An Ultrasonically-Powered System for 1.06mm3 Implantable Optogenetics and Drug Delivery Dust

Kjeld Laursen; Milad Zamani; Yasser Rezaeiyan; Seyedsina Hosseini; Tanmay Mondal; Brian Corbett; Abdel Mouttalib Ouagazzal; Marianne Amalric; Farshad Moradi

doi:10.1109/TCSII.2023.3289028

An Ultrasonically-Powered System for 1.06mm³ Implantable Optogenetics and Drug Delivery Dust

Kjeld Laursen, Milad Zamani, Yasser Rezaeiyan, Seyedsina Hosseini, Tanmay Mondal, Brian Corbett, Abdel Mouttalib Ouagazzal, Marianne Amalric, Farshad Moradi

Institut for Elektro- og Computerteknologi - Electronics and Photonics

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

5 Citationer (Scopus)

Abstract

This paper presents an ultrasonically powered micro-system for deep tissue optogenetic stimulation. The developed system is composed of a Base for Powering and Controlling (BPC) and an implantable Dust for optogenetics and drug delivery. The Dust consists of a piezoelectric crystal, a rectifier chip, and a micro-scale custom-designed light-emitting-diode (μLED) integrated, miniaturized, and envisioned to be used for freely moving animal studies. The proposed Dust operates in frequencies up to 5 MHz, power levels in the 0–10 mW range, achieves start-up within 1.8 μs at 2.9 MHz operating frequency at 14.4 mW/mm2 ultrasound power density, and 98.1% chip efficiency at 2 mW input power. With the BPC implemented and attached to (500 μm)3 PZT4 crystals, set to 60 V at 2.8 MHz operating frequency at 3 mm distance in demineralized water, the dust delivered up to 6 mW to its load (μLED for optogenetics), which translates to 0.11% total system efficiency.

Originalsprog	Engelsk
Tidsskrift	IEEE Transactions on Circuits and Systems II: Express Briefs
Vol/bind	70
Nummer	10
Sider (fra-til)	3937-3941
Antal sider	5
ISSN	1549-7747
DOI	https://doi.org/10.1109/TCSII.2023.3289028
Status	Udgivet - 1 okt. 2023

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10.1109/TCSII.2023.3289028

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Link to publication in Scopus

Citationsformater

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title = "An Ultrasonically-Powered System for 1.06mm3 Implantable Optogenetics and Drug Delivery Dust",

abstract = "This paper presents an ultrasonically powered micro-system for deep tissue optogenetic stimulation. The developed system is composed of a Base for Powering and Controlling (BPC) and an implantable Dust for optogenetics and drug delivery. The Dust consists of a piezoelectric crystal, a rectifier chip, and a micro-scale custom-designed light-emitting-diode (μLED) integrated, miniaturized, and envisioned to be used for freely moving animal studies. The proposed Dust operates in frequencies up to 5 MHz, power levels in the 0–10 mW range, achieves start-up within 1.8 μs at 2.9 MHz operating frequency at 14.4 mW/mm2 ultrasound power density, and 98.1% chip efficiency at 2 mW input power. With the BPC implemented and attached to (500 μm)3 PZT4 crystals, set to 60 V at 2.8 MHz operating frequency at 3 mm distance in demineralized water, the dust delivered up to 6 mW to its load (μLED for optogenetics), which translates to 0.11% total system efficiency.",

keywords = "Bridge circuits, Crystals, Dust, Light emitting diodes, Logic gates, Optogenetic stimulation, Optogenetics, piezoelectric, rectifier, Rectifiers, Substrates, Ultrasonic power transfer, optogenetic stimulation, ultrasonic power transfer",

author = "Kjeld Laursen and Milad Zamani and Yasser Rezaeiyan and Seyedsina Hosseini and Tanmay Mondal and Brian Corbett and Ouagazzal, {Abdel Mouttalib} and Marianne Amalric and Farshad Moradi",

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An Ultrasonically-Powered System for 1.06mm³ Implantable Optogenetics and Drug Delivery Dust. / Laursen, Kjeld ; Zamani, Milad ; Rezaeiyan, Yasser et al.
I: IEEE Transactions on Circuits and Systems II: Express Briefs, Bind 70, Nr. 10, 01.10.2023, s. 3937-3941.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - An Ultrasonically-Powered System for 1.06mm3 Implantable Optogenetics and Drug Delivery Dust

AU - Laursen, Kjeld

AU - Zamani, Milad

AU - Rezaeiyan, Yasser

AU - Hosseini, Seyedsina

AU - Mondal, Tanmay

AU - Corbett, Brian

AU - Ouagazzal, Abdel Mouttalib

AU - Amalric, Marianne

AU - Moradi, Farshad

PY - 2023/10/1

Y1 - 2023/10/1

N2 - This paper presents an ultrasonically powered micro-system for deep tissue optogenetic stimulation. The developed system is composed of a Base for Powering and Controlling (BPC) and an implantable Dust for optogenetics and drug delivery. The Dust consists of a piezoelectric crystal, a rectifier chip, and a micro-scale custom-designed light-emitting-diode (μLED) integrated, miniaturized, and envisioned to be used for freely moving animal studies. The proposed Dust operates in frequencies up to 5 MHz, power levels in the 0–10 mW range, achieves start-up within 1.8 μs at 2.9 MHz operating frequency at 14.4 mW/mm2 ultrasound power density, and 98.1% chip efficiency at 2 mW input power. With the BPC implemented and attached to (500 μm)3 PZT4 crystals, set to 60 V at 2.8 MHz operating frequency at 3 mm distance in demineralized water, the dust delivered up to 6 mW to its load (μLED for optogenetics), which translates to 0.11% total system efficiency.

AB - This paper presents an ultrasonically powered micro-system for deep tissue optogenetic stimulation. The developed system is composed of a Base for Powering and Controlling (BPC) and an implantable Dust for optogenetics and drug delivery. The Dust consists of a piezoelectric crystal, a rectifier chip, and a micro-scale custom-designed light-emitting-diode (μLED) integrated, miniaturized, and envisioned to be used for freely moving animal studies. The proposed Dust operates in frequencies up to 5 MHz, power levels in the 0–10 mW range, achieves start-up within 1.8 μs at 2.9 MHz operating frequency at 14.4 mW/mm2 ultrasound power density, and 98.1% chip efficiency at 2 mW input power. With the BPC implemented and attached to (500 μm)3 PZT4 crystals, set to 60 V at 2.8 MHz operating frequency at 3 mm distance in demineralized water, the dust delivered up to 6 mW to its load (μLED for optogenetics), which translates to 0.11% total system efficiency.

KW - Bridge circuits

KW - Crystals

KW - Dust

KW - Light emitting diodes

KW - Logic gates

KW - Optogenetic stimulation

KW - Optogenetics

KW - piezoelectric

KW - rectifier

KW - Rectifiers

KW - Substrates

KW - Ultrasonic power transfer

KW - optogenetic stimulation

KW - ultrasonic power transfer

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U2 - 10.1109/TCSII.2023.3289028

DO - 10.1109/TCSII.2023.3289028

M3 - Journal article

AN - SCOPUS:85163566874

SN - 1549-7747

VL - 70

SP - 3937

EP - 3941

JO - IEEE Transactions on Circuits and Systems II: Express Briefs

JF - IEEE Transactions on Circuits and Systems II: Express Briefs

IS - 10