Assisted reproductive technology treatment in women with severe eating disorders: a national cohort study

Maria Assens; Ninna H Ebdrup; Anja Pinborg; Lone Schmidt; Charlotte O Hougaard; Ida Hageman

doi:10.1111/aogs.12727

Assisted reproductive technology treatment in women with severe eating disorders: a national cohort study

Maria Assens, Ninna H Ebdrup, Anja Pinborg, Lone Schmidt, Charlotte O Hougaard, Ida Hageman

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

9 Citationer (Scopus)

Abstract

INTRODUCTION: This national retrospective cohort study investigates the prevalence of women with severe eating disorders in assisted reproductive technology (ART) treatment compared with an age-matched background population without ART treatment. It assesses the frequency distribution of the first and last eating disorder diagnosis before, during, and after ART treatment, and evaluates differences in obstetric outcomes between women with and without a severe eating disorder.

MATERIAL AND METHODS: Hospital-diagnosed eating disorders among 42,915 women in the Danish National ART cohort (DANAC), registered during 1994-2009 in the mandatory Psychiatric Central Research Register, were compared with a non-eating disorder ART cohort of 42,644 women and an age-matched background population of 215,290 women without a history of ART treatment for the main outcome measures prevalence of eating disorders, frequency distribution of diagnoses before/during/after ART treatment, as well as ART treatment and obstetric outcomes.

RESULTS: In the ART cohort, 271 women (0.63%) had an eating disorder diagnosis compared with 0.73% in the background population (p = 0.025). The prevalence of ovulatory disorder was significantly higher in women with a severe eating disorder compared with the ART cohort without eating disorders. Obstetric outcomes were similar in ART-treated women with and without an eating disorder.

CONCLUSION: Women with severe eating disorders were identified in the ART cohort, although significantly less often than in the age-matched background population. Women with severe eating disorders suffered more often from anovulatory infertility than the ART comparison cohort without this disease. Obstetric outcomes appeared reassuring in the ART cohort with eating disorders.

Originalsprog	Engelsk
Tidsskrift	Acta Obstetricia et Gynecologica Scandinavica
Vol/bind	94
Nummer	11
Sider (fra-til)	1254-61
Antal sider	8
ISSN	0001-6349
DOI	https://doi.org/10.1111/aogs.12727
Status	Udgivet - nov. 2015

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10.1111/aogs.12727

Citationsformater

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title = "Assisted reproductive technology treatment in women with severe eating disorders: a national cohort study",

abstract = "INTRODUCTION: This national retrospective cohort study investigates the prevalence of women with severe eating disorders in assisted reproductive technology (ART) treatment compared with an age-matched background population without ART treatment. It assesses the frequency distribution of the first and last eating disorder diagnosis before, during, and after ART treatment, and evaluates differences in obstetric outcomes between women with and without a severe eating disorder.MATERIAL AND METHODS: Hospital-diagnosed eating disorders among 42,915 women in the Danish National ART cohort (DANAC), registered during 1994-2009 in the mandatory Psychiatric Central Research Register, were compared with a non-eating disorder ART cohort of 42,644 women and an age-matched background population of 215,290 women without a history of ART treatment for the main outcome measures prevalence of eating disorders, frequency distribution of diagnoses before/during/after ART treatment, as well as ART treatment and obstetric outcomes.RESULTS: In the ART cohort, 271 women (0.63%) had an eating disorder diagnosis compared with 0.73% in the background population (p = 0.025). The prevalence of ovulatory disorder was significantly higher in women with a severe eating disorder compared with the ART cohort without eating disorders. Obstetric outcomes were similar in ART-treated women with and without an eating disorder.CONCLUSION: Women with severe eating disorders were identified in the ART cohort, although significantly less often than in the age-matched background population. Women with severe eating disorders suffered more often from anovulatory infertility than the ART comparison cohort without this disease. Obstetric outcomes appeared reassuring in the ART cohort with eating disorders.",

keywords = "Adult, Anovulation/complications, Case-Control Studies, Cohort Studies, Denmark/epidemiology, Feeding and Eating Disorders/epidemiology, Female, Humans, Infertility, Female/etiology, Pregnancy, Pregnancy Outcome, Registries, Reproductive Techniques, Assisted, Retrospective Studies, Severity of Illness Index",

author = "Maria Assens and Ebdrup, {Ninna H} and Anja Pinborg and Lone Schmidt and Hougaard, {Charlotte O} and Ida Hageman",

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Assisted reproductive technology treatment in women with severe eating disorders: a national cohort study. / Assens, Maria; Ebdrup, Ninna H; Pinborg, Anja et al.
I: Acta Obstetricia et Gynecologica Scandinavica, Bind 94, Nr. 11, 11.2015, s. 1254-61.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - Assisted reproductive technology treatment in women with severe eating disorders

T2 - a national cohort study

AU - Assens, Maria

AU - Ebdrup, Ninna H

AU - Pinborg, Anja

AU - Schmidt, Lone

AU - Hougaard, Charlotte O

AU - Hageman, Ida

PY - 2015/11

Y1 - 2015/11

N2 - INTRODUCTION: This national retrospective cohort study investigates the prevalence of women with severe eating disorders in assisted reproductive technology (ART) treatment compared with an age-matched background population without ART treatment. It assesses the frequency distribution of the first and last eating disorder diagnosis before, during, and after ART treatment, and evaluates differences in obstetric outcomes between women with and without a severe eating disorder.MATERIAL AND METHODS: Hospital-diagnosed eating disorders among 42,915 women in the Danish National ART cohort (DANAC), registered during 1994-2009 in the mandatory Psychiatric Central Research Register, were compared with a non-eating disorder ART cohort of 42,644 women and an age-matched background population of 215,290 women without a history of ART treatment for the main outcome measures prevalence of eating disorders, frequency distribution of diagnoses before/during/after ART treatment, as well as ART treatment and obstetric outcomes.RESULTS: In the ART cohort, 271 women (0.63%) had an eating disorder diagnosis compared with 0.73% in the background population (p = 0.025). The prevalence of ovulatory disorder was significantly higher in women with a severe eating disorder compared with the ART cohort without eating disorders. Obstetric outcomes were similar in ART-treated women with and without an eating disorder.CONCLUSION: Women with severe eating disorders were identified in the ART cohort, although significantly less often than in the age-matched background population. Women with severe eating disorders suffered more often from anovulatory infertility than the ART comparison cohort without this disease. Obstetric outcomes appeared reassuring in the ART cohort with eating disorders.

AB - INTRODUCTION: This national retrospective cohort study investigates the prevalence of women with severe eating disorders in assisted reproductive technology (ART) treatment compared with an age-matched background population without ART treatment. It assesses the frequency distribution of the first and last eating disorder diagnosis before, during, and after ART treatment, and evaluates differences in obstetric outcomes between women with and without a severe eating disorder.MATERIAL AND METHODS: Hospital-diagnosed eating disorders among 42,915 women in the Danish National ART cohort (DANAC), registered during 1994-2009 in the mandatory Psychiatric Central Research Register, were compared with a non-eating disorder ART cohort of 42,644 women and an age-matched background population of 215,290 women without a history of ART treatment for the main outcome measures prevalence of eating disorders, frequency distribution of diagnoses before/during/after ART treatment, as well as ART treatment and obstetric outcomes.RESULTS: In the ART cohort, 271 women (0.63%) had an eating disorder diagnosis compared with 0.73% in the background population (p = 0.025). The prevalence of ovulatory disorder was significantly higher in women with a severe eating disorder compared with the ART cohort without eating disorders. Obstetric outcomes were similar in ART-treated women with and without an eating disorder.CONCLUSION: Women with severe eating disorders were identified in the ART cohort, although significantly less often than in the age-matched background population. Women with severe eating disorders suffered more often from anovulatory infertility than the ART comparison cohort without this disease. Obstetric outcomes appeared reassuring in the ART cohort with eating disorders.

KW - Adult

KW - Anovulation/complications

KW - Case-Control Studies

KW - Cohort Studies

KW - Denmark/epidemiology

KW - Feeding and Eating Disorders/epidemiology

KW - Female

KW - Humans

KW - Infertility, Female/etiology

KW - Pregnancy

KW - Pregnancy Outcome

KW - Registries

KW - Reproductive Techniques, Assisted

KW - Retrospective Studies

KW - Severity of Illness Index

U2 - 10.1111/aogs.12727

DO - 10.1111/aogs.12727

M3 - Journal article

C2 - 26249555

SN - 0001-6349

VL - 94

SP - 1254

EP - 1261

JO - Acta Obstetricia et Gynecologica Scandinavica

JF - Acta Obstetricia et Gynecologica Scandinavica

IS - 11

ER -

Assisted reproductive technology treatment in women with severe eating disorders: a national cohort study

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