An Intracortical Implantable Brain-Computer Interface for Telemetric Real-Time Recording and Manipulation of Neuronal Circuits for Closed-Loop Intervention

TY - JOUR

T1 - An Intracortical Implantable Brain-Computer Interface for Telemetric Real-Time Recording and Manipulation of Neuronal Circuits for Closed-Loop Intervention

AU - Zaer, Hamed

AU - Deshmukh, Ashlesha

AU - Orlowski, Dariusz

AU - Fan, Wei

AU - Prouvot, Pierre-Hugues

AU - Glud, Andreas Nørgaard

AU - Jensen, Morten Bjørn

AU - Worm, Esben Schjødt

AU - Lukacova, Slávka

AU - Mikkelsen, Trine Werenberg

AU - Fitting, Lise Moberg

AU - Adler, John R

AU - Schneider, M Bret

AU - Jensen, Martin Snejbjerg

AU - Fu, Quanhai

AU - Go, Vinson

AU - Morizio, James

AU - Sørensen, Jens Christian Hedemann

AU - Stroh, Albrecht

N1 - Copyright © 2021 Zaer, Deshmukh, Orlowski, Fan, Prouvot, Glud, Jensen, Worm, Lukacova, Mikkelsen, Fitting, Adler, Schneider, Jensen, Fu, Go, Morizio, Sørensen and Stroh.

PY - 2021/2/3

Y1 - 2021/2/3

N2 - Recording and manipulating neuronal ensemble activity is a key requirement in advanced neuromodulatory and behavior studies. Devices capable of both recording and manipulating neuronal activity brain-computer interfaces (BCIs) should ideally operate un-tethered and allow chronic longitudinal manipulations in the freely moving animal. In this study, we designed a new intracortical BCI feasible of telemetric recording and stimulating local gray and white matter of visual neural circuit after irradiation exposure. To increase the translational reliance, we put forward a Göttingen minipig model. The animal was stereotactically irradiated at the level of the visual cortex upon defining the target by a fused cerebral MRI and CT scan. A fully implantable neural telemetry system consisting of a 64 channel intracortical multielectrode array, a telemetry capsule, and an inductive rechargeable battery was then implanted into the visual cortex to record and manipulate local field potentials, and multi-unit activity. We achieved a 3-month stability of the functionality of the un-tethered BCI in terms of telemetric radio-communication, inductive battery charging, and device biocompatibility for 3 months. Finally, we could reliably record the local signature of sub- and suprathreshold neuronal activity in the visual cortex with high bandwidth without complications. The ability to wireless induction charging combined with the entirely implantable design, the rather high recording bandwidth, and the ability to record and stimulate simultaneously put forward a wireless BCI capable of long-term un-tethered real-time communication for causal preclinical circuit-based closed-loop interventions.

AB - Recording and manipulating neuronal ensemble activity is a key requirement in advanced neuromodulatory and behavior studies. Devices capable of both recording and manipulating neuronal activity brain-computer interfaces (BCIs) should ideally operate un-tethered and allow chronic longitudinal manipulations in the freely moving animal. In this study, we designed a new intracortical BCI feasible of telemetric recording and stimulating local gray and white matter of visual neural circuit after irradiation exposure. To increase the translational reliance, we put forward a Göttingen minipig model. The animal was stereotactically irradiated at the level of the visual cortex upon defining the target by a fused cerebral MRI and CT scan. A fully implantable neural telemetry system consisting of a 64 channel intracortical multielectrode array, a telemetry capsule, and an inductive rechargeable battery was then implanted into the visual cortex to record and manipulate local field potentials, and multi-unit activity. We achieved a 3-month stability of the functionality of the un-tethered BCI in terms of telemetric radio-communication, inductive battery charging, and device biocompatibility for 3 months. Finally, we could reliably record the local signature of sub- and suprathreshold neuronal activity in the visual cortex with high bandwidth without complications. The ability to wireless induction charging combined with the entirely implantable design, the rather high recording bandwidth, and the ability to record and stimulate simultaneously put forward a wireless BCI capable of long-term un-tethered real-time communication for causal preclinical circuit-based closed-loop interventions.

KW - EEG

KW - Göttingen minipig

KW - animal model

KW - brain-machine (computer) interface

KW - closed-loop

KW - electrophysiology

KW - neuromodulation

KW - stereotactic radiosurgery

UR - http://www.scopus.com/inward/record.url?scp=85100939885&partnerID=8YFLogxK

U2 - 10.3389/fnhum.2021.618626

DO - 10.3389/fnhum.2021.618626

M3 - Journal article

C2 - 33613212

SN - 1662-5161

VL - 15

JO - Frontiers in Human Neuroscience

JF - Frontiers in Human Neuroscience

M1 - 618626

ER -