Antioxidant Microgels Support Peroxide-Challenged Hepatic Cells

Isabella Nymann Westensee; Karen Louise Thomsen; Rajeshwar Prosad Mookerjee; Brigitte Maria Stadler

doi:10.1002/adbi.202300547

Antioxidant Microgels Support Peroxide-Challenged Hepatic Cells

Isabella Nymann Westensee, Karen Louise Thomsen, Rajeshwar Prosad Mookerjee, Brigitte Maria Stadler^*

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

1 Citationer (Scopus)

Abstract

Access to therapeutic strategies that counter cellular stress induced by reactive oxygen species (ROS) is an important, long-standing challenge. Here, the assembly of antioxidant artificial cells is based on alginate hydrogels equipped with non-native catalysts, namely platinum nanoparticles and an EUK compound. These artificial cells are able to preserve the viability and lower the intracellular ROS levels of challenged hepatic cells by removing peroxides from the extracellular environment. Conceptually, this strategy illustrates the potential use of artificial cells with a synthetic catalyst toward long-term support of hepatic cells and potentially other mammalian cells.

Originalsprog	Engelsk
Artikelnummer	e2300547
Tidsskrift	Advanced Biology
Vol/bind	8
Nummer	4
Antal sider	10
ISSN	2701-0198
DOI	https://doi.org/10.1002/adbi.202300547
Status	Udgivet - apr. 2024

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10.1002/adbi.202300547Licens: CC BY

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title = "Antioxidant Microgels Support Peroxide-Challenged Hepatic Cells",

abstract = "Access to therapeutic strategies that counter cellular stress induced by reactive oxygen species (ROS) is an important, long-standing challenge. Here, the assembly of antioxidant artificial cells is based on alginate hydrogels equipped with non-native catalysts, namely platinum nanoparticles and an EUK compound. These artificial cells are able to preserve the viability and lower the intracellular ROS levels of challenged hepatic cells by removing peroxides from the extracellular environment. Conceptually, this strategy illustrates the potential use of artificial cells with a synthetic catalyst toward long-term support of hepatic cells and potentially other mammalian cells.",

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author = "Westensee, {Isabella Nymann} and Thomsen, {Karen Louise} and Mookerjee, {Rajeshwar Prosad} and Stadler, {Brigitte Maria}",

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AU - Westensee, Isabella Nymann

AU - Thomsen, Karen Louise

AU - Mookerjee, Rajeshwar Prosad

AU - Stadler, Brigitte Maria

PY - 2024/4

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N2 - Access to therapeutic strategies that counter cellular stress induced by reactive oxygen species (ROS) is an important, long-standing challenge. Here, the assembly of antioxidant artificial cells is based on alginate hydrogels equipped with non-native catalysts, namely platinum nanoparticles and an EUK compound. These artificial cells are able to preserve the viability and lower the intracellular ROS levels of challenged hepatic cells by removing peroxides from the extracellular environment. Conceptually, this strategy illustrates the potential use of artificial cells with a synthetic catalyst toward long-term support of hepatic cells and potentially other mammalian cells.

AB - Access to therapeutic strategies that counter cellular stress induced by reactive oxygen species (ROS) is an important, long-standing challenge. Here, the assembly of antioxidant artificial cells is based on alginate hydrogels equipped with non-native catalysts, namely platinum nanoparticles and an EUK compound. These artificial cells are able to preserve the viability and lower the intracellular ROS levels of challenged hepatic cells by removing peroxides from the extracellular environment. Conceptually, this strategy illustrates the potential use of artificial cells with a synthetic catalyst toward long-term support of hepatic cells and potentially other mammalian cells.

KW - Animals

KW - Antioxidants/pharmacology

KW - Hepatocytes

KW - Mammals

KW - Metal Nanoparticles

KW - Microgels

KW - Peroxides

KW - Platinum

KW - Reactive Oxygen Species

KW - antioxidants

KW - hydrogels

KW - EUK compounds

KW - hepatocytes

KW - reactive oxygen species

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DO - 10.1002/adbi.202300547

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VL - 8

JO - Advanced Biology

JF - Advanced Biology

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Antioxidant Microgels Support Peroxide-Challenged Hepatic Cells

Abstract

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