TY - JOUR
T1 - Analysis of lineage-specific Alu subfamilies in the genome of the olive baboon, Papio anubis
AU - Steely, Cody J.
AU - Baker, Jasmine N.
AU - Walker, Jerilyn A.
AU - Loupe, Charles D.
AU - Batzer, Mark A.
AU - Rogers, Jeffrey
AU - Harris, R. Alan
AU - Raveendran, Muthuswamy
AU - Liu, Yue
AU - Murali, Shwetha
AU - Vilgalys, Tauras P.
AU - Walker, Jerilyn A.
AU - Konkel, Miriam K.
AU - Jordan, Vallmer E.
AU - Steely, Cody J.
AU - Beckstrom, Thomas O.
AU - Thomas, Gregg W.C.
AU - Pagel, Kymberleigh A.
AU - Pejaver, Vikas
AU - Catacchio, Claudia R.
AU - Archidiacono, Nicoletta
AU - Ventura, Mario
AU - Marra-Campanale, Alessia
AU - Palazzo, Antonio
AU - Capozzi, Oronzo
AU - Raja, Archana
AU - Huddleston, John
AU - Quick, Veronica Searles
AU - Karimpour-Fard, Anis
AU - Schrempf, Dominik
AU - de Manuel Montero, Marc
AU - Billis, Konstantinos
AU - Martin, Fergal J.
AU - Muffato, Matthieu
AU - Athanasiadis, Georgios
AU - Bergey, Christina
AU - Burrell, Andrew
AU - Cheng, Jade
AU - Cox, Laura
AU - Else, James
AU - Han, Yi
AU - Kopp, Gisela H.
AU - Kothe, Maximilian
AU - Leppälä, Kalle
AU - Noll, Angela
AU - Pecotte, Jera
AU - Pipes, Lenore
AU - Munch, Kasper
AU - Mailund, Thomas
AU - Schierup, Mikkel
AU - The Baboon Genome Analysis Consortium
PY - 2018/3/19
Y1 - 2018/3/19
N2 - Background: Alu elements are primate-specific retroposons that mobilize using the enzymatic machinery of L1 s. The recently completed baboon genome project found that the mobilization rate of Alu elements is higher than in the genome of any other primate studied thus far. However, the Alu subfamily structure present in and specific to baboons had not been examined yet. Results: Here we report 129 Alu subfamilies that are propagating in the genome of the olive baboon, with 127 of these subfamilies being new and specific to the baboon lineage. We analyzed 233 Alu insertions in the genome of the olive baboon using locus specific polymerase chain reaction assays, covering 113 of the 129 subfamilies. The allele frequency data from these insertions show that none of the nine groups of subfamilies are nearing fixation in the lineage. Conclusions: Many subfamilies of Alu elements are actively mobilizing throughout the baboon lineage, with most being specific to the baboon lineage.
AB - Background: Alu elements are primate-specific retroposons that mobilize using the enzymatic machinery of L1 s. The recently completed baboon genome project found that the mobilization rate of Alu elements is higher than in the genome of any other primate studied thus far. However, the Alu subfamily structure present in and specific to baboons had not been examined yet. Results: Here we report 129 Alu subfamilies that are propagating in the genome of the olive baboon, with 127 of these subfamilies being new and specific to the baboon lineage. We analyzed 233 Alu insertions in the genome of the olive baboon using locus specific polymerase chain reaction assays, covering 113 of the 129 subfamilies. The allele frequency data from these insertions show that none of the nine groups of subfamilies are nearing fixation in the lineage. Conclusions: Many subfamilies of Alu elements are actively mobilizing throughout the baboon lineage, with most being specific to the baboon lineage.
KW - Alu
KW - Baboon
KW - Papio
KW - Subfamily
U2 - 10.1186/s13100-018-0115-6
DO - 10.1186/s13100-018-0115-6
M3 - Journal article
C2 - 29560044
AN - SCOPUS:85044182302
SN - 1383-469X
VL - 9
JO - Mobile DNA
JF - Mobile DNA
IS - 1
M1 - 10
ER -