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An insight into normal and pathological pregnancies using large-scale microarrays: lessons from microarrays

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

DOI

  • Gérard Chaouat
    • ,
  • Nathalie Rodde
    • ,
  • Marie Petitbarat
    • ,
  • Roberta Bulla
    • ,
  • Mona Rahmati
    • ,
  • Sylvie Dubanchet
    • ,
  • Sandrine Zourbas
    • ,
  • Isabelle Bataillon
    • ,
  • Nathalie Coqué
    • ,
  • Benoit Hennuy
    • ,
  • Jacques Martal
    • ,
  • Carine Munaut
    • ,
  • Julie Aubert
    • ,
  • Valérie Sérazin
    • ,
  • Thiel Steffen
    • ,
  • Jens Christian Jensenius
  • Jean Michel Foidart
    • ,
  • Olivier Sandra
    • ,
  • Francesco Tedesco
    • ,
  • Nathalie Lédée
In the introduction, we briefly recall old but classic evidence that there is no tolerance to paternal alloantigens in a first pregnancy. Therefore, we performed small- and large-scale microarrays in CBA × DBA/2 and CBA × BALB/c combinations, recently described as a murine model for preeclampsia. Our results are in line with other data suggesting a very early deregulation of local immune vascular events rather than a break of immune tolerance. Other data presented at the Tioman 2010 Preeclampsia Workshop supporting this hypothesis are briefly summarised, as well as indications and caveats from a recent human microarray on implantation failure and recurrent pregnancy loss.
OriginalsprogEngelsk
TidsskriftJournal of Reproductive Immunology
Vol/bind89
Nummer2
Sider (fra-til)163-72
Antal sider10
ISSN0165-0378
DOI
StatusUdgivet - 2011

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