An untapped potential for imaging of peripheral osteomyelitis in paediatrics using [F-18]FDG PET/CTthe inference from a juvenile porcine model

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  • P. Afzelius, Aalborg Univ Hosp, Aalborg University, Clin Canc Res Ctr, Dept Nucl Med
  • ,
  • O. L. Nielsen, Univ Copenhagen, University of Copenhagen, Dept Vet Clin & Anim Sci, Fac Med & Hlth Sci
  • ,
  • H. C. Schonheyder, Aalborg Univ Hosp, Aalborg University, Dept Clin Microbiol, Aalborg Univ, Aalborg University, Dept Clin Med
  • ,
  • A. K. O. Alstrup
  • S. B. Hansen

PurposeTo examine parameters affecting the detection of osteomyelitis (OM) by [F-18]FDG PET/CT and to reduce tracer activity in a pig model.Background[F-18]FDG PET/CT is recommended for the diagnosis of OM in the axial skeleton of adults. In children, OM has a tendency to become chronic or recurrent, especially in low-income countries. Early diagnosis and initiation of therapy are therefore essential. We have previously demonstrated that [F-18]FDG PET/CT is promising in juvenile Staphylococcus aureus (S. aureus) OM of peripheral bones in a pig model, not failing even small lesions. When using imaging in children, radiation exposure should be balanced against fast diagnostics in the individual case.MethodsTwenty juvenile pigs were inoculated with S. aureus. One week after inoculation, the pigs were [F-18]FDG PET/CT scanned. PET list-mode acquired data of a subgroup were retrospectively processed in order to simulate and examine the image quality obtainable with an injected activity of 132MBq, 44MBq, 13.2MBq, and 4.4MBq, respectively.ResultsAll lesions were detected by [F-18]FDG PET and CT. Some lesions were very small (0.01cm(3)), and others were larger (4.18cm(3)). SUVmax was higher when sequesters (p=0.023) and fistulas were formed (p

OriginalsprogEngelsk
Artikelnummer29
TidsskriftEJNMMI Research
Vol/bind9
Antal sider9
ISSN2191-219X
DOI
StatusUdgivet - 22 mar. 2019

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