An untapped potential for imaging of peripheral osteomyelitis in paediatrics using [F-18]FDG PET/CTthe inference from a juvenile porcine model

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An untapped potential for imaging of peripheral osteomyelitis in paediatrics using [F-18]FDG PET/CTthe inference from a juvenile porcine model. / Afzelius, P.; Nielsen, O. L.; Schonheyder, H. C.; Alstrup, A. K. O.; Hansen, S. B.

I: EJNMMI Research, Bind 9, 29, 22.03.2019.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{f6fad26ccbec4eefa7046d4fe33afb5b,
title = "An untapped potential for imaging of peripheral osteomyelitis in paediatrics using [F-18]FDG PET/CTthe inference from a juvenile porcine model",
abstract = "PurposeTo examine parameters affecting the detection of osteomyelitis (OM) by [F-18]FDG PET/CT and to reduce tracer activity in a pig model.Background[F-18]FDG PET/CT is recommended for the diagnosis of OM in the axial skeleton of adults. In children, OM has a tendency to become chronic or recurrent, especially in low-income countries. Early diagnosis and initiation of therapy are therefore essential. We have previously demonstrated that [F-18]FDG PET/CT is promising in juvenile Staphylococcus aureus (S. aureus) OM of peripheral bones in a pig model, not failing even small lesions. When using imaging in children, radiation exposure should be balanced against fast diagnostics in the individual case.MethodsTwenty juvenile pigs were inoculated with S. aureus. One week after inoculation, the pigs were [F-18]FDG PET/CT scanned. PET list-mode acquired data of a subgroup were retrospectively processed in order to simulate and examine the image quality obtainable with an injected activity of 132MBq, 44MBq, 13.2MBq, and 4.4MBq, respectively.ResultsAll lesions were detected by [F-18]FDG PET and CT. Some lesions were very small (0.01cm(3)), and others were larger (4.18cm(3)). SUVmax was higher when sequesters (p=0.023) and fistulas were formed (p",
keywords = "Osteomyelitis, [F-18]FDG PET, CT, Dose reduction, Children, Juvenile pigs, Staphylococcus aureus, STAPHYLOCOCCUS-AUREUS OSTEOMYELITIS, ITERATIVE RECONSTRUCTION, COMPUTED-TOMOGRAPHY, BONE, C-11-METHIONINE, F-18-FDG, GA-68-CITRATE, C-11-PK11195, INFLAMMATION, INFECTIONS",
author = "P. Afzelius and Nielsen, {O. L.} and Schonheyder, {H. C.} and Alstrup, {A. K. O.} and Hansen, {S. B.}",
year = "2019",
month = mar,
day = "22",
doi = "10.1186/s13550-019-0498-5",
language = "English",
volume = "9",
journal = "EJNMMI Research",
issn = "2191-219X",
publisher = "SpringerOpen",

}

RIS

TY - JOUR

T1 - An untapped potential for imaging of peripheral osteomyelitis in paediatrics using [F-18]FDG PET/CTthe inference from a juvenile porcine model

AU - Afzelius, P.

AU - Nielsen, O. L.

AU - Schonheyder, H. C.

AU - Alstrup, A. K. O.

AU - Hansen, S. B.

PY - 2019/3/22

Y1 - 2019/3/22

N2 - PurposeTo examine parameters affecting the detection of osteomyelitis (OM) by [F-18]FDG PET/CT and to reduce tracer activity in a pig model.Background[F-18]FDG PET/CT is recommended for the diagnosis of OM in the axial skeleton of adults. In children, OM has a tendency to become chronic or recurrent, especially in low-income countries. Early diagnosis and initiation of therapy are therefore essential. We have previously demonstrated that [F-18]FDG PET/CT is promising in juvenile Staphylococcus aureus (S. aureus) OM of peripheral bones in a pig model, not failing even small lesions. When using imaging in children, radiation exposure should be balanced against fast diagnostics in the individual case.MethodsTwenty juvenile pigs were inoculated with S. aureus. One week after inoculation, the pigs were [F-18]FDG PET/CT scanned. PET list-mode acquired data of a subgroup were retrospectively processed in order to simulate and examine the image quality obtainable with an injected activity of 132MBq, 44MBq, 13.2MBq, and 4.4MBq, respectively.ResultsAll lesions were detected by [F-18]FDG PET and CT. Some lesions were very small (0.01cm(3)), and others were larger (4.18cm(3)). SUVmax was higher when sequesters (p=0.023) and fistulas were formed (p

AB - PurposeTo examine parameters affecting the detection of osteomyelitis (OM) by [F-18]FDG PET/CT and to reduce tracer activity in a pig model.Background[F-18]FDG PET/CT is recommended for the diagnosis of OM in the axial skeleton of adults. In children, OM has a tendency to become chronic or recurrent, especially in low-income countries. Early diagnosis and initiation of therapy are therefore essential. We have previously demonstrated that [F-18]FDG PET/CT is promising in juvenile Staphylococcus aureus (S. aureus) OM of peripheral bones in a pig model, not failing even small lesions. When using imaging in children, radiation exposure should be balanced against fast diagnostics in the individual case.MethodsTwenty juvenile pigs were inoculated with S. aureus. One week after inoculation, the pigs were [F-18]FDG PET/CT scanned. PET list-mode acquired data of a subgroup were retrospectively processed in order to simulate and examine the image quality obtainable with an injected activity of 132MBq, 44MBq, 13.2MBq, and 4.4MBq, respectively.ResultsAll lesions were detected by [F-18]FDG PET and CT. Some lesions were very small (0.01cm(3)), and others were larger (4.18cm(3)). SUVmax was higher when sequesters (p=0.023) and fistulas were formed (p

KW - Osteomyelitis

KW - [F-18]FDG PET

KW - CT

KW - Dose reduction

KW - Children

KW - Juvenile pigs

KW - Staphylococcus aureus

KW - STAPHYLOCOCCUS-AUREUS OSTEOMYELITIS

KW - ITERATIVE RECONSTRUCTION

KW - COMPUTED-TOMOGRAPHY

KW - BONE

KW - C-11-METHIONINE

KW - F-18-FDG

KW - GA-68-CITRATE

KW - C-11-PK11195

KW - INFLAMMATION

KW - INFECTIONS

U2 - 10.1186/s13550-019-0498-5

DO - 10.1186/s13550-019-0498-5

M3 - Journal article

C2 - 30903403

VL - 9

JO - EJNMMI Research

JF - EJNMMI Research

SN - 2191-219X

M1 - 29

ER -