Association between women's age and stage, morphology, and implantation of the competent blastocyst: a multicenter cohort study

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • Maria Buhl Borgstrøm, Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
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  • Marie Louise Grøndahl, Department of Nuclear Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark; Department of Oncology, Copenhagen University Hospital Herlev, Herlev, Denmark.
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  • Tobias Wirenfeldt Klausen, Department of Nuclear Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark; Department of Oncology, Copenhagen University Hospital Herlev, Herlev, Denmark.
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  • Anne Kjærgaard Danielsen, Department of Nuclear Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark; Department of Oncology, Copenhagen University Hospital Herlev, Herlev, Denmark.
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  • Thordis Thomsen, Department of Nuclear Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark; Department of Oncology, Copenhagen University Hospital Herlev, Herlev, Denmark.
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  • Anette Gabrielsen, Obstetrics and Gynaecology Department, Regional Hospital Horsens, Horsens, Denmark
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  • Anne Zedeler, Department of Ambulatory Surgery, Hvidovre Hospital, Copenhagen University Hospital, Kettegårdsalle 30, 2650 Hvidovre, Copenhagen, Denmark.
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  • Betina Boel Povlsen
  • Christina Hnida, Aalborg Psychiatric University Hospital, Aalborg, Denmark Department of Clinical Medicine, Aalborg University Hospital, Aalborg, Denmark.
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  • Gitte Juul Almind, Copenhagen Fertility Center
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  • Jens Fedder, Syddansk Universitet
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  • John Kirk, Maigaard Fertility Clinic, Jens Baggesensvej 88 H, 8200 Aarhus N, Denmark.
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  • Johnny Hindkjær, Aagaard Fertility Clinic
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  • Josephine G Lemmen, Vitanova Fertility Center
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  • Karsten Petersen, VivaNeo Ciconia Fertility Clinic, Højbjerg Bibliotek
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  • Katrine Haahr, Stork IVF Clinic
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  • Morten Rønn Petersen, *Department of Gynecology and Obstetrics, Copenhagen University Hospital Rigshospitalet, Copenhagen; and †Department of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark., The Fertility Clinic, The Danish Multiple Sclerosis Registry, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark/Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
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  • Steen Laursen, The Fertility Clinic IVF-syd
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  • Thomas Høst Hansen, The Fertility Clinic, Department of Anesthesiology, Zealand University Hospital Koege, Koege, Denmark.
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  • Ulla Breth Knudsen
  • Ursula Bentin-Ley, The Danish Fertility Clinic
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  • Thomas Larsen, Danish Medical Data Center, Vallensbæk Kommune
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  • Ulrik Schiøler Kesmodel

OBJECTIVE: To study if the age of women undergoing assisted reproductive technology treatment associates with stage, morphology, and implantation of the competent blastocyst.

DESIGN: Multicenter historical cohort study based on exposure (age) and outcome data (blastocyst stage and morphology and initial human chorionic gonadotrophin [hCG] rise) from women undergoing single blastocyst transfer resulting in singleton pregnancy/birth.

SETTING: Sixteen private and university-based facilities.

PATIENT(S): In this study, 7,246 women who, between 2014 and 2018, underwent controlled ovarian stimulation (COS) or frozen-thawed embryo transfer (FET) with a single blastocyst transfer resulting in singleton pregnancy were identified. Linking data to the Danish Medical Birth Registry resulted in a total of 4,842 women with a live birth being included.

INTERVENTION(S): None.

MAIN OUTCOME MEASURE(S): The competent blastocyst development stage (1-6), inner cell mass (A, B, C), trophectoderm (A, B, C), and initial serum hCG value.

RESULT(S): Adjusted analysis of age and stage in COS treatments showed that for every 1-year increase in age there was a 5% reduced probability of the competent blastocyst assessed as being in a high stage at transfer. Comparison between hCG values in women 18-24 years and 25-29 years in both COS and FET showed significantly lower levels in the youngest women.

CONCLUSION(S): The initial hCG rise was influenced by the age of the woman, with an identical pattern for hCG values in COS and FET treatments. In COS, the competent blastocyst had a reduced stage with increasing women's age.

OriginalsprogEngelsk
TidsskriftFertility and Sterility
Vol/bind115
Nummer3
Sider (fra-til)646-654
ISSN0015-0282
DOI
StatusUdgivet - mar. 2021

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