TY - JOUR
T1 - An Ultrasonically-Powered System for 1.06mm3 Implantable Optogenetics and Drug Delivery Dust
AU - Laursen, Kjeld
AU - Zamani, Milad
AU - Rezaeiyan, Yasser
AU - Hosseini, Seyedsina
AU - Mondal, Tanmay
AU - Corbett, Brian
AU - Ouagazzal, Abdel Mouttalib
AU - Amalric, Marianne
AU - Moradi, Farshad
PY - 2023/10/1
Y1 - 2023/10/1
N2 - This paper presents an ultrasonically powered micro-system for deep tissue optogenetic stimulation. The developed system is composed of a Base for Powering and Controlling (BPC) and an implantable Dust for optogenetics and drug delivery. The Dust consists of a piezoelectric crystal, a rectifier chip, and a micro-scale custom-designed light-emitting-diode (μLED) integrated, miniaturized, and envisioned to be used for freely moving animal studies. The proposed Dust operates in frequencies up to 5 MHz, power levels in the 0–10 mW range, achieves start-up within 1.8 μs at 2.9 MHz operating frequency at 14.4 mW/mm2 ultrasound power density, and 98.1% chip efficiency at 2 mW input power. With the BPC implemented and attached to (500 μm)3 PZT4 crystals, set to 60 V at 2.8 MHz operating frequency at 3 mm distance in demineralized water, the dust delivered up to 6 mW to its load (μLED for optogenetics), which translates to 0.11% total system efficiency.
AB - This paper presents an ultrasonically powered micro-system for deep tissue optogenetic stimulation. The developed system is composed of a Base for Powering and Controlling (BPC) and an implantable Dust for optogenetics and drug delivery. The Dust consists of a piezoelectric crystal, a rectifier chip, and a micro-scale custom-designed light-emitting-diode (μLED) integrated, miniaturized, and envisioned to be used for freely moving animal studies. The proposed Dust operates in frequencies up to 5 MHz, power levels in the 0–10 mW range, achieves start-up within 1.8 μs at 2.9 MHz operating frequency at 14.4 mW/mm2 ultrasound power density, and 98.1% chip efficiency at 2 mW input power. With the BPC implemented and attached to (500 μm)3 PZT4 crystals, set to 60 V at 2.8 MHz operating frequency at 3 mm distance in demineralized water, the dust delivered up to 6 mW to its load (μLED for optogenetics), which translates to 0.11% total system efficiency.
KW - Bridge circuits
KW - Crystals
KW - Dust
KW - Light emitting diodes
KW - Logic gates
KW - Optogenetic stimulation
KW - Optogenetics
KW - piezoelectric
KW - rectifier
KW - Rectifiers
KW - Substrates
KW - Ultrasonic power transfer
KW - optogenetic stimulation
KW - ultrasonic power transfer
UR - http://www.scopus.com/inward/record.url?scp=85163566874&partnerID=8YFLogxK
U2 - 10.1109/TCSII.2023.3289028
DO - 10.1109/TCSII.2023.3289028
M3 - Journal article
AN - SCOPUS:85163566874
SN - 1549-7747
VL - 70
SP - 3937
EP - 3941
JO - IEEE Transactions on Circuits and Systems II: Express Briefs
JF - IEEE Transactions on Circuits and Systems II: Express Briefs
IS - 10
ER -