Aquaporins in complex tissues. II. Subcellular distribution in respiratory and glandular tissues of rat

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Standard

Aquaporins in complex tissues. II. Subcellular distribution in respiratory and glandular tissues of rat. / Nielsen, Søren; King, L S; Christensen, Birgitte Mønster; Agre, P.

I: American Journal of Physiology (Consolidated), Bind 273, Nr. 5 Pt 1, 1997, s. C1549-61.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Nielsen, S, King, LS, Christensen, BM & Agre, P 1997, 'Aquaporins in complex tissues. II. Subcellular distribution in respiratory and glandular tissues of rat', American Journal of Physiology (Consolidated), bind 273, nr. 5 Pt 1, s. C1549-61.

APA

Nielsen, S., King, L. S., Christensen, B. M., & Agre, P. (1997). Aquaporins in complex tissues. II. Subcellular distribution in respiratory and glandular tissues of rat. American Journal of Physiology (Consolidated), 273(5 Pt 1), C1549-61.

CBE

Nielsen S, King LS, Christensen BM, Agre P. 1997. Aquaporins in complex tissues. II. Subcellular distribution in respiratory and glandular tissues of rat. American Journal of Physiology (Consolidated). 273(5 Pt 1):C1549-61.

MLA

Nielsen, Søren o.a.. "Aquaporins in complex tissues. II. Subcellular distribution in respiratory and glandular tissues of rat". American Journal of Physiology (Consolidated). 1997, 273(5 Pt 1). C1549-61.

Vancouver

Nielsen S, King LS, Christensen BM, Agre P. Aquaporins in complex tissues. II. Subcellular distribution in respiratory and glandular tissues of rat. American Journal of Physiology (Consolidated). 1997;273(5 Pt 1):C1549-61.

Author

Nielsen, Søren ; King, L S ; Christensen, Birgitte Mønster ; Agre, P. / Aquaporins in complex tissues. II. Subcellular distribution in respiratory and glandular tissues of rat. I: American Journal of Physiology (Consolidated). 1997 ; Bind 273, Nr. 5 Pt 1. s. C1549-61.

Bibtex

@article{41c448183bfb4a5a9099ef7a6c177735,
title = "Aquaporins in complex tissues. II. Subcellular distribution in respiratory and glandular tissues of rat",
abstract = "The molecular pathways for fluid transport in pulmonary, oral, and nasal tissues are still unresolved. Here we use immunocytochemistry and immunoelectron microscopy to define the sites of expression of four aquaporins in the respiratory tract and glandular epithelia, where they reside in distinct, nonoverlapping sites. Aquaporin-1 (AQP1) is present in apical and basolateral membranes of bronchial, tracheal, and nasopharyngeal vascular endothelium and fibroblasts. AQP5 is localized to the apical plasma membrane of type I pneumocytes and the apical plasma membranes of secretory epithelium in upper airway and salivary glands. In contrast, AQP3 is present in basal cells of tracheal and nasopharyngeal epithelium and is abundant in basolateral membranes of surface epithelial cells of nasal conchus. AQP4 resides in basolateral membranes of columnar cells of bronchial, tracheal, and nasopharyngeal epithelium; in nasal conchus AQP4 is restricted to basolateral membranes of a subset of intra- and subepithelial glands. These sites of expression suggest that transalveolar water movement, modulation of airway surface liquid, air humidification, and generation of nasopharyngeal secretions involve a coordinated network of aquaporin water channels.",
keywords = "Amino Acid Sequence, Animals, Antibodies, Aquaporin 1, Aquaporin 3, Aquaporin 4, Aquaporin 5, Aquaporins, Cell Membrane, Immunohistochemistry, Ion Channels, Male, Membrane Proteins, Microscopy, Immunoelectron, Molecular Sequence Data, Mucous Membrane, Nasal Mucosa, Peptide Fragments, Rats, Rats, Wistar, Respiratory System, Salivary Glands, Subcellular Fractions",
author = "S{\o}ren Nielsen and King, {L S} and Christensen, {Birgitte M{\o}nster} and P Agre",
year = "1997",
language = "English",
volume = "273",
pages = "C1549--61",
journal = "American Journal of Physiology (Consolidated)",
issn = "0002-9513",
publisher = "American Physiological Society",
number = "5 Pt 1",

}

RIS

TY - JOUR

T1 - Aquaporins in complex tissues. II. Subcellular distribution in respiratory and glandular tissues of rat

AU - Nielsen, Søren

AU - King, L S

AU - Christensen, Birgitte Mønster

AU - Agre, P

PY - 1997

Y1 - 1997

N2 - The molecular pathways for fluid transport in pulmonary, oral, and nasal tissues are still unresolved. Here we use immunocytochemistry and immunoelectron microscopy to define the sites of expression of four aquaporins in the respiratory tract and glandular epithelia, where they reside in distinct, nonoverlapping sites. Aquaporin-1 (AQP1) is present in apical and basolateral membranes of bronchial, tracheal, and nasopharyngeal vascular endothelium and fibroblasts. AQP5 is localized to the apical plasma membrane of type I pneumocytes and the apical plasma membranes of secretory epithelium in upper airway and salivary glands. In contrast, AQP3 is present in basal cells of tracheal and nasopharyngeal epithelium and is abundant in basolateral membranes of surface epithelial cells of nasal conchus. AQP4 resides in basolateral membranes of columnar cells of bronchial, tracheal, and nasopharyngeal epithelium; in nasal conchus AQP4 is restricted to basolateral membranes of a subset of intra- and subepithelial glands. These sites of expression suggest that transalveolar water movement, modulation of airway surface liquid, air humidification, and generation of nasopharyngeal secretions involve a coordinated network of aquaporin water channels.

AB - The molecular pathways for fluid transport in pulmonary, oral, and nasal tissues are still unresolved. Here we use immunocytochemistry and immunoelectron microscopy to define the sites of expression of four aquaporins in the respiratory tract and glandular epithelia, where they reside in distinct, nonoverlapping sites. Aquaporin-1 (AQP1) is present in apical and basolateral membranes of bronchial, tracheal, and nasopharyngeal vascular endothelium and fibroblasts. AQP5 is localized to the apical plasma membrane of type I pneumocytes and the apical plasma membranes of secretory epithelium in upper airway and salivary glands. In contrast, AQP3 is present in basal cells of tracheal and nasopharyngeal epithelium and is abundant in basolateral membranes of surface epithelial cells of nasal conchus. AQP4 resides in basolateral membranes of columnar cells of bronchial, tracheal, and nasopharyngeal epithelium; in nasal conchus AQP4 is restricted to basolateral membranes of a subset of intra- and subepithelial glands. These sites of expression suggest that transalveolar water movement, modulation of airway surface liquid, air humidification, and generation of nasopharyngeal secretions involve a coordinated network of aquaporin water channels.

KW - Amino Acid Sequence

KW - Animals

KW - Antibodies

KW - Aquaporin 1

KW - Aquaporin 3

KW - Aquaporin 4

KW - Aquaporin 5

KW - Aquaporins

KW - Cell Membrane

KW - Immunohistochemistry

KW - Ion Channels

KW - Male

KW - Membrane Proteins

KW - Microscopy, Immunoelectron

KW - Molecular Sequence Data

KW - Mucous Membrane

KW - Nasal Mucosa

KW - Peptide Fragments

KW - Rats

KW - Rats, Wistar

KW - Respiratory System

KW - Salivary Glands

KW - Subcellular Fractions

M3 - Journal article

C2 - 9374640

VL - 273

SP - C1549-61

JO - American Journal of Physiology (Consolidated)

JF - American Journal of Physiology (Consolidated)

SN - 0002-9513

IS - 5 Pt 1

ER -