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Annelid genomes: Enchytraeus crypticus, a soil model for the innate (and primed) immune system

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DOI

  • Mónica J.B. Amorim, University of Aveiro
  • ,
  • Yannick Gansemans, Ghent University
  • ,
  • Susana I.L. Gomes, University of Aveiro
  • ,
  • Filip Van Nieuwerburgh, Ghent University
  • ,
  • Janeck J. Scott-Fordsmand

Enchytraeids (Annelida) are soil invertebrates with worldwide distribution that have served as ecotoxicology models for over 20 years. We present the first high-quality reference genome of Enchytraeus crypticus, assembled from a combination of Pacific Bioscience single-molecule real-time and Illumina sequencing platforms as a 525.2 Mbp genome (910 gapless scaffolds and 18,452 genes). We highlight isopenicillin, acquired by horizontal gene transfer and conferring antibiotic function. Significant gene family expansions associated with regeneration (long interspersed nuclear elements), the innate immune system (tripartite motif-containing protein) and response to stress (cytochrome P450) were identified. The ACE (Angiotensin-converting enzyme) — a homolog of ACE2, which is involved in the coronavirus SARS-CoV-2 cell entry — is also present in E. crypticus. There is an obvious potential of using E. crypticus as a model to study interactions between regeneration, the innate immune system and aging-dependent decline.

OriginalsprogEngelsk
TidsskriftLab Animal
Vol/bind50
Sider (fra-til)285–294
ISSN0093-7355
DOI
StatusUdgivet - okt. 2021

Bibliografisk note

Funding Information:
This study received funding from the European Commission within NanoInformaTIX (H2020-NMBP-14-2018, No. 814426), BIORIMA (H2020-NMBP-12-2017 GA No. 760928) and NANORIGO (H2020-NMBP-13-2018, GA No. 814530) projects, FCT (Fundação para a Ciência e Tecnologia)/MCTES (Ministério da Ciência e Tecnologia do Ensino Superior) for financial support of project BEAUTY: Big gEnome wide Applications for an ecotoxicology soil model – a knowledge base to Unravel mechanisms (nanopesTY_cides) (PTDC/CTA-AMB/3970/2020) and CESAM (UIDP/50017/2020+ UIDB/50017/2020). S.I.L.G. is funded by national funds (OE), through FCT – Fundação para a Ciência e a Tecnologia, I.P., in the scope of the framework contract foreseen in the numbers 4, 5 and 6 of the article 23, of the Decree-Law 57/2016, of August 29, changed by Law 57/2017, of July 19.

Publisher Copyright:
© 2021, The Author(s).

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