Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction

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Standard

Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction. / Schaefer, Anne; Im, Heh-In; Venø, Morten T; Fowler, Christie D; Min, Alice; Intrator, Adam; Kjems, Jørgen; Kenny, Paul J; O'Carroll, Donal; Greengard, Paul.

I: Journal of Experimental Medicine, Bind 207, Nr. 9, 30.08.2010, s. 1843-51.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Schaefer, A, Im, H-I, Venø, MT, Fowler, CD, Min, A, Intrator, A, Kjems, J, Kenny, PJ, O'Carroll, D & Greengard, P 2010, 'Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction', Journal of Experimental Medicine, bind 207, nr. 9, s. 1843-51. https://doi.org/10.1084/jem.20100451

APA

Schaefer, A., Im, H-I., Venø, M. T., Fowler, C. D., Min, A., Intrator, A., Kjems, J., Kenny, P. J., O'Carroll, D., & Greengard, P. (2010). Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction. Journal of Experimental Medicine, 207(9), 1843-51. https://doi.org/10.1084/jem.20100451

CBE

Schaefer A, Im H-I, Venø MT, Fowler CD, Min A, Intrator A, Kjems J, Kenny PJ, O'Carroll D, Greengard P. 2010. Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction. Journal of Experimental Medicine. 207(9):1843-51. https://doi.org/10.1084/jem.20100451

MLA

Schaefer, Anne o.a.. "Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction". Journal of Experimental Medicine. 2010, 207(9). 1843-51. https://doi.org/10.1084/jem.20100451

Vancouver

Schaefer A, Im H-I, Venø MT, Fowler CD, Min A, Intrator A o.a. Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction. Journal of Experimental Medicine. 2010 aug 30;207(9):1843-51. https://doi.org/10.1084/jem.20100451

Author

Schaefer, Anne ; Im, Heh-In ; Venø, Morten T ; Fowler, Christie D ; Min, Alice ; Intrator, Adam ; Kjems, Jørgen ; Kenny, Paul J ; O'Carroll, Donal ; Greengard, Paul. / Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction. I: Journal of Experimental Medicine. 2010 ; Bind 207, Nr. 9. s. 1843-51.

Bibtex

@article{49146ffb32a946d6a4b47171d69916db,
title = "Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction",
abstract = "Cocaine is a highly addictive drug that exerts its effects by increasing the levels of released dopamine in the striatum, followed by stable changes in gene transcription, mRNA translation, and metabolism within medium spiny neurons in the striatum. The multiple changes in gene and protein expression associated with cocaine addiction suggest the existence of a mechanism that facilitates a coordinated cellular response to cocaine. Here, we provide evidence for a key role of miRNAs in cocaine addiction. We show that Argonaute 2 (Ago2), which plays an important role in miRNA generation and execution of miRNA-mediated gene silencing, is involved in regulation of cocaine addiction. Deficiency of Ago2 in dopamine 2 receptor (Drd2)-expressing neurons greatly reduces the motivation to self-administer cocaine in mice. We identified a distinct group of miRNAs that is specifically regulated by Ago2 in the striatum. Comparison of miRNAs affected by Ago2 deficiency with miRNAs that are enriched and/or up-regulated in Drd2-neurons in response to cocaine identified a set of miRNAs that are likely to play a role in cocaine addiction.",
keywords = "Animals, Brain, Cell Survival, Cocaine, Cocaine-Related Disorders, Eukaryotic Initiation Factor-2, Female, Male, Mice, Mice, Inbred C57BL, MicroRNAs, Neurons, Receptors, Dopamine D1, Up-Regulation",
author = "Anne Schaefer and Heh-In Im and Ven{\o}, {Morten T} and Fowler, {Christie D} and Alice Min and Adam Intrator and J{\o}rgen Kjems and Kenny, {Paul J} and Donal O'Carroll and Paul Greengard",
year = "2010",
month = aug,
day = "30",
doi = "10.1084/jem.20100451",
language = "English",
volume = "207",
pages = "1843--51",
journal = "Journal of Experimental Medicine",
issn = "0022-1007",
publisher = "Rockefeller University Press",
number = "9",

}

RIS

TY - JOUR

T1 - Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction

AU - Schaefer, Anne

AU - Im, Heh-In

AU - Venø, Morten T

AU - Fowler, Christie D

AU - Min, Alice

AU - Intrator, Adam

AU - Kjems, Jørgen

AU - Kenny, Paul J

AU - O'Carroll, Donal

AU - Greengard, Paul

PY - 2010/8/30

Y1 - 2010/8/30

N2 - Cocaine is a highly addictive drug that exerts its effects by increasing the levels of released dopamine in the striatum, followed by stable changes in gene transcription, mRNA translation, and metabolism within medium spiny neurons in the striatum. The multiple changes in gene and protein expression associated with cocaine addiction suggest the existence of a mechanism that facilitates a coordinated cellular response to cocaine. Here, we provide evidence for a key role of miRNAs in cocaine addiction. We show that Argonaute 2 (Ago2), which plays an important role in miRNA generation and execution of miRNA-mediated gene silencing, is involved in regulation of cocaine addiction. Deficiency of Ago2 in dopamine 2 receptor (Drd2)-expressing neurons greatly reduces the motivation to self-administer cocaine in mice. We identified a distinct group of miRNAs that is specifically regulated by Ago2 in the striatum. Comparison of miRNAs affected by Ago2 deficiency with miRNAs that are enriched and/or up-regulated in Drd2-neurons in response to cocaine identified a set of miRNAs that are likely to play a role in cocaine addiction.

AB - Cocaine is a highly addictive drug that exerts its effects by increasing the levels of released dopamine in the striatum, followed by stable changes in gene transcription, mRNA translation, and metabolism within medium spiny neurons in the striatum. The multiple changes in gene and protein expression associated with cocaine addiction suggest the existence of a mechanism that facilitates a coordinated cellular response to cocaine. Here, we provide evidence for a key role of miRNAs in cocaine addiction. We show that Argonaute 2 (Ago2), which plays an important role in miRNA generation and execution of miRNA-mediated gene silencing, is involved in regulation of cocaine addiction. Deficiency of Ago2 in dopamine 2 receptor (Drd2)-expressing neurons greatly reduces the motivation to self-administer cocaine in mice. We identified a distinct group of miRNAs that is specifically regulated by Ago2 in the striatum. Comparison of miRNAs affected by Ago2 deficiency with miRNAs that are enriched and/or up-regulated in Drd2-neurons in response to cocaine identified a set of miRNAs that are likely to play a role in cocaine addiction.

KW - Animals

KW - Brain

KW - Cell Survival

KW - Cocaine

KW - Cocaine-Related Disorders

KW - Eukaryotic Initiation Factor-2

KW - Female

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - MicroRNAs

KW - Neurons

KW - Receptors, Dopamine D1

KW - Up-Regulation

U2 - 10.1084/jem.20100451

DO - 10.1084/jem.20100451

M3 - Journal article

C2 - 20643829

VL - 207

SP - 1843

EP - 1851

JO - Journal of Experimental Medicine

JF - Journal of Experimental Medicine

SN - 0022-1007

IS - 9

ER -