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Aquaporin-5 in breast cancer
Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Review › Forskning › peer review
Dokumenter
- APMIS - 2022 - Bystrup - Aquaporin‐5 in breast cancer
Forlagets udgivne version, 570 KB, PDF-dokument
DOI
- https://doi.org/10.1111/apm.13212
Forlagets udgivne version
- Malte Bystrup ,
- Frédéric H. Login
- Sarannya E
- Signe Borgquist
- Trine Tramm
- Tae-Hwan Kwon, Kyungpook National University, Sydkorea
- Lene Niemann Nejsum
The water channel aquaporin-5 (AQP5) is essential in transepithelial water transport in secretory glands. AQP5 is ectopically overexpressed in breast cancer, where expression is associated with lymph node metastasis and poor prognosis. Besides the role in water transport, AQP5 has been found to play a role in cancer metastasis, migration, and proliferation. AQP5 has also been shown to be involved in the dysregulation of epithelial cell–cell adhesion; frequently observed in cancers. Insight into the underlying molecular mechanisms of how AQP5 contributes to cancer development and progression is essential for potentially implementing AQP5 as a prognostic biomarker and to develop targeted intervention strategies for the treatment of breast cancer patients.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica |
| Vol/bind | 130 |
| Nummer | 5 |
| Sider (fra-til) | 253-260 |
| Antal sider | 8 |
| ISSN | 0903-4641 |
| DOI | |
| Status | Udgivet - maj 2022 |
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