and 519 (32.8%) were treated with beta-blockers, respectively. Use of non-selective beta-blockers, but not β1-selective blockers, was more often associated with non-shockable rhythm than no use of beta-blockers [Denmark: OR 1.93, 95% confidence interval (CI) 1.48-2.52; the Netherlands: OR 2.52, 95% CI 1.15-5.49]. Non-selective beta-blocker use was associated with higher proportion of pulseless electrical activity (PEA) than of shockable rhythm (OR 2.38, 95% CI 1.01-5.65); the association with asystole was of similar magnitude, although not statistically significant compared with shockable rhythm (OR 2.34, 95% CI 0.89-6.18; data on PEA and asystole were only available in the Netherlands). Use of α-β-dual-receptor blockers was significantly associated with non-shockable rhythm in Denmark (OR 1.21; 95% CI 1.03-1.42) and not significantly in the Netherlands (OR 1.37; 95% CI 0.61-3.07). CONCLUSION: Non-selective beta-blockers, but not β1-selective beta-blockers, are associated with non-shockable rhythm in OHCA.

AB - AIMS: Conflicting results have been reported regarding the effect of beta-blockers on first-registered heart rhythm in out-of-hospital cardiac arrest (OHCA). We aimed to establish whether the use of beta-blockers influences first-registered rhythm in OHCA. METHODS AND RESULTS: We included patients with OHCA of presumed cardiac cause from two large independent OHCA-registries from Denmark and the Netherlands. Beta-blocker use was defined as exposure to either non-selective beta-blockers, β1-selective beta-blockers, or α-β-dual-receptor blockers within 90 days prior to OHCA. We calculated odds ratios (ORs) for the association of beta-blockers with first-registered heart rhythm using multivariable logistic regression. We identified 23 834 OHCA-patients in Denmark and 1584 in the Netherlands: 7022 (29.5%) and 519 (32.8%) were treated with beta-blockers, respectively. Use of non-selective beta-blockers, but not β1-selective blockers, was more often associated with non-shockable rhythm than no use of beta-blockers [Denmark: OR 1.93, 95% confidence interval (CI) 1.48-2.52; the Netherlands: OR 2.52, 95% CI 1.15-5.49]. Non-selective beta-blocker use was associated with higher proportion of pulseless electrical activity (PEA) than of shockable rhythm (OR 2.38, 95% CI 1.01-5.65); the association with asystole was of similar magnitude, although not statistically significant compared with shockable rhythm (OR 2.34, 95% CI 0.89-6.18; data on PEA and asystole were only available in the Netherlands). Use of α-β-dual-receptor blockers was significantly associated with non-shockable rhythm in Denmark (OR 1.21; 95% CI 1.03-1.42) and not significantly in the Netherlands (OR 1.37; 95% CI 0.61-3.07). CONCLUSION: Non-selective beta-blockers, but not β1-selective beta-blockers, are associated with non-shockable rhythm in OHCA.

KW - Asystole

KW - Beta-blockers

KW - ESCAPE-NET

KW - First-registered heart rhythm

KW - Non-shockable heart rhythm

KW - Out-of-hospital cardiac arrest

KW - Pulseless electrical activity

UR - http://www.scopus.com/inward/record.url?scp=85089128042&partnerID=8YFLogxK

U2 - 10.1093/europace/euaa124

DO - 10.1093/europace/euaa124

M3 - Journal article

C2 - 32594166

AN - SCOPUS:85089128042

VL - 22

SP - 1206

EP - 1215

JO - Europace

JF - Europace

SN - 1099-5129

IS - 8

ER -