Artichoke compound cynarin differentially affects the survival, growth and stress response of normal, immortalized and cancerous human cells

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  • Ceren Gezer, 1Department of Nutrition and Dietetics, Faculty of Health Sciences, Near East University, Northern Cyprus, Cypern
  • Sevinç Yücecan, 1Department of Nutrition and Dietetics, Faculty of Health Sciences, Near East University, Northern Cyprus, Cypern
  • Suresh Inder Singh Rattan
Cynarin (CYN) is the main derivative of caffeoylquinic acid, found in leaves and heads of artichoke. Potential health-beneficial effects of CYN include as being choloretic-cholesterol lowering, hepatoprotective, anti-atherosclerotic, and antioxidative. We have tested the effects of various doses of CYN on the proliferative potential, survival, morphology, and stress response (SR) markers haemoxygenase-1 (HO-1) and heat shock protein-70 (HSP70) in normal human skin fibroblasts (FSF-1), telomerase-immortalized mesenchymal stem cells (hTERT-MSC) and cervical cancer cells, HeLa. Effects of CYN on cell proliferation and morphology were dose- and cell type-dependent, with 500 µM CYN as the upper limit for all cell types. While the growth and proliferation of cells decreased after exposure to 75 µM CYN for 3 days, overall survival of FSF-1 and hTERT-MSC was higher than that of HeLa cells. Furthermore, CYN induced oxidative SR marker HO-1 in both fibroblasts and stem cells in a biphasic manner, but a slight induction of HSP70 was observed only in the stem cells. Thus, CYN may be useful as a protection against the growth and survival of potentially cancerous cells and may promote longevity of normal cells by induction of SR proteins. Further advanced researches related with CYN and artichoke are recommended.
OriginalsprogEngelsk
TidsskriftTurkish Journal of Biology
Vol/bind35
Sider (fra-til)299-305
Antal sider6
ISSN1300-0152
DOI
StatusUdgivet - 30 apr. 2015

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