Projekter pr. år
Abstract
Deficiency of apolipoprotein E (APOE) causes familial dysbetalipoproteinemia in humans resulting in a higher risk of atherosclerotic disease. In mice, APOE deficiency results in a severe atherosclerosis phenotype, but it is unknown to what extent this is unique to mice. In this study, APOE was targeted in Yucatan minipigs. APOE −/− minipigs displayed increased plasma cholesterol and accumulation of apolipoprotein B-48–containing chylomicron remnants on low-fat diet, which was significantly accentuated upon feeding a high-fat, high-cholesterol diet. APOE −/− minipigs displayed accelerated progressive atherosclerosis but not xanthoma formation. This indicates that remnant lipoproteinemia does not induce early lesions but is atherogenic in pre-existing atherosclerosis.
Originalsprog | Engelsk |
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Tidsskrift | JACC: Basic to translational science |
Vol/bind | 2 |
Nummer | 5 |
Sider (fra-til) | 591-600 |
Antal sider | 10 |
ISSN | 2452-302X |
DOI | |
Status | Udgivet - okt. 2017 |
Fingeraftryk
Dyk ned i forskningsemnerne om 'Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs'. Sammen danner de et unikt fingeraftryk.Projekter
- 3 Afsluttet
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ICT-AGRI HappyCow
Grøn Sørensen, C. (Deltager), Nørremark, M. (Deltager) & Jørgensen, O. (Deltager)
15/09/2014 → 31/12/2016
Projekter: Projekt › Forskning
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Pig cloning - made in Denmark
Liu, Y. (Deltager), Li, R. (Deltager) & Callesen, H. (Deltager)
01/01/2014 → 31/12/2014
Projekter: Projekt › Forskning
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DAGMAR: Danish Genetically Modified Animal Ressource
Adamsen, J. B. F. (Deltager), Villemoes, K. (Deltager), Pedersen, A. M. (Deltager), Kristensen, R. (Deltager), Liu, Y. (Deltager), Li, R. (Deltager), Callesen, H. (Deltager), Nykjaer, A. (Deltager), Bentzon, J. (Deltager), Jørgensen, A. L. (Deltager), Jakobsen, J. (Deltager), Sørensen, C. B. (Deltager), Luo, Y. (Deltager), Bolund, L. (Deltager) & Pedersen, O. G. (Deltager)
01/01/2009 → 31/12/2014
Projekter: Projekt › Forskning