Association between vitamin K1 intake and mortality in the Danish Diet, Cancer, and Health cohort

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

  • Claire R Palmer, Edith Cowan Univ, Edith Cowan University, Sch Med & Hlth Sci, Australien
  • Jamie W Bellinge, University of Western Australia, School of medicine and pharmacology, Perth, Department of Cardiology, Royal Perth Hospital, Perth, Australien
  • Frederik Dalgaard, Herlev and Gentofte University Hospital, Danmark
  • Marc Sim, Edith Cowan Univ, Edith Cowan University, Sch Med & Hlth Sci, University of Western Australia, School of medicine and pharmacology, Perth, Australien
  • Kevin Murray, School of Population and Global Health, University of Western Australia, Perth, WA, Australia., Australien
  • Emma Connolly, Edith Cowan Univ, Edith Cowan University, Sch Med & Hlth Sci, Australien
  • Lauren C Blekkenhorst, Edith Cowan Univ, Edith Cowan University, Sch Med & Hlth Sci, University of Western Australia, School of medicine and pharmacology, Perth, Australien
  • Catherine P Bondonno, Edith Cowan Univ, Edith Cowan University, Sch Med & Hlth Sci, University of Western Australia, School of medicine and pharmacology, Perth, Australien
  • Kevin D Croft, School of Biomedical Sciences, University of Western Australia, Royal Perth Hospital, Perth, Western Australia, Australia., Australien
  • Gunnar Gislason, Herlev and Gentofte University Hospital, The National Institute of Public Health, University of Southern Denmark, Odense, The Danish Heart Foundation, Danmark
  • Anne Tjønneland, The Danish Cancer Society Research Centre, Copenhagen, Denmark; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Danmark
  • Kim Overvad
  • Carl Schultz, Department of Cardiology, Royal Perth Hospital, Perth, University of Western Australia, School of medicine and pharmacology, Perth, Australien
  • Joshua R Lewis, Edith Cowan Univ, Edith Cowan University, Sch Med & Hlth Sci, University of Western Australia, School of medicine and pharmacology, Perth, Centre for Kidney Research, Children's Hospital at Westmead, School of Public Health, Sydney Medical School, The University of Sydney, Sydney, Australia., Australien
  • Jonathan M Hodgson, Edith Cowan Univ, Edith Cowan University, Sch Med & Hlth Sci, University of Western Australia, School of medicine and pharmacology, Perth, Australien
  • Nicola P Bondonno, Edith Cowan Univ, Edith Cowan University, Sch Med & Hlth Sci, School of Biomedical Sciences, University of Western Australia, Royal Perth Hospital, Perth, Western Australia, Australia., Australien

Reported associations between vitamin K-1 and both all-cause and cause-specific mortality are conflicting. The 56,048 participants from the Danish Diet, Cancer, and Health prospective cohort study, with a median [IQR] age of 56 [52-60] years at entry and of whom 47.6% male, were followed for 23 years, with 14,083 reported deaths. Of these, 5015 deaths were CVD-related, and 6342 deaths were cancer-related. Intake of vitamin K-1 (phylloquinone) was estimated from a food-frequency questionnaire (FFQ), and its relationship with mortality outcomes was investigated using Cox proportional hazards models. A moderate to high (87-192 mu g/d) intake of vitamin K-1 was associated with a lower risk of all-cause [HR (95%CI) for quintile 5 vs quintile 1: 0.76 (0.72, 0.79)], cardiovascular disease (CVD)-related [quintile 5 vs quintile 1: 0.72 (0.66, 0.79)], and cancer-related mortality [quintile 5 vs quintile 1: 0.80 (0.75, 0.86)], after adjusting for demographic and lifestyle confounders. The association between vitamin K-1 intake and cardiovascular disease-related mortality was present in all subpopulations (categorised according to sex, smoking status, diabetes status, and hypertension status), while the association with cancer-related mortality was only present in current/former smokers (p for interaction = 0.002). These findings suggest that promoting adequate intakes of foods rich in vitamin K-1 may help to reduce all-cause, CVD-related, and cancer-related mortality at the population level.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Epidemiology
Vol/bind36
Nummer10
Sider (fra-til)1005-1014
Antal sider10
ISSN0393-2990
DOI
StatusUdgivet - okt. 2021

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© 2021. The Author(s).

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