Antibacterial and antioxidant wound dressings with pH responsive release properties accelerate chronic wound healing

Wuxiu Cao; Dan Xia; Linxi Zhou; Yuan Liu; Donghui Wang; Chunyong Liang; Menglin Chen

doi:10.1016/j.mtphys.2023.101316

Antibacterial and antioxidant wound dressings with pH responsive release properties accelerate chronic wound healing

Wuxiu Cao, Dan Xia^*, Linxi Zhou, Yuan Liu, Donghui Wang^*, Chunyong Liang, Menglin Chen^*

^*Corresponding author af dette arbejde

Institut for Bio- og Kemiteknologi - Medical Biotechnology - Gustav Wieds Vej 10D

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

15 Citationer (Scopus)

Abstract

Accelerating chronic wound healing is of great clinical significance. In this study, a bilayer pad (PCL-TH/PVA-Alg@CUR) with tetracycline hydrochloride (TH) loaded polycaprolactone (PCL) nanofiber as the outer layer (PCL-TH), and poly (vinyl alcohol) (PVA) hydrogel loaded with sodium alginate microspheres (Alg) encapsulating of curcumin (CUR) as the inner layer (PVA-Alg@CUR) was prepared to accelerate the chronic wound healing. The prepared bilayer pad shows a porous structure and can release CUR specifically according to the pH of chronic wounds. Moreover, it has good water vapor transmittance and water absorption ability, and its mechanical properties can meet the daily expansion and contraction of the skin. The antimicrobial and antioxidant properties of the bilayer pads were verified by the inhibition zone, co-culture method and in vitro free radical scavenging experiments. In addition, in vivo experiments have shown that the bilayer pad can inhibit the bacteria at the wound site and accelerate the healing of the chronic diabetic wound infected by bacteria. This study indicates the prepared antibacterial and antioxidant bilayer dressing with pH responsive release property have potential clinical applications.

Originalsprog	Engelsk
Artikelnummer	101316
Tidsskrift	Materials Today Physics
Vol/bind	40
ISSN	2542-5293
DOI	https://doi.org/10.1016/j.mtphys.2023.101316
Status	Udgivet - jan. 2024

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10.1016/j.mtphys.2023.101316

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title = "Antibacterial and antioxidant wound dressings with pH responsive release properties accelerate chronic wound healing",

abstract = "Accelerating chronic wound healing is of great clinical significance. In this study, a bilayer pad (PCL-TH/PVA-Alg@CUR) with tetracycline hydrochloride (TH) loaded polycaprolactone (PCL) nanofiber as the outer layer (PCL-TH), and poly (vinyl alcohol) (PVA) hydrogel loaded with sodium alginate microspheres (Alg) encapsulating of curcumin (CUR) as the inner layer (PVA-Alg@CUR) was prepared to accelerate the chronic wound healing. The prepared bilayer pad shows a porous structure and can release CUR specifically according to the pH of chronic wounds. Moreover, it has good water vapor transmittance and water absorption ability, and its mechanical properties can meet the daily expansion and contraction of the skin. The antimicrobial and antioxidant properties of the bilayer pads were verified by the inhibition zone, co-culture method and in vitro free radical scavenging experiments. In addition, in vivo experiments have shown that the bilayer pad can inhibit the bacteria at the wound site and accelerate the healing of the chronic diabetic wound infected by bacteria. This study indicates the prepared antibacterial and antioxidant bilayer dressing with pH responsive release property have potential clinical applications.",

keywords = "Antimicrobial, Antioxidant, Chronic wound healing, pH responsive release",

author = "Wuxiu Cao and Dan Xia and Linxi Zhou and Yuan Liu and Donghui Wang and Chunyong Liang and Menglin Chen",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Ltd",

year = "2024",

month = jan,

doi = "10.1016/j.mtphys.2023.101316",

language = "English",

volume = "40",

journal = "Materials Today Physics",

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TY - JOUR

T1 - Antibacterial and antioxidant wound dressings with pH responsive release properties accelerate chronic wound healing

AU - Cao, Wuxiu

AU - Xia, Dan

AU - Zhou, Linxi

AU - Liu, Yuan

AU - Wang, Donghui

AU - Liang, Chunyong

AU - Chen, Menglin

PY - 2024/1

Y1 - 2024/1

N2 - Accelerating chronic wound healing is of great clinical significance. In this study, a bilayer pad (PCL-TH/PVA-Alg@CUR) with tetracycline hydrochloride (TH) loaded polycaprolactone (PCL) nanofiber as the outer layer (PCL-TH), and poly (vinyl alcohol) (PVA) hydrogel loaded with sodium alginate microspheres (Alg) encapsulating of curcumin (CUR) as the inner layer (PVA-Alg@CUR) was prepared to accelerate the chronic wound healing. The prepared bilayer pad shows a porous structure and can release CUR specifically according to the pH of chronic wounds. Moreover, it has good water vapor transmittance and water absorption ability, and its mechanical properties can meet the daily expansion and contraction of the skin. The antimicrobial and antioxidant properties of the bilayer pads were verified by the inhibition zone, co-culture method and in vitro free radical scavenging experiments. In addition, in vivo experiments have shown that the bilayer pad can inhibit the bacteria at the wound site and accelerate the healing of the chronic diabetic wound infected by bacteria. This study indicates the prepared antibacterial and antioxidant bilayer dressing with pH responsive release property have potential clinical applications.

AB - Accelerating chronic wound healing is of great clinical significance. In this study, a bilayer pad (PCL-TH/PVA-Alg@CUR) with tetracycline hydrochloride (TH) loaded polycaprolactone (PCL) nanofiber as the outer layer (PCL-TH), and poly (vinyl alcohol) (PVA) hydrogel loaded with sodium alginate microspheres (Alg) encapsulating of curcumin (CUR) as the inner layer (PVA-Alg@CUR) was prepared to accelerate the chronic wound healing. The prepared bilayer pad shows a porous structure and can release CUR specifically according to the pH of chronic wounds. Moreover, it has good water vapor transmittance and water absorption ability, and its mechanical properties can meet the daily expansion and contraction of the skin. The antimicrobial and antioxidant properties of the bilayer pads were verified by the inhibition zone, co-culture method and in vitro free radical scavenging experiments. In addition, in vivo experiments have shown that the bilayer pad can inhibit the bacteria at the wound site and accelerate the healing of the chronic diabetic wound infected by bacteria. This study indicates the prepared antibacterial and antioxidant bilayer dressing with pH responsive release property have potential clinical applications.

KW - Antimicrobial

KW - Antioxidant

KW - Chronic wound healing

KW - pH responsive release

U2 - 10.1016/j.mtphys.2023.101316

DO - 10.1016/j.mtphys.2023.101316

M3 - Journal article

AN - SCOPUS:85180528034

SN - 2542-5293

VL - 40

JO - Materials Today Physics

JF - Materials Today Physics

M1 - 101316

ER -

Antibacterial and antioxidant wound dressings with pH responsive release properties accelerate chronic wound healing

Abstract

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