Antiresorptive Therapy for Osteoporosis in Older Subjects

TY - JOUR

T1 - Antiresorptive Therapy for Osteoporosis in Older Subjects

AU - Sølling, Anne Sophie

AU - Laursen, Natasha Amran

AU - Harsløf, Torben

AU - Langdahl, Bente Lomholt

PY - 2025/4/1

Y1 - 2025/4/1

N2 - Background: Osteoporosis increases the risk of fractures and mortality, particularly in the elderly population. However, prescribing antiresorptive medication to elderly patients with osteoporosis is complex. The benefitrisk ratio should be considered for all patients but can be particularly challenging in older individuals due to factors like comorbidities, polypharmacy, fall risk, and potential rare side effects of long-Term treatment. Summary: We reviewed the efficacy and safety of antiresorptive treatments, including calcium and vitamin D supplementation, in elderly patients by evaluating published trials, reviews, and meta-Analyses. Our findings confirm that antiresorptive treatment for osteoporosis is both effective and safe in the elderly population. Key Messages: One key challenge is ensuring compliance, which can be difficult for some elderly patients. In such cases, intravenously or subcutaneously administered antiresorptive treatment should be considered to improve adherence and overall treatment compliance.

AB - Background: Osteoporosis increases the risk of fractures and mortality, particularly in the elderly population. However, prescribing antiresorptive medication to elderly patients with osteoporosis is complex. The benefitrisk ratio should be considered for all patients but can be particularly challenging in older individuals due to factors like comorbidities, polypharmacy, fall risk, and potential rare side effects of long-Term treatment. Summary: We reviewed the efficacy and safety of antiresorptive treatments, including calcium and vitamin D supplementation, in elderly patients by evaluating published trials, reviews, and meta-Analyses. Our findings confirm that antiresorptive treatment for osteoporosis is both effective and safe in the elderly population. Key Messages: One key challenge is ensuring compliance, which can be difficult for some elderly patients. In such cases, intravenously or subcutaneously administered antiresorptive treatment should be considered to improve adherence and overall treatment compliance.

KW - Antiresorptives

KW - Bone mineral density

KW - Elderly

KW - Fracture

KW - Osteoporosis

KW - Safety

UR - http://www.scopus.com/inward/record.url?scp=105003473797&partnerID=8YFLogxK

U2 - 10.1159/000544781

DO - 10.1159/000544781

M3 - Journal article

AN - SCOPUS:105003473797

SN - 0304-324X

VL - 71

SP - 297

EP - 307

JO - Gerontology

JF - Gerontology

IS - 4

ER -