Androgen supplementation in assisted reproduction: where are we in 2019?

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

  • Pedro Montoya-Botero, Conceptum - Unidad de Fertilidad del Country
  • ,
  • Jorge Rodriguez-Purata, Dexeus Univ Hosp, Dept Reprod Med
  • ,
  • Nikolaos P. Polyzos, Dexeus Univ Hosp, Dept Reprod Med, Vrije Univ Brussel, Vrije Universiteit Brussel, Fac Med & Pharm, Dept Surg & Clin Sci

Purpose of review

The purpose of this review is to provide an overview of androgen supplementation in ART with the most updated evidence, from animal studies to its clinical applications in poor ovarian responders (POR) and the future studies to be published.

Recent findings

Animal studies, has shown that testosterone supplementation, can be an option to increase the recruitable follicular pool in POR. However, the potential mechanism of action, dose, and duration of treatment is still under investigation. Early studies in humans reported promising results in favor of androgens [dehydroepiandrosterone (DHEA) or testosterone] in POR. Nevertheless, recent evidence does not appear to follow the initial results, whereas the type, dose, and duration of testosterone administration appear to be crucial for treatment effect.

Summary

Testosterone seems to play an essential role in regulating ovarian function. However, it is worrisome that androgens are used off-label, despite that the available evidence is weak. Although testosterone supplementation may be beneficial in POR, published studies have used inconsistent doses and duration of administration. An ongoing trial (T-TRANSPORT trial) for the first time aims to provide conclusive evidence on whether transdermal testosterone administration can improve the reproductive outcomes in patients undergoing IVF/ICSI.

OriginalsprogEngelsk
TidsskriftCurrent Opinion in Obstetrics & Gynecology
Vol/bind31
Nummer3
Sider (fra-til)188-194
Antal sider7
ISSN1040-872X
DOI
StatusUdgivet - jun. 2019

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