Assessment of myometrial invasion in endometrial cancer using three-dimensional ultrasound and magnetic resonance imaging

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Assessment of myometrial invasion in endometrial cancer using three-dimensional ultrasound and magnetic resonance imaging. / Christensen, Julie W; Dueholm, Margit; Hansen, Estrid S; Marinovskij, Edward; Lundorf, Erik; Ørtoft, Gitte.

I: Acta Obstetrica et Gynecologica, 20.10.2015.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{2c164159bf594f34b245d33fd5182352,
title = "Assessment of myometrial invasion in endometrial cancer using three-dimensional ultrasound and magnetic resonance imaging",
abstract = "INTRODUCTION: Preoperative knowledge of myometrial invasion in endometrial cancer is important for surgical planning. This study aimed to assess the diagnostic efficiency of two-dimensional (2D) and three-dimensional (3D) transvaginal ultrasonography (TVS) with and without saline infusion (SIS) and magnetic resonance imaging (MRI) for assessment of myometrial invasion in endometrial cancer.MATERIAL AND METHODS: 110 women with atypical endometrial hyperplasia or endometrial adenocarcinoma underwent preoperative 2D- and 3D-TVS with and without SIS and MRI. Offline 3D-TVS measurement was performed of minimal tumor-free margin in relation to myometrial thickness expressed as deep (≥ 50{\%}) myometrial invasion and subjective impression of cervix involvement and also quality of images were evaluated. Diagnostic efficiencies were calculated for myometrial and cervical involvement for each method. The pathologist's final diagnosis served as the reference standard.RESULTS: For myometrial involvement, MRI showed greater accuracy than 3D-TVS and 2D-TVS (83{\%}, 71{\%} and 75{\%}, respectively). The efficiency of 3D-TVS was not superior to 2D-TVS and did not improve with SIS. The sensitivities of 2D-TVS and 3D-TVS were similar to that of MRI, and the efficiency of 3D-TVS improved when volumes of inadequate quality (39{\%}) were excluded. For evaluating cervical involvement, the accuracy of 3D-TVS was 85{\%}, comparable to the results of 2D-TVS (80{\%}) and MRI (85{\%}). The results did not improve when saline was added.CONCLUSION: 3D-TVS or 3D-SIS had no higher efficiency than 2D-TVS or MRI for assessment of myometrial invasion in endometrial cancer. 3D-TVS assessment without 2D-TVS was impeded by difficulties in obtaining 3D-TVS volumes of sufficient quality. This article is protected by copyright. All rights reserved.",
author = "Christensen, {Julie W} and Margit Dueholm and Hansen, {Estrid S} and Edward Marinovskij and Erik Lundorf and Gitte {\O}rtoft",
note = "This article is protected by copyright. All rights reserved.",
year = "2015",
month = "10",
day = "20",
doi = "10.1111/aogs.12806",
language = "English",
journal = "Acta Obstetrica et Gynecologica",
issn = "0001-6349",
publisher = "GrupoSaned",

}

RIS

TY - JOUR

T1 - Assessment of myometrial invasion in endometrial cancer using three-dimensional ultrasound and magnetic resonance imaging

AU - Christensen, Julie W

AU - Dueholm, Margit

AU - Hansen, Estrid S

AU - Marinovskij, Edward

AU - Lundorf, Erik

AU - Ørtoft, Gitte

N1 - This article is protected by copyright. All rights reserved.

PY - 2015/10/20

Y1 - 2015/10/20

N2 - INTRODUCTION: Preoperative knowledge of myometrial invasion in endometrial cancer is important for surgical planning. This study aimed to assess the diagnostic efficiency of two-dimensional (2D) and three-dimensional (3D) transvaginal ultrasonography (TVS) with and without saline infusion (SIS) and magnetic resonance imaging (MRI) for assessment of myometrial invasion in endometrial cancer.MATERIAL AND METHODS: 110 women with atypical endometrial hyperplasia or endometrial adenocarcinoma underwent preoperative 2D- and 3D-TVS with and without SIS and MRI. Offline 3D-TVS measurement was performed of minimal tumor-free margin in relation to myometrial thickness expressed as deep (≥ 50%) myometrial invasion and subjective impression of cervix involvement and also quality of images were evaluated. Diagnostic efficiencies were calculated for myometrial and cervical involvement for each method. The pathologist's final diagnosis served as the reference standard.RESULTS: For myometrial involvement, MRI showed greater accuracy than 3D-TVS and 2D-TVS (83%, 71% and 75%, respectively). The efficiency of 3D-TVS was not superior to 2D-TVS and did not improve with SIS. The sensitivities of 2D-TVS and 3D-TVS were similar to that of MRI, and the efficiency of 3D-TVS improved when volumes of inadequate quality (39%) were excluded. For evaluating cervical involvement, the accuracy of 3D-TVS was 85%, comparable to the results of 2D-TVS (80%) and MRI (85%). The results did not improve when saline was added.CONCLUSION: 3D-TVS or 3D-SIS had no higher efficiency than 2D-TVS or MRI for assessment of myometrial invasion in endometrial cancer. 3D-TVS assessment without 2D-TVS was impeded by difficulties in obtaining 3D-TVS volumes of sufficient quality. This article is protected by copyright. All rights reserved.

AB - INTRODUCTION: Preoperative knowledge of myometrial invasion in endometrial cancer is important for surgical planning. This study aimed to assess the diagnostic efficiency of two-dimensional (2D) and three-dimensional (3D) transvaginal ultrasonography (TVS) with and without saline infusion (SIS) and magnetic resonance imaging (MRI) for assessment of myometrial invasion in endometrial cancer.MATERIAL AND METHODS: 110 women with atypical endometrial hyperplasia or endometrial adenocarcinoma underwent preoperative 2D- and 3D-TVS with and without SIS and MRI. Offline 3D-TVS measurement was performed of minimal tumor-free margin in relation to myometrial thickness expressed as deep (≥ 50%) myometrial invasion and subjective impression of cervix involvement and also quality of images were evaluated. Diagnostic efficiencies were calculated for myometrial and cervical involvement for each method. The pathologist's final diagnosis served as the reference standard.RESULTS: For myometrial involvement, MRI showed greater accuracy than 3D-TVS and 2D-TVS (83%, 71% and 75%, respectively). The efficiency of 3D-TVS was not superior to 2D-TVS and did not improve with SIS. The sensitivities of 2D-TVS and 3D-TVS were similar to that of MRI, and the efficiency of 3D-TVS improved when volumes of inadequate quality (39%) were excluded. For evaluating cervical involvement, the accuracy of 3D-TVS was 85%, comparable to the results of 2D-TVS (80%) and MRI (85%). The results did not improve when saline was added.CONCLUSION: 3D-TVS or 3D-SIS had no higher efficiency than 2D-TVS or MRI for assessment of myometrial invasion in endometrial cancer. 3D-TVS assessment without 2D-TVS was impeded by difficulties in obtaining 3D-TVS volumes of sufficient quality. This article is protected by copyright. All rights reserved.

U2 - 10.1111/aogs.12806

DO - 10.1111/aogs.12806

M3 - Journal article

JO - Acta Obstetrica et Gynecologica

JF - Acta Obstetrica et Gynecologica

SN - 0001-6349

ER -